ID   NDUS4_GORGO             Reviewed;         175 AA.
AC   Q0MQH0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;
DE   AltName: Full=Complex I-18 kDa;
DE            Short=CI-18 kDa;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 18 kDa subunit;
DE   Flags: Precursor;
GN   Name=NDUFS4;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O43181}.
CC   -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC       is a component of the iron-sulfur (IP) fragment of the enzyme.
CC       Interacts with BCAP31 and TOMM40; the interaction mediates its
CC       translocation to the mitochondria; the interaction with BCAP31 is
CC       direct. {ECO:0000250|UniProtKB:O43181}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O43181}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O43181}; Matrix side
CC       {ECO:0000250|UniProtKB:O43181}. Note=The interaction with BCAP31
CC       mediates mitochondria localization. {ECO:0000250|UniProtKB:O43181}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS4 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885664; ABH12173.1; -; mRNA.
DR   RefSeq; NP_001266651.1; NM_001279722.1.
DR   AlphaFoldDB; Q0MQH0; -.
DR   SMR; Q0MQH0; -.
DR   STRING; 9593.ENSGGOP00000001226; -.
DR   Ensembl; ENSGGOT00000001250; ENSGGOP00000001226; ENSGGOG00000001243.
DR   GeneID; 101125075; -.
DR   KEGG; ggo:101125075; -.
DR   CTD; 4724; -.
DR   eggNOG; KOG3389; Eukaryota.
DR   GeneTree; ENSGT00390000013835; -.
DR   HOGENOM; CLU_077196_3_0_1; -.
DR   InParanoid; Q0MQH0; -.
DR   OMA; GTIMKFD; -.
DR   OrthoDB; 1507807at2759; -.
DR   Proteomes; UP000001519; Chromosome 17.
DR   Bgee; ENSGGOG00000001243; Expressed in heart and 6 other tissues.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0045333; P:cellular respiration; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0051591; P:response to cAMP; ISS:UniProtKB.
DR   Gene3D; 3.30.160.190; -; 1.
DR   InterPro; IPR006885; NADH_UbQ_FeS_4_mit.
DR   InterPro; IPR038532; NDUFS4-like_sf.
DR   PANTHER; PTHR12219; PTHR12219; 1.
DR   Pfam; PF04800; ETC_C1_NDUFA4; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transit peptide; Transport.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           43..175
FT                   /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT                   4, mitochondrial"
FT                   /id="PRO_0000251862"
FT   REGION          151..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   175 AA;  20108 MW;  DE5B51DBDD76231E CRC64;
     MAAVSMSVVL RQTLWRRRAV AVAALSVSRV PTRSLRTSTW RLAQDQTQDT QLITVDEKLD
     ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME FDTRERWENP LMGWASTADP
     LSNMVLTFST KEDAVSFAEK NGWSYDIEER KVPKPKSKSY GANFSWNKRT RVSTK