ID   NDUV3_BOVIN             Reviewed;         109 AA.
AC   P25712; Q3SZ08;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;
DE   AltName: Full=Complex I-9kD;
DE            Short=CI-9kD;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 9 kDa subunit;
DE   Flags: Precursor;
GN   Name=NDUFV3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=1902801; DOI=10.1016/0014-5793(91)80462-c;
RA   Skehel J.M., Pilkington S.J., Runswick M.J., Fearnley I.M., Walker J.E.;
RT   "NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA
RT   sequence of the import precursor of the 10 kDa subunit of the flavoprotein
RT   fragment.";
RL   FEBS Lett. 282:135-138(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 35-109.
RX   PubMed=1778979; DOI=10.1093/oxfordjournals.jbchem.a123622;
RA   Masui R., Wakabayashi S., Matsubara H., Hatefi Y.;
RT   "The amino acid sequence of the 9 kDa polypeptide and partial amino acid
RT   sequence of the 20 kDa polypeptide of mitochondrial NADH:ubiquinone
RT   oxidoreductase.";
RL   J. Biochem. 110:575-582(1991).
RN   [4]
RP   SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX   PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA   Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA   Robinson N.C.;
RT   "Subunit analysis of bovine heart complex I by reversed-phase high-
RT   performance liquid chromatography, electrospray ionization-tandem mass
RT   spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT   flight mass spectrometry.";
RL   Anal. Biochem. 382:116-121(2008).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone. May be the terminally
CC       assembled subunit of Complex I. {ECO:0000250|UniProtKB:P56181}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This is a
CC       component of the flavoprotein-sulfur (FP) fragment of the enzyme.
CC       {ECO:0000269|PubMed:18721790}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000305|PubMed:18721790}; Peripheral membrane protein
CC       {ECO:0000305}; Matrix side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFV3 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X59048; CAA41775.1; -; mRNA.
DR   EMBL; BC103274; AAI03275.1; -; mRNA.
DR   PIR; S15107; S15107.
DR   RefSeq; NP_787024.1; NM_175830.1.
DR   PDB; 5LNK; EM; 3.90 A; a=35-109.
DR   PDB; 5O31; EM; 4.13 A; s=35-109.
DR   PDB; 7QSD; EM; 3.10 A; s=1-109.
DR   PDBsum; 5LNK; -.
DR   PDBsum; 5O31; -.
DR   PDBsum; 7QSD; -.
DR   AlphaFoldDB; P25712; -.
DR   SMR; P25712; -.
DR   CORUM; P25712; -.
DR   DIP; DIP-38824N; -.
DR   IntAct; P25712; 2.
DR   STRING; 9913.ENSBTAP00000041265; -.
DR   TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   PaxDb; P25712; -.
DR   PRIDE; P25712; -.
DR   GeneID; 327717; -.
DR   KEGG; bta:327717; -.
DR   CTD; 4731; -.
DR   eggNOG; ENOG502S46A; Eukaryota.
DR   HOGENOM; CLU_2157565_0_0_1; -.
DR   InParanoid; P25712; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR   GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IBA:GO_Central.
DR   InterPro; IPR026193; NDUFV3.
DR   PANTHER; PTHR17117; PTHR17117; 2.
DR   Pfam; PF15880; NDUFV3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW   Reference proteome; Respiratory chain; Transit peptide; Transport.
FT   TRANSIT         1..34
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:1778979"
FT   CHAIN           35..109
FT                   /note="NADH dehydrogenase [ubiquinone] flavoprotein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000020024"
FT   REGION          33..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         106
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56181"
FT   CONFLICT        48
FT                   /note="N -> D (in Ref. 2; AAI03275)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  11857 MW;  A49719C74AC1AC70 CRC64;
     MAASLLLRQG RAGALKTVLL EAGVFRGVAP AVSLSAESGK NEKGLPPNPK KQSPPKKPVS
     AAPTEPFDNT TYKNLQHHDY STYTFLDLNL DLSKFRMPQP SSGRESPRH