ID   NDX1_SOLLC              Reviewed;         295 AA.
AC   K4DEY3;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Protein NEOXANTHIN-DEFICIENT 1 {ECO:0000303|PubMed:24506237};
GN   Name=NXD1 {ECO:0000303|PubMed:24506237};
GN   OrderedLocusNames=Solyc12g041880.1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Heinz 1706;
RX   PubMed=22660326; DOI=10.1038/nature11119;
RG   Tomato Genome Consortium;
RT   "The tomato genome sequence provides insights into fleshy fruit
RT   evolution.";
RL   Nature 485:635-641(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24506237; DOI=10.1111/tpj.12451;
RA   Neuman H., Galpaz N., Cunningham F.X. Jr., Zamir D., Hirschberg J.;
RT   "The tomato mutation nxd1 reveals a gene necessary for neoxanthin
RT   biosynthesis and demonstrates that violaxanthin is a sufficient precursor
RT   for abscisic acid biosynthesis.";
RL   Plant J. 78:80-93(2014).
CC   -!- FUNCTION: Required for neoxanthin biosynthesis. Probably not involved
CC       directly in the enzymatic conversion of violaxanthin to neoxanthin. Is
CC       necessary but not sufficient for neoxanthin synthesis. Seems not
CC       required for abscisic acid (ABA) biosynthesis in response to drought
CC       stress. {ECO:0000269|PubMed:24506237}.
CC   -!- DISRUPTION PHENOTYPE: Pale yellow flowers. Absence of neoxanthin and
CC       reduction by half of xanthophyll levels in petals.
CC       {ECO:0000269|PubMed:24506237}.
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DR   RefSeq; NP_001316023.1; NM_001329094.1.
DR   AlphaFoldDB; K4DEY3; -.
DR   STRING; 4081.Solyc12g041880.1.1; -.
DR   PaxDb; K4DEY3; -.
DR   PRIDE; K4DEY3; -.
DR   EnsemblPlants; Solyc12g041880.2.1; Solyc12g041880.2.1; Solyc12g041880.2.
DR   GeneID; 101248551; -.
DR   Gramene; Solyc12g041880.2.1; Solyc12g041880.2.1; Solyc12g041880.2.
DR   KEGG; sly:101248551; -.
DR   eggNOG; ENOG502QU37; Eukaryota.
DR   HOGENOM; CLU_068991_0_0_1; -.
DR   InParanoid; K4DEY3; -.
DR   OMA; HLCNISV; -.
DR   OrthoDB; 1433550at2759; -.
DR   PhylomeDB; K4DEY3; -.
DR   Proteomes; UP000004994; Chromosome 12.
DR   GO; GO:0016123; P:xanthophyll biosynthetic process; IMP:UniProtKB.
DR   Gene3D; 2.40.400.10; -; 1.
DR   InterPro; IPR023375; ADC_dom_sf.
DR   InterPro; IPR039343; NDX1-like.
DR   PANTHER; PTHR35467; PTHR35467; 1.
DR   SUPFAM; SSF160104; SSF160104; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..295
FT                   /note="Protein NEOXANTHIN-DEFICIENT 1"
FT                   /id="PRO_0000435897"
FT   REGION          221..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  32376 MW;  4E93C13B3CB09EBE CRC64;
     MEVKDTNCTS LGYGKPPWIF KGSALYQLHL VKAENARAFI PKECKLVEAF GYTLGGFFLA
     SYDDSPAGIF DELVVIAGLV WNPPTSCAWA ARVLVGSDEA CLHGRKVVGL PSQVARFSKK
     ITALPQKPES KSSSFLRRIG LRTSSNYKNH MDVEVTEIKK QTAMSICNIN VNATASQQDS
     KGWMGPLIKM SLPNFSGRTK YNSDLLKYSC QIECRVRAVQ PAKVSGPSES DADKENSSED
     QSSNVESVSR VPRGTKRNFS ISVMLSKPIL ALEFNHLKMR VEAPTTVTAC SHDTT