ID   NDUF6_BOVIN             Reviewed;         333 AA.
AC   A7YVD7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=NADH dehydrogenase (ubiquinone) complex I, assembly factor 6;
DE   Flags: Precursor;
GN   Name=NDUFAF6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC       oxidoreductase complex (complex I) at early stages. May play a role in
CC       the biogenesis of complex I subunit MT-ND1.
CC       {ECO:0000250|UniProtKB:Q330K2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane. Note=Peripherally
CC       localized on the matrix face of the mitochondrial inner membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF6 family. {ECO:0000305}.
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DR   EMBL; BC123431; AAI23432.1; -; mRNA.
DR   RefSeq; NP_001098859.1; NM_001105389.1.
DR   AlphaFoldDB; A7YVD7; -.
DR   SMR; A7YVD7; -.
DR   STRING; 9913.ENSBTAP00000009959; -.
DR   PaxDb; A7YVD7; -.
DR   PRIDE; A7YVD7; -.
DR   Ensembl; ENSBTAT00000009959; ENSBTAP00000009959; ENSBTAG00000007570.
DR   GeneID; 523017; -.
DR   KEGG; bta:523017; -.
DR   CTD; 137682; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007570; -.
DR   VGNC; VGNC:31958; NDUFAF6.
DR   eggNOG; KOG4411; Eukaryota.
DR   GeneTree; ENSGT00510000048688; -.
DR   HOGENOM; CLU_037269_6_0_1; -.
DR   InParanoid; A7YVD7; -.
DR   OMA; RKFWLAW; -.
DR   OrthoDB; 616989at2759; -.
DR   TreeFam; TF300084; -.
DR   Reactome; R-BTA-6799198; Complex I biogenesis.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000007570; Expressed in longissimus thoracis muscle and 106 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR002060; Squ/phyt_synthse.
DR   Pfam; PF00494; SQS_PSY; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..44
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           45..333
FT                   /note="NADH dehydrogenase (ubiquinone) complex I, assembly
FT                   factor 6"
FT                   /id="PRO_0000327442"
SQ   SEQUENCE   333 AA;  38103 MW;  C22FF466336C6C86 CRC64;
     MAASTLGSAW GPLRLGVPGL CRRRPPRGLW ARARRLSEPV ASGRSVAAGS GLGASGTDRY
     CLELLRKRDY EGYLCSLLLP AESRSSAFAL RAFNVELAQI KDSVSEKTIG LMRMQFWKKT
     VDDIYSDNPP HQPVAIELWK AVRRHNLTKR WLMKIIDERE KNLDDKAYRN IQELENYAEN
     TQSSLLYLTL EILGIKDLHA DHAASHIGKA QGIVTCLRAT PYHGSRRRVF LPMDICMLHG
     VSQEDFLRKS QDRNVRDVVY DVASQAHLHL KHARSFHRSI PVKAFPAFLQ TVALEDYLKK
     IQQVDFDLFH PSLQRKNTLL PLSLYIQSWR KRY