ID   NDUS4_DICDI             Reviewed;         190 AA.
AC   Q8T1V6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;
DE   Flags: Precursor;
GN   Name=ndufs4; ORFNames=DDB_G0295657;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This is a
CC       component of the iron-sulfur (IP) fragment of the enzyme (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS4 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000020; EDR41095.1; -; Genomic_DNA.
DR   RefSeq; XP_001732977.1; XM_001732925.1.
DR   AlphaFoldDB; Q8T1V6; -.
DR   SMR; Q8T1V6; -.
DR   STRING; 44689.DDB0237483; -.
DR   PaxDb; Q8T1V6; -.
DR   PRIDE; Q8T1V6; -.
DR   EnsemblProtists; EDR41095; EDR41095; DDB_G0295657.
DR   GeneID; 8621140; -.
DR   KEGG; ddi:DDB_G0295657; -.
DR   dictyBase; DDB_G0295657; ndufs4.
DR   eggNOG; KOG3389; Eukaryota.
DR   HOGENOM; CLU_077196_3_0_1; -.
DR   InParanoid; Q8T1V6; -.
DR   OMA; KWNDRLM; -.
DR   PhylomeDB; Q8T1V6; -.
DR   PRO; PR:Q8T1V6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:dictyBase.
DR   GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:dictyBase.
DR   Gene3D; 3.30.160.190; -; 1.
DR   InterPro; IPR006885; NADH_UbQ_FeS_4_mit.
DR   InterPro; IPR038532; NDUFS4-like_sf.
DR   PANTHER; PTHR12219; PTHR12219; 1.
DR   Pfam; PF04800; ETC_C1_NDUFA4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transit peptide; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           ?..190
FT                   /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT                   4, mitochondrial"
FT                   /id="PRO_0000330639"
SQ   SEQUENCE   190 AA;  21749 MW;  E63E3B11BFE5FE83 CRC64;
     MLKKFLISSI VKPTFQSRII ASTTLNGGAG RATFCSVNSI NPNPTASQIK VDQEDLEVGE
     HLVIDDPNQQ HIKSFLNGVE FNGKSVNIYR PSRNTMQTGT LRTKKWVIEL PFNPKWNDRL
     MGWWASKDTL NQLNLRFNSE TDAVAYCKEI GLNYNIVEED VTLRKKKKYG HRFRYRGDLV
     GEKEREVGIN