ID   NDUF6_RAT               Reviewed;         333 AA.
AC   D3ZN43;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=NADH dehydrogenase (ubiquinone) complex I, assembly factor 6;
DE   Flags: Precursor;
GN   Name=Ndufaf6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC       oxidoreductase complex (complex I) at early stages. May play a role in
CC       the biogenesis of complex I subunit MT-ND1.
CC       {ECO:0000250|UniProtKB:Q330K2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC       Note=Peripherally localized on the matrix face of the mitochondrial
CC       inner membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF6 family. {ECO:0000305}.
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DR   EMBL; AABR03042038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03046646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473984; EDM11670.1; -; Genomic_DNA.
DR   RefSeq; NP_001263370.1; NM_001276441.1.
DR   AlphaFoldDB; D3ZN43; -.
DR   SMR; D3ZN43; -.
DR   STRING; 10116.ENSRNOP00000058286; -.
DR   PaxDb; D3ZN43; -.
DR   PeptideAtlas; D3ZN43; -.
DR   PRIDE; D3ZN43; -.
DR   Ensembl; ENSRNOT00000061569; ENSRNOP00000058286; ENSRNOG00000040040.
DR   GeneID; 297821; -.
DR   KEGG; rno:297821; -.
DR   UCSC; RGD:1309085; rat.
DR   CTD; 137682; -.
DR   RGD; 1309085; Ndufaf6.
DR   eggNOG; KOG4411; Eukaryota.
DR   GeneTree; ENSGT00510000048688; -.
DR   HOGENOM; CLU_037269_6_0_1; -.
DR   InParanoid; D3ZN43; -.
DR   OrthoDB; 616989at2759; -.
DR   PhylomeDB; D3ZN43; -.
DR   TreeFam; TF300084; -.
DR   Reactome; R-RNO-6799198; Complex I biogenesis.
DR   PRO; PR:D3ZN43; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Proteomes; UP000234681; Chromosome 5.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR002060; Squ/phyt_synthse.
DR   Pfam; PF00494; SQS_PSY; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..44
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           45..333
FT                   /note="NADH dehydrogenase (ubiquinone) complex I, assembly
FT                   factor 6"
FT                   /id="PRO_0000418069"
SQ   SEQUENCE   333 AA;  38515 MW;  D4413DDC2CEF6BCF CRC64;
     MATSMLGSVP GPRPFGLAGL FRRRPPRDPW ERVRRLPRLS AVRRSVAAAS GPGIPDSHLY
     CLELLRKRDY ESYLCSLLFP AECQRSASAL RAFNVELAQV KDSVSEKTIG LMRMQFWRKA
     VEDMFCDNPP HQPVAMELWK AVKRHNLTKR WLLRIIDERE KNLDDKAYRS IRELETYAEN
     TQSSLLYLTL EVLGVKDVHA DHAASHIGKA QGIVTCLRAT PYHSSRRQVF LPMDVCVQHG
     VSQEDFLRRN QDKNVRDVVY DIASQAHLHL KHARSFHSRV PAEAFPAFLQ TVSLEDYLKK
     IQRVDFDIFH PSLQQKNTLL PLSLYIQSWR KRY