ID   NDUF4_PONAB             Reviewed;         175 AA.
AC   Q5R4R9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4;
DE   AltName: Full=Hormone-regulated proliferation-associated protein of 20 kDa homolog;
DE   AltName: Full=Protein HRPAP20;
GN   Name=NDUFAF4; Synonyms=HRPAP20;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in cell proliferation and survival of
CC       hormone-dependent tumor cells. Involved in the assembly of
CC       mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds calmodulin. Interacts with NDUFAF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q9P032}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q9P032}.
CC   -!- PTM: Phosphorylated on serine. Prolactin stimulate serine
CC       phosphorylation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF4 family. {ECO:0000305}.
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DR   EMBL; CR861175; CAH93247.1; -; mRNA.
DR   RefSeq; NP_001126910.1; NM_001133438.1.
DR   AlphaFoldDB; Q5R4R9; -.
DR   SMR; Q5R4R9; -.
DR   STRING; 9601.ENSPPYP00000018869; -.
DR   GeneID; 100173927; -.
DR   KEGG; pon:100173927; -.
DR   CTD; 29078; -.
DR   eggNOG; KOG4481; Eukaryota.
DR   InParanoid; Q5R4R9; -.
DR   OrthoDB; 1395543at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR   InterPro; IPR009622; NDUFAF4.
DR   PANTHER; PTHR13338; PTHR13338; 1.
DR   Pfam; PF06784; UPF0240; 1.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Lipoprotein; Membrane; Mitochondrion; Myristate;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
FT   CHAIN           2..175
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   assembly factor 4"
FT                   /id="PRO_0000284126"
FT   MOD_RES         35
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
SQ   SEQUENCE   175 AA;  20054 MW;  261D7F0EE1EA779A CRC64;
     MGALVIRGIR NFNLENRAER EISKMKPSVA PRHPSTNSLL REQISLYPEV KGEIARKDNK
     LLSLLKDVYV DSRDPVPSLQ VQAAETCQEP KEFRLPKDHH LDMINTKSIP KGKISITEAL
     SLLNNHKLFP ETWTAEKIAQ EYQLEQKDVN SLLKYFATFE VEIFPPEDTK AIQSK