NDUF7_YEAST
ID NDUF7_YEAST Reviewed; 402 AA.
AC P36052; D6VX37;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial {ECO:0000250|UniProtKB:Q7L592};
DE EC=2.1.1.320 {ECO:0000250|UniProtKB:Q7L592};
DE AltName: Full=NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog;
DE AltName: Full=Protein midA homolog;
GN OrderedLocusNames=YKL162C; ORFNames=YKL616;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091859; DOI=10.1002/yea.320100005;
RA Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci
RT of chromosome XI of Saccharomyces cerevisiae.";
RL Yeast 10:S35-S40(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Arginine methyltransferase involved in the assembly or
CC stability of mitochondrial NADH:ubiquinone oxidoreductase complex
CC (complex I). {ECO:0000250|UniProtKB:Q7L592}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48108, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:88221; EC=2.1.1.320;
CC Evidence={ECO:0000250|UniProtKB:Q7L592};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1100 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the NDUFAF7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z26877; CAA81492.1; -; Genomic_DNA.
DR EMBL; Z28162; CAA82004.1; -; Genomic_DNA.
DR EMBL; AY692700; AAT92719.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09003.1; -; Genomic_DNA.
DR PIR; S37789; S37789.
DR RefSeq; NP_012760.1; NM_001179728.1.
DR AlphaFoldDB; P36052; -.
DR BioGRID; 33976; 41.
DR STRING; 4932.YKL162C; -.
DR MaxQB; P36052; -.
DR PaxDb; P36052; -.
DR EnsemblFungi; YKL162C_mRNA; YKL162C; YKL162C.
DR GeneID; 853695; -.
DR KEGG; sce:YKL162C; -.
DR SGD; S000001645; YKL162C.
DR VEuPathDB; FungiDB:YKL162C; -.
DR eggNOG; ENOG502RR6Q; Eukaryota.
DR HOGENOM; CLU_056775_0_0_1; -.
DR InParanoid; P36052; -.
DR OMA; YPYYDLN; -.
DR BioCyc; YEAST:G3O-31930-MON; -.
DR PRO; PR:P36052; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36052; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IBA:GO_Central.
DR InterPro; IPR003788; NDUFAF7.
DR PANTHER; PTHR12049; PTHR12049; 1.
DR Pfam; PF02636; Methyltransf_28; 1.
PE 1: Evidence at protein level;
KW Methyltransferase; Mitochondrion; Reference proteome; Transferase.
FT CHAIN 1..402
FT /note="Protein arginine methyltransferase NDUFAF7 homolog,
FT mitochondrial"
FT /id="PRO_0000203142"
SQ SEQUENCE 402 AA; 46509 MW; 768C114D7BCA33B0 CRC64;
MMKRLHPLRI QVHLKSDYPL FTFEQLLSTN GIRRGQTARI SLKDYIEWQN FPNIMKRENF
FTQRKPVTTT AKEEPFSFDN ILDCEPQFSK CLAKWLLVNY KLNDYPYYDL NIVNIYTDLP
QAIQICKNLM SYLKSTLSDN MFQKIKYFMV PLYKCDKIPS KLLDGIPGSV SLVQDYPVSP
YFLQKKFHIE DPIQILMLND VIKYTTHDLV RYSSDDKGWQ QCFVDINKNG QKSKSFDSAI
DYSCELALEQ MFNDRSHVSP GKELYIPTKL IEILMTIKNN IPEHRLFIVD TPQRSSPTII
SLLKSLISPR PTGSSQIVQP YSDSIFSDKR SGRICFMTDF LQLQNIYNGI NSSSSSCEVE
DVADFVEKWI SPSERSTLSS QNGNRPQLED IKNSSLAVLH ST
