NDUF8_MOUSE
ID NDUF8_MOUSE Reviewed; 74 AA.
AC A2AMZ4; B2RWC2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 {ECO:0000250|UniProtKB:A1L188};
GN Name=Ndufaf8 {ECO:0000250|UniProtKB:A1L188};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC oxidoreductase complex (complex I, MT-ND1). Required to stabilize
CC NDUFAF5. {ECO:0000250|UniProtKB:A1L188}.
CC -!- SUBUNIT: Interacts with NDUFAF5. {ECO:0000250|UniProtKB:A1L188}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:A1L188}.
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DR EMBL; AL807824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC147711; AAI47712.1; -; mRNA.
DR EMBL; BC147720; AAI47721.1; -; mRNA.
DR CCDS; CCDS36388.1; -.
DR RefSeq; NP_001103712.1; NM_001110242.1.
DR AlphaFoldDB; A2AMZ4; -.
DR SMR; A2AMZ4; -.
DR PhosphoSitePlus; A2AMZ4; -.
DR MaxQB; A2AMZ4; -.
DR PaxDb; A2AMZ4; -.
DR PeptideAtlas; A2AMZ4; -.
DR PRIDE; A2AMZ4; -.
DR ProteomicsDB; 252871; -.
DR Ensembl; ENSMUST00000106223; ENSMUSP00000101830; ENSMUSG00000078572.
DR GeneID; 208501; -.
DR KEGG; mmu:208501; -.
DR UCSC; uc007mru.2; mouse.
DR CTD; 284184; -.
DR MGI; MGI:1913676; Ndufaf8.
DR VEuPathDB; HostDB:ENSMUSG00000078572; -.
DR eggNOG; ENOG502SBX9; Eukaryota.
DR GeneTree; ENSGT00520000061927; -.
DR HOGENOM; CLU_188562_0_0_1; -.
DR InParanoid; A2AMZ4; -.
DR OMA; KTCFTNA; -.
DR OrthoDB; 1633553at2759; -.
DR PhylomeDB; A2AMZ4; -.
DR BioGRID-ORCS; 208501; 20 hits in 74 CRISPR screens.
DR ChiTaRS; Ndufaf8; mouse.
DR PRO; PR:A2AMZ4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2AMZ4; protein.
DR Bgee; ENSMUSG00000078572; Expressed in interventricular septum and 220 other tissues.
DR ExpressionAtlas; A2AMZ4; baseline and differential.
DR Genevisible; A2AMZ4; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:MGI.
DR InterPro; IPR034595; NDUFAF8.
DR PANTHER; PTHR34561; PTHR34561; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..74
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT assembly factor 8"
FT /id="PRO_0000299481"
FT DOMAIN 22..69
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 25..35
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 51..61
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 25..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 35..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 74 AA; 7785 MW; C802666F70B4889C CRC64;
MSVNGAVWGR VRSRFRAFPE HLAACGAEAS AYGKCVQAST APGGRLSKDL CVREFEALRS
CFAAAAKKTM MGGS
