ID   NDX6_CAEEL              Reviewed;         260 AA.
AC   Q09297;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Putative nudix hydrolase 6;
DE            EC=3.-.-.-;
GN   Name=ndx-6; ORFNames=EEED8.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC       diphosphate derivatives. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; FO081042; CCD68736.1; -; Genomic_DNA.
DR   PIR; T15918; T15918.
DR   RefSeq; NP_495015.1; NM_062614.3.
DR   AlphaFoldDB; Q09297; -.
DR   SMR; Q09297; -.
DR   BioGRID; 39260; 5.
DR   STRING; 6239.EEED8.8; -.
DR   EPD; Q09297; -.
DR   PaxDb; Q09297; -.
DR   PeptideAtlas; Q09297; -.
DR   EnsemblMetazoa; EEED8.8.1; EEED8.8.1; WBGene00003583.
DR   GeneID; 173916; -.
DR   KEGG; cel:CELE_EEED8.8; -.
DR   UCSC; EEED8.8; c. elegans.
DR   CTD; 173916; -.
DR   WormBase; EEED8.8; CE27911; WBGene00003583; ndx-6.
DR   eggNOG; KOG4195; Eukaryota.
DR   GeneTree; ENSGT00390000017405; -.
DR   HOGENOM; CLU_067226_0_0_1; -.
DR   InParanoid; Q09297; -.
DR   OMA; PQWNQLD; -.
DR   OrthoDB; 1186086at2759; -.
DR   PhylomeDB; Q09297; -.
DR   Reactome; R-CEL-2393930; Phosphate bond hydrolysis by NUDT proteins.
DR   PRO; PR:Q09297; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003583; Expressed in embryo and 4 other tissues.
DR   GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR039989; NUDT9.
DR   PANTHER; PTHR13030; PTHR13030; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..260
FT                   /note="Putative nudix hydrolase 6"
FT                   /id="PRO_0000057136"
FT   DOMAIN          113..257
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           148..170
FT                   /note="Nudix box"
FT   BINDING         163
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         167
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   260 AA;  29281 MW;  1B5160588D6BEE3B CRC64;
     MSFVHQKCRN IDTVYLGSNI HRLNVPDNLV KWSQEWSGYN PPAHTDPKVD GAVWADPEID
     EKTFQPSWNA IDGKINRVSY VCQYSFDPVT LRPLNPIGRT GLSGRGLLGR WGPNHAADPI
     VSRTNDNGDL EFVAVQRHDN GEWAIPGGMV DAGEHVSQTL RREFAEEAMH GIVDSENLDE
     LWNNGKELYR GYVDDPRNTD NAWMETVVFN FHDSKGLLKN VALQAGDDAK ALRWIAVNSN
     EPLYASHSHF IDLLKESHSH