ID   NDUF4_DROME             Reviewed;         203 AA.
AC   Q9VH39;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein NDUFAF4 homolog;
GN   ORFNames=CG11722;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Testis;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the NDUFAF4 family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF54481.1; -; Genomic_DNA.
DR   EMBL; AY070793; AAL48415.1; -; mRNA.
DR   RefSeq; NP_649970.1; NM_141713.4.
DR   AlphaFoldDB; Q9VH39; -.
DR   BioGRID; 66382; 5.
DR   DIP; DIP-17212N; -.
DR   IntAct; Q9VH39; 4.
DR   STRING; 7227.FBpp0081683; -.
DR   PaxDb; Q9VH39; -.
DR   PRIDE; Q9VH39; -.
DR   DNASU; 41227; -.
DR   EnsemblMetazoa; FBtr0082205; FBpp0081683; FBgn0037777.
DR   GeneID; 41227; -.
DR   KEGG; dme:Dmel_CG11722; -.
DR   UCSC; CG11722-RA; d. melanogaster.
DR   FlyBase; FBgn0037777; CG11722.
DR   VEuPathDB; VectorBase:FBgn0037777; -.
DR   eggNOG; KOG4481; Eukaryota.
DR   GeneTree; ENSGT00390000001627; -.
DR   HOGENOM; CLU_054693_1_0_1; -.
DR   InParanoid; Q9VH39; -.
DR   OMA; IPDQKYK; -.
DR   OrthoDB; 1395543at2759; -.
DR   PhylomeDB; Q9VH39; -.
DR   Reactome; R-DME-6799198; Complex I biogenesis.
DR   BioGRID-ORCS; 41227; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 41227; -.
DR   PRO; PR:Q9VH39; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0037777; Expressed in testis and 28 other tissues.
DR   Genevisible; Q9VH39; DM.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR   InterPro; IPR009622; NDUFAF4.
DR   PANTHER; PTHR13338; PTHR13338; 1.
DR   Pfam; PF06784; UPF0240; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..203
FT                   /note="Protein NDUFAF4 homolog"
FT                   /id="PRO_0000220990"
SQ   SEQUENCE   203 AA;  23705 MW;  325F385D98DC5F99 CRC64;
     MGQVVSMVAR RANRFNVENR AHRVLEREKP TPAPKFDSNL RDMERTLELD PKFVDKLNMK
     DSSLDGRLKD VYVTSQDRFI KRVQERQAAE AAADNVEQRP LPLERKTPDD FEYGYLEPNR
     ISPGHCTLRQ ALKFINDHQL DPESWPAKKI ANEYKLKEPL VENILHYFKT FNMYIPDQKY
     KDTMLTQATQ PLLRVKSSSE GNP