ID   NDUS6_RAT               Reviewed;         116 AA.
AC   P52504;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;
DE   AltName: Full=Complex I-13kD-A;
DE            Short=CI-13kD-A;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 13 kDa-A subunit;
DE   Flags: Precursor;
GN   Name=Ndufs6; Synonyms=Ip13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=7607554; DOI=10.1016/0378-1119(95)00029-6;
RA   Watson J.D., Beckett-Jones B., Roy R.N., Green N.C., Flynn T.G.;
RT   "Genomic sequence, structural organization and evolutionary conservation of
RT   the 13.2-kDa subunit of rat NADH:ubiquinone oxidoreductase.";
RL   Gene 158:275-280(1995).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC       is a component of the iron-sulfur (IP) fragment of the enzyme.
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O75380}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O75380}; Matrix side
CC       {ECO:0000250|UniProtKB:O75380}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; L38437; AAA79310.1; -; Genomic_DNA.
DR   PIR; JC4129; JC4129.
DR   RefSeq; NP_062096.1; NM_019223.1.
DR   AlphaFoldDB; P52504; -.
DR   SMR; P52504; -.
DR   BioGRID; 248120; 1.
DR   IntAct; P52504; 1.
DR   MINT; P52504; -.
DR   STRING; 10116.ENSRNOP00000036045; -.
DR   iPTMnet; P52504; -.
DR   jPOST; P52504; -.
DR   PaxDb; P52504; -.
DR   PRIDE; P52504; -.
DR   GeneID; 29478; -.
DR   KEGG; rno:29478; -.
DR   UCSC; RGD:3156; rat.
DR   CTD; 4726; -.
DR   RGD; 3156; Ndufs6.
DR   eggNOG; KOG3456; Eukaryota.
DR   InParanoid; P52504; -.
DR   OrthoDB; 1641902at2759; -.
DR   PhylomeDB; P52504; -.
DR   PRO; PR:P52504; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0072359; P:circulatory system development; ISO:RGD.
DR   GO; GO:0006631; P:fatty acid metabolic process; ISO:RGD.
DR   GO; GO:0001822; P:kidney development; ISO:RGD.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:RGD.
DR   GO; GO:0070584; P:mitochondrion morphogenesis; ISO:RGD.
DR   GO; GO:0010259; P:multicellular organism aging; ISO:RGD.
DR   GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR   GO; GO:0006936; P:muscle contraction; ISO:RGD.
DR   GO; GO:0061458; P:reproductive system development; ISO:RGD.
DR   GO; GO:0022904; P:respiratory electron transport chain; ISO:RGD.
DR   InterPro; IPR016668; NDUFS6.
DR   InterPro; IPR019401; Znf_CHCC.
DR   Pfam; PF10276; zf-CHCC; 1.
DR   PIRSF; PIRSF016564; CI-13KD-A; 1.
PE   3: Inferred from homology;
KW   Acetylation; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transit peptide; Transport.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..116
FT                   /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT                   6, mitochondrial"
FT                   /id="PRO_0000020021"
FT   MOD_RES         90
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P52503"
SQ   SEQUENCE   116 AA;  12783 MW;  75BD98306D1A4487 CRC64;
     MAAALTFRRL LALPRAARGF GVRVSLSGEK ITHTGQVSDG KDYRGIRFVD RQKEVNENFA
     IDLIAQQPVN EVDRRIIACD GGGGALGHPK VYINLDKETK TGTCAYCGLQ FKQQHH