ID   NDUF6_MOUSE             Reviewed;         333 AA.
AC   A2AIL4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=NADH dehydrogenase (ubiquinone) complex I, assembly factor 6;
DE   Flags: Precursor;
GN   Name=Ndufaf6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=18614015; DOI=10.1016/j.cell.2008.06.016;
RA   Pagliarini D.J., Calvo S.E., Chang B., Sheth S.A., Vafai S.B., Ong S.E.,
RA   Walford G.A., Sugiana C., Boneh A., Chen W.K., Hill D.E., Vidal M.,
RA   Evans J.G., Thorburn D.R., Carr S.A., Mootha V.K.;
RT   "A mitochondrial protein compendium elucidates complex I disease biology.";
RL   Cell 134:112-123(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC       oxidoreductase complex (complex I) at early stages. May play a role in
CC       the biogenesis of complex I subunit MT-ND1.
CC       {ECO:0000250|UniProtKB:Q330K2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000269|PubMed:18614015}. Note=Peripherally localized on the
CC       matrix face of the mitochondrial inner membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF6 family. {ECO:0000305}.
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DR   EMBL; AL732497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38691.1; -.
DR   RefSeq; NP_001078962.1; NM_001085493.2.
DR   AlphaFoldDB; A2AIL4; -.
DR   SMR; A2AIL4; -.
DR   BioGRID; 218420; 4.
DR   STRING; 10090.ENSMUSP00000062039; -.
DR   iPTMnet; A2AIL4; -.
DR   PhosphoSitePlus; A2AIL4; -.
DR   EPD; A2AIL4; -.
DR   MaxQB; A2AIL4; -.
DR   PaxDb; A2AIL4; -.
DR   PeptideAtlas; A2AIL4; -.
DR   PRIDE; A2AIL4; -.
DR   ProteomicsDB; 252944; -.
DR   Antibodypedia; 63909; 17 antibodies from 7 providers.
DR   DNASU; 76947; -.
DR   Ensembl; ENSMUST00000058183; ENSMUSP00000062039; ENSMUSG00000050323.
DR   GeneID; 76947; -.
DR   KEGG; mmu:76947; -.
DR   UCSC; uc008ryx.3; mouse.
DR   CTD; 137682; -.
DR   MGI; MGI:1924197; Ndufaf6.
DR   VEuPathDB; HostDB:ENSMUSG00000050323; -.
DR   eggNOG; KOG4411; Eukaryota.
DR   GeneTree; ENSGT00510000048688; -.
DR   HOGENOM; CLU_037269_6_0_1; -.
DR   InParanoid; A2AIL4; -.
DR   OMA; RKFWLAW; -.
DR   OrthoDB; 616989at2759; -.
DR   PhylomeDB; A2AIL4; -.
DR   TreeFam; TF300084; -.
DR   Reactome; R-MMU-6799198; Complex I biogenesis.
DR   BioGRID-ORCS; 76947; 14 hits in 73 CRISPR screens.
DR   PRO; PR:A2AIL4; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2AIL4; protein.
DR   Bgee; ENSMUSG00000050323; Expressed in extra-ocular muscle and 181 other tissues.
DR   Genevisible; A2AIL4; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:MGI.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR002060; Squ/phyt_synthse.
DR   Pfam; PF00494; SQS_PSY; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..44
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           45..333
FT                   /note="NADH dehydrogenase (ubiquinone) complex I, assembly
FT                   factor 6"
FT                   /id="PRO_0000291773"
SQ   SEQUENCE   333 AA;  38362 MW;  2E457A8D07702BF8 CRC64;
     MATSMLGSVR GPRPFGLANL FHRQPPRDAW ERVRRLPGPS AVRRSVAAAS GPGIPGSHLY
     CLELLRKRDY ESYLCSLLFP AECQRSASAL RAFNVELAQV KDSVSEKTIG LMRMQFWKKA
     VEDMYCDNPP HQPVAIELWK AVKKHNLTKR WLMRIIDERE KNLDDKAYRS MQELENYAEN
     TQGSLLYLTL EVLGVKDLHA DHAASHIGKA QGIVTCLRAT PYHSSRRQVF LPMDVCVQHG
     VSQEDFLRRN QDKNVRDVVY DIASQAHLHL KHARSFHRSV PAEAFPAFLQ TVSLEDYLKK
     IQRVDFDIFH PSLQQKNMLL PLSLYIQSWR KRY