NDUF7_DROME
ID NDUF7_DROME Reviewed; 437 AA.
AC Q9VGR2; Q6NLJ4; Q8MYZ3; Q95S80;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial {ECO:0000250|UniProtKB:Q7L592};
DE EC=2.1.1.320 {ECO:0000250|UniProtKB:Q7L592};
DE AltName: Full=NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog;
DE AltName: Full=Protein midA homolog;
GN ORFNames=CG17726;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Arginine methyltransferase involved in the assembly or
CC stability of mitochondrial NADH:ubiquinone oxidoreductase complex
CC (complex I). {ECO:0000250|UniProtKB:Q7L592}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48108, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:88221; EC=2.1.1.320;
CC Evidence={ECO:0000250|UniProtKB:Q7L592};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q7L592}.
CC -!- SIMILARITY: Belongs to the NDUFAF7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28469.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAM29473.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF54614.1; -; Genomic_DNA.
DR EMBL; AY060921; AAL28469.1; ALT_INIT; mRNA.
DR EMBL; AY113468; AAM29473.1; ALT_SEQ; mRNA.
DR EMBL; BT012337; AAS77462.1; -; mRNA.
DR RefSeq; NP_650054.2; NM_141797.4.
DR AlphaFoldDB; Q9VGR2; -.
DR SMR; Q9VGR2; -.
DR BioGRID; 66483; 2.
DR IntAct; Q9VGR2; 2.
DR STRING; 7227.FBpp0081828; -.
DR PaxDb; Q9VGR2; -.
DR PRIDE; Q9VGR2; -.
DR DNASU; 41349; -.
DR EnsemblMetazoa; FBtr0082352; FBpp0081828; FBgn0037880.
DR GeneID; 41349; -.
DR KEGG; dme:Dmel_CG17726; -.
DR UCSC; CG17726-RA; d. melanogaster.
DR FlyBase; FBgn0037880; CG17726.
DR VEuPathDB; VectorBase:FBgn0037880; -.
DR eggNOG; KOG2901; Eukaryota.
DR GeneTree; ENSGT00390000001588; -.
DR HOGENOM; CLU_024840_3_1_1; -.
DR InParanoid; Q9VGR2; -.
DR OMA; YYHPQRN; -.
DR OrthoDB; 491869at2759; -.
DR PhylomeDB; Q9VGR2; -.
DR Reactome; R-DME-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 41349; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 41349; -.
DR PRO; PR:Q9VGR2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037880; Expressed in secondary oocyte and 19 other tissues.
DR ExpressionAtlas; Q9VGR2; baseline and differential.
DR Genevisible; Q9VGR2; DM.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 3.40.50.12710; -; 1.
DR InterPro; IPR003788; NDUFAF7.
DR InterPro; IPR038375; NDUFAF7_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12049; PTHR12049; 1.
DR Pfam; PF02636; Methyltransf_28; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Mitochondrion; Reference proteome; Transferase.
FT CHAIN 1..437
FT /note="Protein arginine methyltransferase NDUFAF7 homolog,
FT mitochondrial"
FT /id="PRO_0000315679"
FT REGION 21..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 275
FT /note="L -> P (in Ref. 4; AAS77462)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="T -> P (in Ref. 4; AAS77462)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="K -> E (in Ref. 4; AAS77462)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="S -> R (in Ref. 4; AAS77462)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 49068 MW; 0CBBB79AB1638CEB CRC64;
MLREALRIGN RRWYSYKSVR RPNLGATGTP KMEPPKEQPE ASSKAESGHG SLAKQLRAKI
LSTGPIPVAE YMREVLTNPQ AGYYMNRDVF GREGDFITSP EISQIFGELV GIWLVSEWRK
MGSPSPFQLV ELGPGRGTLA RDVLKVLTKF KQDAEFSMHM VEVSPFLSKA QAQRFCYSHQ
TLPEDAQLPH YQEGTTASGT KAFWHRRLED VPQGFSLVLA HEFFDALPVH KLQLVDGKWQ
EVLIDVASSD GAQEASFRYV LSRSQTPVSS LYRPLPGETR SCLEHSLETE RQVGLLAERI
ERDGGIALIM DYGHFGEKTD TFRAFKQHKL HDPLVEPGSA DLTADVDFKL VRHIAETRGN
VHCCGPVEQG LFLQRMQGEA RLEQLLAHAL PENQEIIRSG YEMLTDPAQM GTRFKFLAMF
PGVLAAHLDK YPVVGFS
