NDUS3_DICDI
ID NDUS3_DICDI Reviewed; 209 AA.
AC P22237;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=NADH-ubiquinone oxidoreductase subunit 9;
DE EC=7.1.1.2;
GN Name=nad9; Synonyms=ndufs3, noxA; ORFNames=DDB_G0294032;
OS Dictyostelium discoideum (Slime mold).
OG Mitochondrion.
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2102381; DOI=10.1007/bf00017840;
RA Tanaka Y., Kuroe K., Angata K., Yanagisawa K.;
RT "ORF209 of Dictyostelium discoideum mitochondrial DNA has a homologue in
RT chloroplast DNA.";
RL Plant Mol. Biol. 15:659-660(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=10821186; DOI=10.1007/pl00008685;
RA Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT content and genome organization.";
RL Mol. Gen. Genet. 263:514-519(2000).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of about 45 different subunits.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
CC {ECO:0000305}.
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DR EMBL; X52680; CAA36903.1; -; Genomic_DNA.
DR EMBL; AB000109; BAA78066.1; -; Genomic_DNA.
DR PIR; S12247; S12247.
DR RefSeq; NP_050084.1; NC_000895.1.
DR AlphaFoldDB; P22237; -.
DR SMR; P22237; -.
DR GeneID; 2193912; -.
DR KEGG; ddi:DidioMp17; -.
DR dictyBase; DDB_G0294032; nad9.
DR InParanoid; P22237; -.
DR PhylomeDB; P22237; -.
DR Reactome; R-DDI-6799198; Complex I biogenesis.
DR PRO; PR:P22237; -.
DR Proteomes; UP000002195; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.460.80; -; 1.
DR HAMAP; MF_01357; NDH1_NuoC; 1.
DR InterPro; IPR010218; NADH_DH_suC.
DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR Pfam; PF00329; Complex1_30kDa; 1.
DR SUPFAM; SSF143243; SSF143243; 1.
DR PROSITE; PS00542; COMPLEX1_30K; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Oxidoreductase; Reference proteome; Respiratory chain; Translocase;
KW Transport; Ubiquinone.
FT CHAIN 1..209
FT /note="NADH-ubiquinone oxidoreductase subunit 9"
FT /id="PRO_0000118645"
SQ SEQUENCE 209 AA; 25033 MW; A22D482B71B38374 CRC64;
MKDYKNELKV KINLGEHLRL SIPGLVKKIM YKTHYLEIQV EKEKMLTVLK YLKEASKYQC
NMLLDIVCVD CLNIEEIKIG RFKLIYVLNS IYNNTRVHLS TYVENNGIIE TTSGLFESSV
WLEREIWDMF GIYFEKHPDL RRILTDYGFV GYPLKKDFPI TGYLEVYYDV NDKKIIYKPI
ELMQEYRNYN FGAVWGDYER KVYLENIIK
