NDUS5_PONAB
ID NDUS5_PONAB Reviewed; 106 AA.
AC P0CB87; Q5R7L6;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;
DE AltName: Full=Complex I-15 kDa;
DE Short=CI-15 kDa;
DE AltName: Full=NADH-ubiquinone oxidoreductase 15 kDa subunit;
GN Name=NDUFS5;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43920}.
CC -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC is a component of the iron-sulfur (IP) fragment of the enzyme.
CC {ECO:0000250|UniProtKB:O43920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43920}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O43920}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:O43920}.
CC -!- DOMAIN: Contains two C-X9-C motifs that are predicted to form a helix-
CC coil-helix structure, permitting the formation of intramolecular
CC disulfide bonds. {ECO:0000250|UniProtKB:O43920}.
CC -!- SIMILARITY: Belongs to the complex I NDUFS5 subunit family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR860099; CAH92244.1; -; mRNA.
DR RefSeq; NP_001126312.1; NM_001132840.1.
DR RefSeq; XP_009250512.1; XM_009252237.1.
DR RefSeq; XP_009250514.1; XM_009252239.1.
DR AlphaFoldDB; P0CB87; -.
DR SMR; P0CB87; -.
DR STRING; 9601.ENSPPYP00000001746; -.
DR Ensembl; ENSPPYT00000001803; ENSPPYP00000001746; ENSPPYG00000001511.
DR GeneID; 100173291; -.
DR KEGG; pon:100173291; -.
DR CTD; 4725; -.
DR eggNOG; KOG4110; Eukaryota.
DR GeneTree; ENSGT00940000158787; -.
DR HOGENOM; CLU_176387_0_0_1; -.
DR InParanoid; P0CB87; -.
DR OrthoDB; 1549192at2759; -.
DR TreeFam; TF332111; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019342; NADH_UbQ_OxRdtase_FeS-su5.
DR PANTHER; PTHR15224; PTHR15224; 1.
DR Pfam; PF10200; Ndufs5; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT CHAIN 1..106
FT /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT 5"
FT /id="PRO_0000251867"
FT DOMAIN 30..74
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 78..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 33..43
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 56..66
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 33..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 43..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 106 AA; 12594 MW; 26529409D2F1ADFA CRC64;
MPFLDIQKRF GLNIDRWLTT QSAEQPYKMA SRCHAFEKEW IECAHGIGYT RAEKECKIEY
DDFIECLLRQ KTMRRTGTIR KQRDKLIKEG KYTPPPHHIG KGEPRP