ID   NDUS2_NYCOV             Reviewed;         412 AA.
AC   Q5DUX5;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=nad7;
OS   Nyctotherus ovalis.
OG   Hydrogenosome.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Armophorea;
OC   Metopida; Metopidae; Nyctotherus.
OX   NCBI_TaxID=70075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15744302; DOI=10.1038/nature03343;
RA   Boxma B., de Graaf R.M., van der Staay G.W.M., van Alen T.A., Ricard G.,
RA   Gabaldon T., van Hoek A.H.A.M., Moon-van der Staay S.Y., Koopman W.J.H.,
RA   van Hellemond J.J., Tielens A.G.M., Friedrich T., Veenhuis M., Huynen M.A.,
RA   Hackstein J.H.P.;
RT   "An anaerobic mitochondrion that produces hydrogen.";
RL   Nature 434:74-79(2005).
CC   -!- FUNCTION: Transfer of electrons from NADH to the respiratory chain. The
CC       immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone. Component of the iron-sulfur (IP) fragment of the enzyme.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Hydrogenosome.
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AJ871267; CAI38863.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5DUX5; -.
DR   SMR; Q5DUX5; -.
DR   GO; GO:0042566; C:hydrogenosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   Gene3D; 1.10.645.10; -; 1.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR022885; NDH1_su_D/H.
DR   InterPro; IPR029014; NiFe-Hase_large.
DR   PANTHER; PTHR11993; PTHR11993; 1.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   SUPFAM; SSF56762; SSF56762; 1.
PE   3: Inferred from homology;
KW   Hydrogenosome; NAD; Oxidoreductase; Translocase; Ubiquinone.
FT   CHAIN           1..412
FT                   /note="NADH-ubiquinone oxidoreductase 49 kDa subunit"
FT                   /id="PRO_0000118595"
SQ   SEQUENCE   412 AA;  46974 MW;  2760DF6EB2DB6E89 CRC64;
     MMRSSSLQKN IMLLRVGSKD STRFRILILN FGPQHPASHG VLRLVIVIIG EVVTKLDPHI
     GFLHRGTERL VEEHSYMNAA VFMDRLDYTT VLTQTHAYCL AVEQALAKSR LCIRTQLLRT
     IFDELSRILN HLLSIATHAL DIGTMAMLFW AFEDRERIME LYEYISGARM HTALYYPNQT
     LDHILTNELL AKILIFSRNS EKTYTEIYIA LYNNRVWRLR LCGIGVVSTE ISTSTTISGP
     VARSTGLQLD MRSGENYQYG YYASLTLRIF LGISGDSFDR FIIRLRELFE STRLIYNSLI
     ELSAYINISV YNMCSYSNNP HLKIESLIEL FRYSLGEYLL NISLVSGFVE SGKGIFGIML
     AANNTNRPYR LYIRSPAYMH LQLLPKLGAG HHIADLATLL GSIDVVFGEV DR