ID   NDUF6_DICDI             Reviewed;         356 AA.
AC   Q54E48;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0291852;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC       oxidoreductase complex (complex I) at early stages. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF6 family. {ECO:0000305}.
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DR   EMBL; AAFI02000185; EAL61547.1; -; Genomic_DNA.
DR   RefSeq; XP_629939.1; XM_629937.1.
DR   AlphaFoldDB; Q54E48; -.
DR   SMR; Q54E48; -.
DR   STRING; 44689.DDB0267055; -.
DR   PaxDb; Q54E48; -.
DR   EnsemblProtists; EAL61547; EAL61547; DDB_G0291852.
DR   GeneID; 8628345; -.
DR   KEGG; ddi:DDB_G0291852; -.
DR   dictyBase; DDB_G0291852; -.
DR   eggNOG; KOG4411; Eukaryota.
DR   HOGENOM; CLU_037269_6_2_1; -.
DR   InParanoid; Q54E48; -.
DR   OMA; RKFWLAW; -.
DR   PhylomeDB; Q54E48; -.
DR   PRO; PR:Q54E48; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR002060; Squ/phyt_synthse.
DR   Pfam; PF00494; SQS_PSY; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..41
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..356
FT                   /note="NADH dehydrogenase (ubiquinone) complex I, assembly
FT                   factor 6 homolog"
FT                   /id="PRO_0000327443"
SQ   SEQUENCE   356 AA;  40811 MW;  FA3B105DA7B85C2A CRC64;
     MIRNSGRILF NSLKNSNVKL INRNVIINSN IRLFSTSTNN TIKESVEKKA ETISNKDNIA
     SPSSKSIDVS DLAGNADYNF VFERIKTCDK ENYINSLLIS DPIARRVAYA IRAFNIETVA
     NDHSPKSEKI SRLRLSFWKD AINNIYNGKV YDQPLTRVLA QVIKEKKLTK TWFIKILNRR
     EKDNQQVQIK DMEELEQYAD DIHSSLMLLT LEGLGVKGNH DVEHCASHLG KAIGIMVLIR
     GTVYHLASRK TYIPVSLTTK YGINVESLYR GDPQIEKLQN AIYEMASCAK LHLDKAKQFR
     GKIPHPATEA FLSVSVVEDF LERLRKADFN IFEFPNTQQH PLLLIKLYKN KFFKQF