ID   NDUS6_NEUCR             Reviewed;         104 AA.
AC   Q03015; Q7RVJ6;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial;
DE   AltName: Full=Complex I-12kD;
DE            Short=CI-12kD;
DE   Flags: Precursor;
GN   Name=nuo-12.3; ORFNames=NCU03093;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8098209; DOI=10.1042/bj2910729;
RA   Videira A., Azevedo J.E., Werner S., Cabral P.;
RT   "The 12.3 kDa subunit of complex I (respiratory-chain NADH dehydrogenase)
RT   from Neurospora crassa: cDNA cloning and chromosomal mapping of the gene.";
RL   Biochem. J. 291:729-732(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X68965; CAA48768.1; -; mRNA.
DR   EMBL; CM002236; EAA34627.1; -; Genomic_DNA.
DR   PIR; S32568; S32568.
DR   RefSeq; XP_963863.1; XM_958770.3.
DR   AlphaFoldDB; Q03015; -.
DR   SMR; Q03015; -.
DR   STRING; 5141.EFNCRP00000002922; -.
DR   TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   EnsemblFungi; EAA34627; EAA34627; NCU03093.
DR   GeneID; 3880012; -.
DR   KEGG; ncr:NCU03093; -.
DR   VEuPathDB; FungiDB:NCU03093; -.
DR   HOGENOM; CLU_142967_0_0_1; -.
DR   InParanoid; Q03015; -.
DR   OMA; GYQKNDP; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   InterPro; IPR039993; NDUFB10.
DR   PANTHER; PTHR13094; PTHR13094; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transit peptide; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT   CHAIN           ?..104
FT                   /note="NADH-ubiquinone oxidoreductase 12 kDa subunit,
FT                   mitochondrial"
FT                   /id="PRO_0000020023"
FT   CONFLICT        82
FT                   /note="L -> H (in Ref. 1; CAA48768)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   104 AA;  12281 MW;  AFF85601BD6BF68D CRC64;
     MPTPESAAFL AKKPTVPPTF DGVDYNDTKR LKQAQDAIIR EQWVRVMMGR LVREELSKCY
     YREGVNHLEK CGHLRERYLQ LLSENRVQGY LFEQQNHFAN QPKQ