NDUV3_MOUSE
ID NDUV3_MOUSE Reviewed; 104 AA.
AC Q8BK30;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial;
DE AltName: Full=Complex I-9kD;
DE Short=CI-9kD;
DE AltName: Full=NADH-ubiquinone oxidoreductase 9 kDa subunit;
DE Flags: Precursor;
GN Name=Ndufv3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone. May be the terminally
CC assembled subunit of Complex I. {ECO:0000250|UniProtKB:P56181}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. This is a
CC component of the flavoprotein-sulfur (FP) fragment of the enzyme.
CC {ECO:0000250|UniProtKB:P56181}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P56181}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P56181}; Matrix side
CC {ECO:0000250|UniProtKB:P56181}.
CC -!- SIMILARITY: Belongs to the complex I NDUFV3 subunit family.
CC {ECO:0000305}.
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DR EMBL; AK077433; BAC36798.1; -; mRNA.
DR CCDS; CCDS37550.1; -.
DR RefSeq; NP_001077360.1; NM_001083891.1.
DR PDB; 6G2J; EM; 3.30 A; s=1-104.
DR PDB; 6G72; EM; 3.90 A; s=1-104.
DR PDB; 6ZR2; EM; 3.10 A; s=1-104.
DR PDB; 6ZTQ; EM; 3.00 A; s=1-104.
DR PDB; 7AK5; EM; 3.17 A; s=1-104.
DR PDB; 7AK6; EM; 3.82 A; s=1-104.
DR PDB; 7B93; EM; 3.04 A; s=1-104.
DR PDB; 7PSA; EM; 3.40 A; s=1-104.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; Q8BK30; -.
DR SMR; Q8BK30; -.
DR BioGRID; 219334; 45.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR IntAct; Q8BK30; 1.
DR STRING; 10090.ENSMUSP00000049000; -.
DR iPTMnet; Q8BK30; -.
DR PhosphoSitePlus; Q8BK30; -.
DR EPD; Q8BK30; -.
DR jPOST; Q8BK30; -.
DR MaxQB; Q8BK30; -.
DR PaxDb; Q8BK30; -.
DR PeptideAtlas; Q8BK30; -.
DR PRIDE; Q8BK30; -.
DR ProteomicsDB; 253050; -.
DR Antibodypedia; 9794; 158 antibodies from 27 providers.
DR DNASU; 78330; -.
DR Ensembl; ENSMUST00000064798; ENSMUSP00000066303; ENSMUSG00000024038.
DR GeneID; 78330; -.
DR KEGG; mmu:78330; -.
DR UCSC; uc008bvf.1; mouse.
DR CTD; 4731; -.
DR MGI; MGI:1890894; Ndufv3.
DR VEuPathDB; HostDB:ENSMUSG00000024038; -.
DR eggNOG; ENOG502S46A; Eukaryota.
DR GeneTree; ENSGT00390000012196; -.
DR HOGENOM; CLU_2157565_0_0_1; -.
DR InParanoid; Q8BK30; -.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 78330; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ndufv3; mouse.
DR PRO; PR:Q8BK30; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8BK30; protein.
DR Bgee; ENSMUSG00000024038; Expressed in heart right ventricle and 264 other tissues.
DR ExpressionAtlas; Q8BK30; baseline and differential.
DR Genevisible; Q8BK30; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; ISO:MGI.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR InterPro; IPR026193; NDUFV3.
DR PANTHER; PTHR17117; PTHR17117; 2.
DR Pfam; PF15880; NDUFV3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transit peptide; Transport.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 36..104
FT /note="NADH dehydrogenase [ubiquinone] flavoprotein 3,
FT mitochondrial"
FT /id="PRO_0000251883"
FT REGION 38..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56181"
FT HELIX 71..74
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 79..90
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:6ZTQ"
SQ SEQUENCE 104 AA; 11813 MW; 0674772FC8C17CA6 CRC64;
MAVSLLLRGG RIRALKAVLL EARVFPGELV SVVRLSTESE KSAKEKELHP KTQSVLKEPE
PTDTTTYKNL QHHDYNTYTF LDLNLDLSKF RLPQPSSGRE SPRH
