NDUS4_RAT
ID NDUS4_RAT Reviewed; 175 AA.
AC Q5XIF3; A1L111;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;
DE AltName: Full=Complex I-18 kDa;
DE Short=CI-18 kDa;
DE AltName: Full=NADH-ubiquinone oxidoreductase 18 kDa subunit;
DE Flags: Precursor;
GN Name=Ndufs4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 49-58, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (JUL-2007) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43181}.
CC -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC is a component of the iron-sulfur (IP) fragment of the enzyme.
CC Interacts with BCAP31 and TOMM40; the interaction mediates its
CC translocation to the mitochondria; the interaction with BCAP31 is
CC direct. {ECO:0000250|UniProtKB:O43181}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43181}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O43181}; Matrix side
CC {ECO:0000250|UniProtKB:O43181}. Note=The interaction with BCAP31
CC mediates mitochondria localization. {ECO:0000250|UniProtKB:O43181}.
CC -!- SIMILARITY: Belongs to the complex I NDUFS4 subunit family.
CC {ECO:0000305}.
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DR EMBL; BC083729; AAH83729.1; -; mRNA.
DR EMBL; BC127458; AAI27459.1; -; mRNA.
DR RefSeq; NP_001020317.1; NM_001025146.1.
DR AlphaFoldDB; Q5XIF3; -.
DR SMR; Q5XIF3; -.
DR BioGRID; 270838; 2.
DR STRING; 10116.ENSRNOP00000015217; -.
DR iPTMnet; Q5XIF3; -.
DR PhosphoSitePlus; Q5XIF3; -.
DR SwissPalm; Q5XIF3; -.
DR jPOST; Q5XIF3; -.
DR PaxDb; Q5XIF3; -.
DR PRIDE; Q5XIF3; -.
DR Ensembl; ENSRNOT00000015217; ENSRNOP00000015217; ENSRNOG00000011383.
DR GeneID; 499529; -.
DR KEGG; rno:499529; -.
DR CTD; 4724; -.
DR RGD; 1594380; Ndufs4.
DR eggNOG; KOG3389; Eukaryota.
DR GeneTree; ENSGT00390000013835; -.
DR HOGENOM; CLU_077196_3_0_1; -.
DR InParanoid; Q5XIF3; -.
DR OMA; GTIMKFD; -.
DR OrthoDB; 1507807at2759; -.
DR PhylomeDB; Q5XIF3; -.
DR TreeFam; TF105619; -.
DR Reactome; R-RNO-611105; Respiratory electron transport.
DR Reactome; R-RNO-6799198; Complex I biogenesis.
DR PRO; PR:Q5XIF3; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000011383; Expressed in heart and 20 other tissues.
DR Genevisible; Q5XIF3; RN.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISO:RGD.
DR GO; GO:0030534; P:adult behavior; ISO:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0045333; P:cellular respiration; ISO:RGD.
DR GO; GO:0071453; P:cellular response to oxygen levels; ISO:RGD.
DR GO; GO:0050890; P:cognition; ISO:RGD.
DR GO; GO:0042417; P:dopamine metabolic process; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0045087; P:innate immune response; ISO:RGD.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:RGD.
DR GO; GO:0070997; P:neuron death; ISO:RGD.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:RGD.
DR GO; GO:0036343; P:psychomotor behavior; ISO:RGD.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISO:RGD.
DR GO; GO:0001932; P:regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0022904; P:respiratory electron transport chain; ISO:RGD.
DR GO; GO:0003016; P:respiratory system process; ISO:RGD.
DR GO; GO:0051591; P:response to cAMP; ISO:RGD.
DR GO; GO:0014876; P:response to injury involved in regulation of muscle adaptation; ISO:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR Gene3D; 3.30.160.190; -; 1.
DR InterPro; IPR006885; NADH_UbQ_FeS_4_mit.
DR InterPro; IPR038532; NDUFS4-like_sf.
DR PANTHER; PTHR12219; PTHR12219; 1.
DR Pfam; PF04800; ETC_C1_NDUFA4; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transit peptide; Transport.
FT TRANSIT 1..42
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 43..175
FT /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT 4, mitochondrial"
FT /id="PRO_0000250709"
FT REGION 152..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43181"
SQ SEQUENCE 175 AA; 19741 MW; 726A1E60A4C8C205 CRC64;
MAAVSMSVSL RQALLRQRAV ATAAVSVCRV PSRLLNTSTW KLADGQTRDT QLITVDEKLD
VTPLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME FDTRERWENP LMGWASTADP
LSNMVLTFSA KEDAVAFAEK HGWSYDVEGR KVPKPKSKSY GANFSWNKRT RVSTK
