NDX1_ARATH
ID NDX1_ARATH Reviewed; 282 AA.
AC Q8GWB2; Q9C7E3;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein NEOXANTHIN-DEFICIENT 1 {ECO:0000303|PubMed:24506237};
GN Name=NDX1 {ECO:0000303|PubMed:24506237};
GN OrderedLocusNames=At1g28100 {ECO:0000312|Araport:AT1G28100};
GN ORFNames=F13K9.27 {ECO:0000312|EMBL:AAG51493.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24506237; DOI=10.1111/tpj.12451;
RA Neuman H., Galpaz N., Cunningham F.X. Jr., Zamir D., Hirschberg J.;
RT "The tomato mutation nxd1 reveals a gene necessary for neoxanthin
RT biosynthesis and demonstrates that violaxanthin is a sufficient precursor
RT for abscisic acid biosynthesis.";
RL Plant J. 78:80-93(2014).
CC -!- FUNCTION: Required for neoxanthin biosynthesis. Probably not involved
CC directly in the enzymatic conversion of violaxanthin to neoxanthin. Is
CC necessary but not sufficient for neoxanthin synthesis.
CC {ECO:0000269|PubMed:24506237}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=Q8GWB2-1; Sequence=Displayed;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants lack neoxanthin.
CC {ECO:0000269|PubMed:24506237}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51493.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC069471; AAG51493.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30913.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30914.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30915.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM57859.1; -; Genomic_DNA.
DR EMBL; AK118960; BAC43539.1; -; mRNA.
DR EMBL; BT005547; AAO63967.1; -; mRNA.
DR EMBL; AK317602; BAH20265.1; -; mRNA.
DR PIR; G86406; G86406.
DR RefSeq; NP_001320339.1; NM_001332801.1. [Q8GWB2-1]
DR RefSeq; NP_174131.3; NM_102575.3. [Q8GWB2-1]
DR RefSeq; NP_849717.1; NM_179386.2. [Q8GWB2-1]
DR RefSeq; NP_973925.2; NM_202196.3. [Q8GWB2-1]
DR AlphaFoldDB; Q8GWB2; -.
DR STRING; 3702.AT1G28100.4; -.
DR PaxDb; Q8GWB2; -.
DR PRIDE; Q8GWB2; -.
DR DNASU; 839703; -.
DR EnsemblPlants; AT1G28100.1; AT1G28100.1; AT1G28100. [Q8GWB2-1]
DR EnsemblPlants; AT1G28100.2; AT1G28100.2; AT1G28100. [Q8GWB2-1]
DR EnsemblPlants; AT1G28100.3; AT1G28100.3; AT1G28100. [Q8GWB2-1]
DR EnsemblPlants; AT1G28100.6; AT1G28100.6; AT1G28100. [Q8GWB2-1]
DR GeneID; 839703; -.
DR Gramene; AT1G28100.1; AT1G28100.1; AT1G28100. [Q8GWB2-1]
DR Gramene; AT1G28100.2; AT1G28100.2; AT1G28100. [Q8GWB2-1]
DR Gramene; AT1G28100.3; AT1G28100.3; AT1G28100. [Q8GWB2-1]
DR Gramene; AT1G28100.6; AT1G28100.6; AT1G28100. [Q8GWB2-1]
DR KEGG; ath:AT1G28100; -.
DR Araport; AT1G28100; -.
DR eggNOG; ENOG502QU37; Eukaryota.
DR PhylomeDB; Q8GWB2; -.
DR PRO; PR:Q8GWB2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GWB2; baseline and differential.
DR GO; GO:0016123; P:xanthophyll biosynthetic process; IMP:UniProtKB.
DR Gene3D; 2.40.400.10; -; 1.
DR InterPro; IPR023375; ADC_dom_sf.
DR InterPro; IPR039343; NDX1-like.
DR PANTHER; PTHR35467; PTHR35467; 1.
DR SUPFAM; SSF160104; SSF160104; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..282
FT /note="Protein NEOXANTHIN-DEFICIENT 1"
FT /id="PRO_0000435895"
SQ SEQUENCE 282 AA; 31169 MW; DFA02DCE5EC3055F CRC64;
MDVEEKRVSS GYAKPPWIFK GSALYQIHLV KAATARAFIP KEFRLVEAFG YTLGGFFLAS
YDDSPAGVFD ELVVIAGIVW NPPTSCAWAA RVLVNSDEAC HHGRKEVGLP SQVARFSKNI
TAVPKQKRDR AFGFLDTFGL GTTLSHPENL MEVKVSEVDS AASTDICNIQ IRSDETKVGN
WMGPAIKMAL PSFSGNTIYN SNLLKYSCHL HCRVRPVRPA VVSGALEDET EKFTEQNHTS
QESLENERQL SKAVMLSKPI IALQFKCLTM QVEAPVVIYP SK
