NDUS6_BOVIN
ID NDUS6_BOVIN Reviewed; 124 AA.
AC P23934;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;
DE AltName: Full=Complex I-13kD-A;
DE Short=CI-13kD-A;
DE AltName: Full=NADH-ubiquinone oxidoreductase 13 kDa-A subunit;
DE Flags: Precursor;
GN Name=NDUFS6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP PROTEIN SEQUENCE OF 29-124.
RC TISSUE=Heart;
RX PubMed=1907966; DOI=10.1093/oxfordjournals.jbchem.a123416;
RA Masui R., Wakabayashi S., Matsubara H., Hatefi Y.;
RT "The amino acid sequences of two 13 kDa polypeptides and partial amino acid
RT sequence of 30 kDa polypeptide of complex I from bovine heart mitochondria:
RT possible location of iron-sulfur clusters.";
RL J. Biochem. 109:534-543(1991).
RN [3]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O75380}.
CC -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC is a component of the iron-sulfur (IP) fragment of the enzyme.
CC {ECO:0000269|PubMed:1518044, ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:18721790}; Peripheral membrane protein
CC {ECO:0000305}; Matrix side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63221; CAA44906.1; -; mRNA.
DR PIR; S28238; S28238.
DR RefSeq; NP_787004.1; NM_175810.2.
DR PDB; 5LC5; EM; 4.35 A; R=87-121.
DR PDB; 5LDW; EM; 4.27 A; R=87-121.
DR PDB; 5LDX; EM; 5.60 A; R=87-121.
DR PDB; 5LNK; EM; 3.90 A; b=29-124.
DR PDB; 5O31; EM; 4.13 A; R=29-124.
DR PDB; 7QSD; EM; 3.10 A; R=1-124.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5LNK; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; P23934; -.
DR SMR; P23934; -.
DR CORUM; P23934; -.
DR DIP; DIP-38815N; -.
DR IntAct; P23934; 2.
DR STRING; 9913.ENSBTAP00000047840; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR PaxDb; P23934; -.
DR PRIDE; P23934; -.
DR Ensembl; ENSBTAT00000013078; ENSBTAP00000013078; ENSBTAG00000009914.
DR GeneID; 327691; -.
DR KEGG; bta:327691; -.
DR CTD; 4726; -.
DR VEuPathDB; HostDB:ENSBTAG00000009914; -.
DR VGNC; VGNC:31971; NDUFS6.
DR eggNOG; KOG3456; Eukaryota.
DR GeneTree; ENSGT00390000015775; -.
DR HOGENOM; CLU_083053_3_2_1; -.
DR InParanoid; P23934; -.
DR OMA; VRFVNAK; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome 20.
DR Bgee; ENSBTAG00000009914; Expressed in tongue muscle and 109 other tissues.
DR ExpressionAtlas; P23934; baseline and differential.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR InterPro; IPR016668; NDUFS6.
DR InterPro; IPR019401; Znf_CHCC.
DR Pfam; PF10276; zf-CHCC; 1.
DR PIRSF; PIRSF016564; CI-13KD-A; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transit peptide; Transport.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:1907966"
FT CHAIN 29..124
FT /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT 6, mitochondrial"
FT /id="PRO_0000020019"
SQ SEQUENCE 124 AA; 13413 MW; B2537AEF5F901F22 CRC64;
MAAVLTFLRF LGRGGAVTRG LPGGARCFGV RTSPTGEKVT HTGQVYDDGD YRKVRFVGRQ
KEVNENFAID LIAEQPVSQV GSRVISCDGG GGALGHPRVY INLDKETKTG TCGYCGLQFR
QQHH
