ID   NDUS6_MACFA             Reviewed;         124 AA.
AC   Q4R5X8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;
DE   AltName: Full=Complex I-13kD-A;
DE            Short=CI-13kD-A;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 13 kDa-A subunit;
DE   Flags: Precursor;
GN   Name=NDUFS6; ORFNames=QtsA-19927;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC       is a component of the iron-sulfur (IP) fragment of the enzyme.
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O75380}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O75380}; Matrix side
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AB169414; BAE01497.1; -; mRNA.
DR   RefSeq; NP_001270954.1; NM_001284025.1.
DR   AlphaFoldDB; Q4R5X8; -.
DR   SMR; Q4R5X8; -.
DR   STRING; 9541.XP_005595540.1; -.
DR   GeneID; 101865852; -.
DR   CTD; 4726; -.
DR   eggNOG; KOG3456; Eukaryota.
DR   OrthoDB; 1641902at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR016668; NDUFS6.
DR   InterPro; IPR019401; Znf_CHCC.
DR   Pfam; PF10276; zf-CHCC; 1.
DR   PIRSF; PIRSF016564; CI-13KD-A; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transit peptide; Transport.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..124
FT                   /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT                   6, mitochondrial"
FT                   /id="PRO_0000043172"
FT   MOD_RES         98
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P52503"
SQ   SEQUENCE   124 AA;  13774 MW;  E98DDFC0693C3BC4 CRC64;
     MAASATFYRL LSRCGKAARS RPLGARCFGV RVSPTGEKIT HTGQVYDDKD YRRIRFVDRQ
     KEVNENFAID LIAEQPVSEV QTRVIACDGG GGALGHPKVY INLDKETKTG TCGYCGLQFR
     QHPH