NEBU_HUMAN
ID NEBU_HUMAN Reviewed; 6669 AA.
AC P20929; F8WCL5; F8WCP0; Q15346; Q53QQ2; Q53TG8;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 5.
DT 03-AUG-2022, entry version 203.
DE RecName: Full=Nebulin;
GN Name=NEB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND VARIANTS ASN-1027; HIS-1301;
RP MET-1491; CYS-3360; THR-4401 AND VAL-6546.
RX PubMed=7739042; DOI=10.1016/s0022-2836(95)80052-2;
RA Labeit S., Kolmerer B.;
RT "The complete primary structure of human nebulin and its correlation to
RT muscle structure.";
RL J. Mol. Biol. 248:308-315(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6263-6329.
RX PubMed=1682316; DOI=10.1016/s0021-9258(18)54843-2;
RA Jin J.P., Wang K.;
RT "Cloning, expression, and protein interaction of human nebulin fragments
RT composed of varying numbers of sequence modules.";
RL J. Biol. Chem. 266:21215-21223(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1811-1939.
RX PubMed=3397062; DOI=10.1016/0888-7543(88)90009-2;
RA Zeviani M., Darras B.T., Rizzuto R., Salviati G., Betto R., Bonilla E.,
RA Miranda A.F., Du J., Samitt C., Dickson G., Walsh F.S., Dimauro S.,
RA Francke U., Schon E.A.;
RT "Cloning and expression of human nebulin cDNAs and assignment of the gene
RT to chromosome 2q31-q32.";
RL Genomics 2:249-256(1988).
RN [5]
RP INTERACTION WITH TTN.
RX PubMed=12482578; DOI=10.1016/s0014-5793(02)03655-4;
RA Ma K., Wang K.;
RT "Interaction of nebulin SH3 domain with titin PEVK and myopalladin:
RT implications for the signaling and assembly role of titin and nebulin.";
RL FEBS Lett. 532:273-278(2002).
RN [6]
RP SUBUNIT, AND INTERACTION WITH DES.
RX PubMed=23615443; DOI=10.1091/mbc.e12-11-0840;
RA Baker L.K., Gillis D.C., Sharma S., Ambrus A., Herrmann H., Conover G.M.;
RT "Nebulin binding impedes mutant desmin filament assembly.";
RL Mol. Biol. Cell 24:1918-1932(2013).
RN [7]
RP STRUCTURE BY NMR OF 6610-6669.
RX PubMed=9514727; DOI=10.1006/jmbi.1997.1521;
RA Politou A.S., Millevoi S., Gautel M., Kolmerer B., Pastore A.;
RT "SH3 in muscles: solution structure of the SH3 domain from nebulin.";
RL J. Mol. Biol. 276:189-202(1998).
RN [8]
RP INVOLVEMENT IN NEM2, AND INVOLVEMENT IN AMC6.
RX PubMed=10051637; DOI=10.1073/pnas.96.5.2305;
RA Pelin K., Hilpelae P., Donner K., Sewry C., Akkari P.A., Wilton S.D.,
RA Wattanasirichaigoon D., Bang M.-L., Centner T., Hanefeld F., Odent S.,
RA Fardeau M., Urtizberea J.A., Muntoni F., Dubowitz V., Beggs A.H.,
RA Laing N.G., Labeit S., de la Chapelle A., Wallgren-Pettersson C.;
RT "Mutations in the nebulin gene associated with autosomal recessive nemaline
RT myopathy.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:2305-2310(1999).
RN [9]
RP INVOLVEMENT IN AMC6.
RX PubMed=21798101; DOI=10.1186/2044-5040-1-23;
RA Lawlor M.W., Ottenheijm C.A., Lehtokari V.L., Cho K., Pelin K.,
RA Wallgren-Pettersson C., Granzier H., Beggs A.H.;
RT "Novel mutations in NEB cause abnormal nebulin expression and markedly
RT impaired muscle force generation in severe nemaline myopathy.";
RL Skelet. Muscle 1:23-23(2011).
RN [10]
RP INTERACTION WITH SVIL.
RX PubMed=18639526; DOI=10.1016/j.bbrc.2008.07.036;
RA Lee M.-A., Joo Y.M., Lee Y.M., Kim H.S., Kim J.-H., Choi J.-K., Ahn S.-J.,
RA Min B.-I., Kim C.-R.;
RT "Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-
RT terminus.";
RL Biochem. Biophys. Res. Commun. 374:320-324(2008).
RN [11]
RP VARIANT AMC6 974-ARG--ILE-6669 DEL, AND INVOLVEMENT IN AMC6.
RX PubMed=26578207; DOI=10.1186/s13023-015-0364-0;
RA Todd E.J., Yau K.S., Ong R., Slee J., McGillivray G., Barnett C.P.,
RA Haliloglu G., Talim B., Akcoren Z., Kariminejad A., Cairns A., Clarke N.F.,
RA Freckmann M.L., Romero N.B., Williams D., Sewry C.A., Colley A., Ryan M.M.,
RA Kiraly-Borri C., Sivadorai P., Allcock R.J., Beeson D., Maxwell S.,
RA Davis M.R., Laing N.G., Ravenscroft G.;
RT "Next generation sequencing in a large cohort of patients presenting with
RT neuromuscular disease before or at birth.";
RL Orphanet J. Rare Dis. 10:148-148(2015).
RN [12]
RP VARIANTS AMC6 4561-TYR--ILE-6669 DEL AND 4626-TYR--ILE-6669 DEL, AND
RP INVOLVEMENT IN AMC6.
RX PubMed=29274205; DOI=10.1002/ajmg.a.38577;
RA Ahmed A.A., Skaria P., Safina N.P., Thiffault I., Kats A., Taboada E.,
RA Habeebu S., Saunders C.;
RT "Arthrogryposis and pterygia as lethal end manifestations of genetically
RT defined congenital myopathies.";
RL Am. J. Med. Genet. A 176:359-367(2018).
CC -!- FUNCTION: This giant muscle protein may be involved in maintaining the
CC structural integrity of sarcomeres and the membrane system associated
CC with the myofibrils. Binds and stabilize F-actin.
CC -!- SUBUNIT: Monomer and homooligomer (PubMed:23615443). Interacts with
CC TTN/titin (PubMed:12482578). Interacts with SVIL (PubMed:18639526).
CC Interacts (via nebulin repeats 160-164) with DES (PubMed:23615443).
CC {ECO:0000269|PubMed:12482578, ECO:0000269|PubMed:18639526,
CC ECO:0000269|PubMed:23615443}.
CC -!- INTERACTION:
CC P20929; O75923: DYSF; NbExp=6; IntAct=EBI-1049657, EBI-2799016;
CC P20929; O60662: KLHL41; NbExp=8; IntAct=EBI-1049657, EBI-5353084;
CC P20929; Q86TC9: MYPN; NbExp=2; IntAct=EBI-1049657, EBI-2562606;
CC P20929; Q07889: SOS1; NbExp=3; IntAct=EBI-1049657, EBI-297487;
CC P20929; O95425: SVIL; NbExp=4; IntAct=EBI-1049657, EBI-487145;
CC P20929; Q8WZ42: TTN; NbExp=6; IntAct=EBI-1049657, EBI-681210;
CC P20929-4; O60662: KLHL41; NbExp=5; IntAct=EBI-9531519, EBI-5353084;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere. Cytoplasm,
CC cytoskeleton.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=P20929-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P20929-2; Sequence=VSP_054445, VSP_054446, VSP_054447,
CC VSP_054448;
CC Name=3;
CC IsoId=P20929-3; Sequence=VSP_054445, VSP_054446, VSP_054448;
CC Name=4;
CC IsoId=P20929-4; Sequence=VSP_054444;
CC -!- TISSUE SPECIFICITY: Muscle specific. Located in the thin filament of
CC striated muscle.
CC -!- DISEASE: Nemaline myopathy 2 (NEM2) [MIM:256030]: A form of nemaline
CC myopathy. Nemaline myopathies are muscular disorders characterized by
CC muscle weakness of varying severity and onset, and abnormal thread-like
CC or rod-shaped structures in muscle fibers on histologic examination.
CC {ECO:0000269|PubMed:10051637}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Arthrogryposis multiplex congenita 6 (AMC6) [MIM:619334]: A
CC form of arthrogryposis multiplex congenita, a developmental condition
CC characterized by multiple joint contractures resulting from reduced or
CC absent fetal movements. AMC6 is an autosomal recessive lethal form.
CC Death usually occurs in utero or in infancy.
CC {ECO:0000269|PubMed:10051637, ECO:0000269|PubMed:21798101,
CC ECO:0000269|PubMed:26578207, ECO:0000269|PubMed:29274205}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X83957; CAA58788.1; -; mRNA.
DR EMBL; AC009497; AAY14651.1; -; Genomic_DNA.
DR EMBL; AC107052; AAY14977.1; -; Genomic_DNA.
DR EMBL; AC116650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M19669; AAA59917.1; -; mRNA.
DR CCDS; CCDS46424.1; -. [P20929-4]
DR CCDS; CCDS54407.1; -. [P20929-2]
DR CCDS; CCDS54408.1; -. [P20929-3]
DR PIR; A29979; A29979.
DR PIR; B29979; B29979.
DR PIR; S55024; S55024.
DR RefSeq; NP_004534.2; NM_004543.4. [P20929-4]
DR PDB; 1ARK; NMR; -; A=6610-6669.
DR PDB; 1NEB; NMR; -; A=6610-6669.
DR PDB; 6Y17; X-ray; 1.56 A; C/D=6610-6669.
DR PDBsum; 1ARK; -.
DR PDBsum; 1NEB; -.
DR PDBsum; 6Y17; -.
DR SMR; P20929; -.
DR BioGRID; 110783; 54.
DR IntAct; P20929; 36.
DR MINT; P20929; -.
DR CarbonylDB; P20929; -.
DR GlyGen; P20929; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P20929; -.
DR PhosphoSitePlus; P20929; -.
DR BioMuta; NEB; -.
DR DMDM; 313104310; -.
DR EPD; P20929; -.
DR jPOST; P20929; -.
DR MassIVE; P20929; -.
DR PeptideAtlas; P20929; -.
DR PRIDE; P20929; -.
DR ProteomicsDB; 31194; -.
DR ProteomicsDB; 31219; -.
DR ProteomicsDB; 53825; -. [P20929-1]
DR Antibodypedia; 1171; 128 antibodies from 26 providers.
DR DNASU; 4703; -.
DR Ensembl; ENST00000397345.8; ENSP00000380505.3; ENSG00000183091.21. [P20929-2]
DR Ensembl; ENST00000409198.5; ENSP00000386259.1; ENSG00000183091.21. [P20929-4]
DR Ensembl; ENST00000427231.7; ENSP00000416578.2; ENSG00000183091.21. [P20929-3]
DR GeneID; 4703; -.
DR KEGG; hsa:4703; -.
DR MANE-Select; ENST00000397345.8; ENSP00000380505.3; NM_001164508.2; NP_001157980.2. [P20929-2]
DR UCSC; uc002txu.3; human. [P20929-1]
DR CTD; 4703; -.
DR DisGeNET; 4703; -.
DR GeneCards; NEB; -.
DR HGNC; HGNC:7720; NEB.
DR HPA; ENSG00000183091; Group enriched (skeletal muscle, tongue).
DR MalaCards; NEB; -.
DR MIM; 161650; gene.
DR MIM; 256030; phenotype.
DR MIM; 619334; phenotype.
DR neXtProt; NX_P20929; -.
DR OpenTargets; ENSG00000183091; -.
DR Orphanet; 171439; Childhood-onset nemaline myopathy.
DR Orphanet; 399103; Distal nebulin myopathy.
DR Orphanet; 171433; Intermediate nemaline myopathy.
DR Orphanet; 33108; Lethal multiple pterygium syndrome.
DR Orphanet; 171430; Severe congenital nemaline myopathy.
DR Orphanet; 171436; Typical nemaline myopathy.
DR PharmGKB; PA31530; -.
DR VEuPathDB; HostDB:ENSG00000183091; -.
DR GeneTree; ENSGT00940000154533; -.
DR HOGENOM; CLU_000024_0_0_1; -.
DR InParanoid; P20929; -.
DR OMA; GNFKYTC; -.
DR OrthoDB; 1549538at2759; -.
DR TreeFam; TF319104; -.
DR PathwayCommons; P20929; -.
DR Reactome; R-HSA-390522; Striated Muscle Contraction.
DR SignaLink; P20929; -.
DR SIGNOR; P20929; -.
DR BioGRID-ORCS; 4703; 12 hits in 1065 CRISPR screens.
DR ChiTaRS; NEB; human.
DR EvolutionaryTrace; P20929; -.
DR GenomeRNAi; 4703; -.
DR Pharos; P20929; Tbio.
DR PRO; PR:P20929; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P20929; protein.
DR Bgee; ENSG00000183091; Expressed in gluteal muscle and 124 other tissues.
DR ExpressionAtlas; P20929; baseline and differential.
DR Genevisible; P20929; HS.
DR GO; GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0030018; C:Z disc; IDA:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
DR GO; GO:0071691; P:cardiac muscle thin filament assembly; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; TAS:ProtInc.
DR GO; GO:0030832; P:regulation of actin filament length; NAS:UniProtKB.
DR GO; GO:0007525; P:somatic muscle development; NAS:UniProtKB.
DR CDD; cd11933; SH3_Nebulin_C; 1.
DR InterPro; IPR013998; Nebulin-like.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR035629; Nebulin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00880; Nebulin; 63.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00510; NEBULIN.
DR SMART; SM00227; NEBU; 181.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS51216; NEBULIN; 181.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW Disease variant; Muscle protein; Nemaline myopathy; Reference proteome;
KW Repeat; SH3 domain.
FT CHAIN 1..6669
FT /note="Nebulin"
FT /id="PRO_0000096775"
FT REPEAT 76..107
FT /note="Nebulin 1"
FT REPEAT 113..143
FT /note="Nebulin 2"
FT REPEAT 148..178
FT /note="Nebulin 3"
FT REPEAT 183..213
FT /note="Nebulin 4"
FT REPEAT 218..248
FT /note="Nebulin 5"
FT REPEAT 253..283
FT /note="Nebulin 6"
FT REPEAT 289..318
FT /note="Nebulin 7"
FT REPEAT 324..354
FT /note="Nebulin 8"
FT REPEAT 363..393
FT /note="Nebulin 9"
FT REPEAT 398..428
FT /note="Nebulin 10"
FT REPEAT 434..464
FT /note="Nebulin 11"
FT REPEAT 502..532
FT /note="Nebulin 12"
FT REPEAT 537..567
FT /note="Nebulin 13"
FT REPEAT 573..603
FT /note="Nebulin 14"
FT REPEAT 611..641
FT /note="Nebulin 15"
FT REPEAT 681..711
FT /note="Nebulin 16"
FT REPEAT 749..779
FT /note="Nebulin 17"
FT REPEAT 784..814
FT /note="Nebulin 18"
FT REPEAT 820..850
FT /note="Nebulin 19"
FT REPEAT 858..888
FT /note="Nebulin 20"
FT REPEAT 893..923
FT /note="Nebulin 21"
FT REPEAT 924..954
FT /note="Nebulin 22"
FT REPEAT 959..990
FT /note="Nebulin 23"
FT REPEAT 993..1023
FT /note="Nebulin 24"
FT REPEAT 1028..1058
FT /note="Nebulin 25"
FT REPEAT 1064..1094
FT /note="Nebulin 26"
FT REPEAT 1102..1132
FT /note="Nebulin 27"
FT REPEAT 1137..1167
FT /note="Nebulin 28"
FT REPEAT 1168..1198
FT /note="Nebulin 29"
FT REPEAT 1204..1234
FT /note="Nebulin 30"
FT REPEAT 1237..1267
FT /note="Nebulin 31"
FT REPEAT 1272..1302
FT /note="Nebulin 32"
FT REPEAT 1308..1338
FT /note="Nebulin 33"
FT REPEAT 1346..1376
FT /note="Nebulin 34"
FT REPEAT 1381..1411
FT /note="Nebulin 35"
FT REPEAT 1412..1442
FT /note="Nebulin 36"
FT REPEAT 1448..1478
FT /note="Nebulin 37"
FT REPEAT 1481..1511
FT /note="Nebulin 38"
FT REPEAT 1516..1546
FT /note="Nebulin 39"
FT REPEAT 1552..1582
FT /note="Nebulin 40"
FT REPEAT 1590..1620
FT /note="Nebulin 41"
FT REPEAT 1625..1655
FT /note="Nebulin 42"
FT REPEAT 1656..1686
FT /note="Nebulin 43"
FT REPEAT 1692..1722
FT /note="Nebulin 44"
FT REPEAT 1725..1755
FT /note="Nebulin 45"
FT REPEAT 1760..1790
FT /note="Nebulin 46"
FT REPEAT 1796..1826
FT /note="Nebulin 47"
FT REPEAT 1834..1864
FT /note="Nebulin 48"
FT REPEAT 1869..1899
FT /note="Nebulin 49"
FT REPEAT 1900..1930
FT /note="Nebulin 50"
FT REPEAT 1936..1966
FT /note="Nebulin 51"
FT REPEAT 1969..1999
FT /note="Nebulin 52"
FT REPEAT 2004..2034
FT /note="Nebulin 53"
FT REPEAT 2040..2070
FT /note="Nebulin 54"
FT REPEAT 2078..2108
FT /note="Nebulin 55"
FT REPEAT 2113..2143
FT /note="Nebulin 56"
FT REPEAT 2144..2174
FT /note="Nebulin 57"
FT REPEAT 2180..2210
FT /note="Nebulin 58"
FT REPEAT 2213..2243
FT /note="Nebulin 59"
FT REPEAT 2248..2278
FT /note="Nebulin 60"
FT REPEAT 2284..2314
FT /note="Nebulin 61"
FT REPEAT 2322..2352
FT /note="Nebulin 62"
FT REPEAT 2357..2387
FT /note="Nebulin 63"
FT REPEAT 2388..2418
FT /note="Nebulin 64"
FT REPEAT 2423..2453
FT /note="Nebulin 65"
FT REPEAT 2456..2486
FT /note="Nebulin 66"
FT REPEAT 2491..2521
FT /note="Nebulin 67"
FT REPEAT 2527..2557
FT /note="Nebulin 68"
FT REPEAT 2565..2595
FT /note="Nebulin 69"
FT REPEAT 2600..2630
FT /note="Nebulin 70"
FT REPEAT 2631..2661
FT /note="Nebulin 71"
FT REPEAT 2666..2696
FT /note="Nebulin 72"
FT REPEAT 2699..2729
FT /note="Nebulin 73"
FT REPEAT 2734..2764
FT /note="Nebulin 74"
FT REPEAT 2770..2800
FT /note="Nebulin 75"
FT REPEAT 2808..2838
FT /note="Nebulin 76"
FT REPEAT 2843..2873
FT /note="Nebulin 77"
FT REPEAT 2874..2904
FT /note="Nebulin 78"
FT REPEAT 2909..2939
FT /note="Nebulin 79"
FT REPEAT 2942..2972
FT /note="Nebulin 80"
FT REPEAT 2977..3007
FT /note="Nebulin 81"
FT REPEAT 3013..3043
FT /note="Nebulin 82"
FT REPEAT 3051..3081
FT /note="Nebulin 83"
FT REPEAT 3086..3116
FT /note="Nebulin 84"
FT REPEAT 3117..3147
FT /note="Nebulin 85"
FT REPEAT 3152..3182
FT /note="Nebulin 86"
FT REPEAT 3185..3215
FT /note="Nebulin 87"
FT REPEAT 3220..3250
FT /note="Nebulin 88"
FT REPEAT 3256..3286
FT /note="Nebulin 89"
FT REPEAT 3294..3324
FT /note="Nebulin 90"
FT REPEAT 3329..3359
FT /note="Nebulin 91"
FT REPEAT 3360..3390
FT /note="Nebulin 92"
FT REPEAT 3395..3425
FT /note="Nebulin 93"
FT REPEAT 3428..3458
FT /note="Nebulin 94"
FT REPEAT 3463..3493
FT /note="Nebulin 95"
FT REPEAT 3499..3529
FT /note="Nebulin 96"
FT REPEAT 3537..3567
FT /note="Nebulin 97"
FT REPEAT 3572..3602
FT /note="Nebulin 98"
FT REPEAT 3603..3633
FT /note="Nebulin 99"
FT REPEAT 3638..3668
FT /note="Nebulin 100"
FT REPEAT 3671..3701
FT /note="Nebulin 101"
FT REPEAT 3706..3736
FT /note="Nebulin 102"
FT REPEAT 3742..3772
FT /note="Nebulin 103"
FT REPEAT 3780..3810
FT /note="Nebulin 104"
FT REPEAT 3815..3845
FT /note="Nebulin 105"
FT REPEAT 3846..3876
FT /note="Nebulin 106"
FT REPEAT 3914..3944
FT /note="Nebulin 107"
FT REPEAT 3949..3979
FT /note="Nebulin 108"
FT REPEAT 3984..4014
FT /note="Nebulin 109"
FT REPEAT 4021..4052
FT /note="Nebulin 110"
FT REPEAT 4057..4087
FT /note="Nebulin 111"
FT REPEAT 4088..4118
FT /note="Nebulin 112"
FT REPEAT 4123..4153
FT /note="Nebulin 113"
FT REPEAT 4156..4186
FT /note="Nebulin 114"
FT REPEAT 4191..4220
FT /note="Nebulin 115"
FT REPEAT 4226..4256
FT /note="Nebulin 116"
FT REPEAT 4264..4294
FT /note="Nebulin 117"
FT REPEAT 4299..4329
FT /note="Nebulin 118"
FT REPEAT 4330..4360
FT /note="Nebulin 119"
FT REPEAT 4365..4395
FT /note="Nebulin 120"
FT REPEAT 4400..4430
FT /note="Nebulin 121"
FT REPEAT 4435..4465
FT /note="Nebulin 122"
FT REPEAT 4471..4501
FT /note="Nebulin 123"
FT REPEAT 4544..4574
FT /note="Nebulin 124"
FT REPEAT 4575..4605
FT /note="Nebulin 125"
FT REPEAT 4610..4640
FT /note="Nebulin 126"
FT REPEAT 4645..4675
FT /note="Nebulin 127"
FT REPEAT 4680..4710
FT /note="Nebulin 128"
FT REPEAT 4716..4746
FT /note="Nebulin 129"
FT REPEAT 4754..4784
FT /note="Nebulin 130"
FT REPEAT 4789..4819
FT /note="Nebulin 131"
FT REPEAT 4820..4850
FT /note="Nebulin 132"
FT REPEAT 4855..4885
FT /note="Nebulin 133"
FT REPEAT 4890..4920
FT /note="Nebulin 134"
FT REPEAT 4926..4956
FT /note="Nebulin 135"
FT REPEAT 4961..4991
FT /note="Nebulin 136"
FT REPEAT 4997..5027
FT /note="Nebulin 137"
FT REPEAT 5032..5062
FT /note="Nebulin 138"
FT REPEAT 5067..5097
FT /note="Nebulin 139"
FT REPEAT 5137..5167
FT /note="Nebulin 140"
FT REPEAT 5172..5202
FT /note="Nebulin 141"
FT REPEAT 5207..5237
FT /note="Nebulin 142"
FT REPEAT 5242..5272
FT /note="Nebulin 143"
FT REPEAT 5277..5307
FT /note="Nebulin 144"
FT REPEAT 5312..5342
FT /note="Nebulin 145"
FT REPEAT 5347..5377
FT /note="Nebulin 146"
FT REPEAT 5382..5412
FT /note="Nebulin 147"
FT REPEAT 5417..5447
FT /note="Nebulin 148"
FT REPEAT 5452..5482
FT /note="Nebulin 149"
FT REPEAT 5488..5518
FT /note="Nebulin 150"
FT REPEAT 5523..5553
FT /note="Nebulin 151"
FT REPEAT 5558..5588
FT /note="Nebulin 152"
FT REPEAT 5593..5623
FT /note="Nebulin 153"
FT REPEAT 5628..5658
FT /note="Nebulin 154"
FT REPEAT 5665..5695
FT /note="Nebulin 155"
FT REPEAT 5702..5732
FT /note="Nebulin 156"
FT REPEAT 5736..5766
FT /note="Nebulin 157"
FT REPEAT 5771..5801
FT /note="Nebulin 158"
FT REPEAT 5808..5838
FT /note="Nebulin 159"
FT REPEAT 5843..5873
FT /note="Nebulin 160"
FT REPEAT 5878..5908
FT /note="Nebulin 161"
FT REPEAT 5911..5943
FT /note="Nebulin 162"
FT REPEAT 5950..5980
FT /note="Nebulin 163"
FT REPEAT 5987..6017
FT /note="Nebulin 164"
FT REPEAT 6025..6055
FT /note="Nebulin 165"
FT REPEAT 6060..6090
FT /note="Nebulin 166"
FT REPEAT 6095..6125
FT /note="Nebulin 167"
FT REPEAT 6130..6160
FT /note="Nebulin 168"
FT REPEAT 6161..6191
FT /note="Nebulin 169"
FT REPEAT 6192..6222
FT /note="Nebulin 170"
FT REPEAT 6223..6253
FT /note="Nebulin 171"
FT REPEAT 6255..6284
FT /note="Nebulin 172"
FT REPEAT 6285..6315
FT /note="Nebulin 173"
FT REPEAT 6316..6346
FT /note="Nebulin 174"
FT REPEAT 6347..6377
FT /note="Nebulin 175"
FT REPEAT 6378..6408
FT /note="Nebulin 176"
FT REPEAT 6414..6444
FT /note="Nebulin 177"
FT REPEAT 6449..6479
FT /note="Nebulin 178"
FT DOMAIN 6610..6669
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 34..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6457..6612
FT /note="Interaction with SVIL"
FT /evidence="ECO:0000269|PubMed:18639526"
FT REGION 6529..6566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6583..6607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6529..6549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 2959..2960
FT /note="IT -> LN (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:7739042"
FT /id="VSP_054444"
FT VAR_SEQ 2973
FT /note="D -> DKTQIHIMPDTPEIMLARMNKINYSESLYKLANEEAKKKGYDLRSDA
FT IPIVAAKASRDIISDYKYKDGYCKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKD
FT FEKWKTKFSSPVDMLGVVLAKKCQTLVSDVDYKNYLHEWTCLPDQSDVIHARQAYDLQS
FT DNIYKSDLQWLRGIGWVPIGSMDVVKCKRATEILSDNIYRQPPDKLKFTSVTDSLEQVL
FT AKNNALNMNKRLYTEAWDKD (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054445"
FT VAR_SEQ 3854..3859
FT /note="DIIQAK -> DIIQAKKAYDLQSDSVYKADLEWLRGIGWMPEGSVEMNRVKV
FT AQDLVNERLYRTRPEALSFTSIVDTPEVVLAKANSLQISEKLYQEAWNKDKSNITIPSD
FT TPEMLQAHINALQISNKLYQKDWNDAKQKGYDIRADAIEIKHAKASREIASEYKYKEGY
FT RKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKK
FT CQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSV
FT EVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEPLYRDAWEKEKA
FT NVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAIGIQHAKASRDIASD
FT YLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAYNDHKAKISIPVDMV
FT SISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSDSVYKADLEWLRGIG
FT WMPEGSVEMNRVKVAQDLVNERLYRTRPEALSFTSIVDTPEVVLAKANSLQISEKLYQE
FT AWNKDKSNITIPSDTPEMLQAHINALQISNKLYQKDWNDTKQKGYDIRADAIEIKHAKA
FT SREIASEYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIH
FT NTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL
FT EWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQI
FT SEPLYRNAWEKEKANVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAI
FT GIQHAKASRDIASDYLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAY
FT NDHKAKISIPVDMVSISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSD
FT SVYKADLEWLRGIGWMPEGSVEMNRVKVAQDLVNERLYRTRPEALSFTSIVDTPEVVLA
FT KANSLQISEKLYQEAWNKDKSNITIPSDTPEMLQAHINALQISNKLYQKDWNDTKQKGY
FT DIRADAIEIKHAKASREIASEYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD
FT REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKK
FT AYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVD
FT TPEVIQAKINAVQISEPLYRDAWEKEKANVNVPADTPLMLQSKINALQISNKRYQQAWE
FT DVKMTGYDLRADAIGIQHAKASRDIASDYLYKTAYEKQKGHYIGCRSAKEDPKLVWAAN
FT VLKMQNDRLYKKAYNDHKAKISIPVDMVSISAAKEGQALASDVDYRHYLHRWSCFPDQN
FT DVIQAR (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054446"
FT VAR_SEQ 5404..5436
FT /note="KKYRADYEQRKDKYHLVVDEPRHLLAKTAGDQI -> RKYKSSAKMFLQHGC
FT NEILRPDMLTALYNSHMW (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_054447"
FT VAR_SEQ 6272..6273
FT /note="NF -> NFSSILYKENLSKGTPLPVTPEMERVKLNQENFSSVLYKENVGKGI
FT PIPITPEMERVKHNQENFSSVLYKENLGTGIPIPITPEMQRVKHNQENLSSVLYKENMG
FT KGTPLPVTPEMERVKHNQENISSVLYKENMGKGTPLPVTPEMERVKHNQENI (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054448"
FT VARIANT 146
FT /note="T -> A (in dbSNP:rs4077109)"
FT /id="VAR_047692"
FT VARIANT 191
FT /note="E -> Q (in dbSNP:rs35686968)"
FT /id="VAR_047693"
FT VARIANT 974..6669
FT /note="Missing (in AMC6)"
FT /evidence="ECO:0000269|PubMed:26578207"
FT /id="VAR_085714"
FT VARIANT 1027
FT /note="K -> N (in dbSNP:rs6735208)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_047694"
FT VARIANT 1301
FT /note="Y -> H (in dbSNP:rs6711382)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_047695"
FT VARIANT 1469
FT /note="E -> D (in dbSNP:rs34800215)"
FT /id="VAR_047696"
FT VARIANT 1479
FT /note="V -> I (in dbSNP:rs34577613)"
FT /id="VAR_047697"
FT VARIANT 1491
FT /note="V -> M (in dbSNP:rs7426114)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_047698"
FT VARIANT 1969
FT /note="Y -> H (in dbSNP:rs34532796)"
FT /id="VAR_047699"
FT VARIANT 2613
FT /note="K -> N (in dbSNP:rs13013209)"
FT /id="VAR_047700"
FT VARIANT 2773
FT /note="R -> Q (in dbSNP:rs35974308)"
FT /id="VAR_047701"
FT VARIANT 2912
FT /note="S -> P (in dbSNP:rs6713162)"
FT /id="VAR_047702"
FT VARIANT 2952
FT /note="V -> G (in dbSNP:rs13024542)"
FT /id="VAR_047703"
FT VARIANT 3360
FT /note="W -> C (in dbSNP:rs10172023)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_047704"
FT VARIANT 3887
FT /note="S -> T (in dbSNP:rs35227368)"
FT /id="VAR_047705"
FT VARIANT 4271
FT /note="P -> L (in dbSNP:rs4327235)"
FT /id="VAR_047706"
FT VARIANT 4337
FT /note="N -> S (in dbSNP:rs16830236)"
FT /id="VAR_047707"
FT VARIANT 4401
FT /note="R -> T (in dbSNP:rs2288210)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_047708"
FT VARIANT 4561..6669
FT /note="Missing (in AMC6)"
FT /evidence="ECO:0000269|PubMed:29274205"
FT /id="VAR_085715"
FT VARIANT 4626..6669
FT /note="Missing (in AMC6)"
FT /evidence="ECO:0000269|PubMed:29274205"
FT /id="VAR_085716"
FT VARIANT 5030
FT /note="D -> V (in dbSNP:rs2288200)"
FT /id="VAR_024240"
FT VARIANT 5463
FT /note="R -> P (in dbSNP:rs16830171)"
FT /id="VAR_047709"
FT VARIANT 5934
FT /note="G -> E (in dbSNP:rs3732309)"
FT /id="VAR_021888"
FT VARIANT 6131
FT /note="T -> I (in dbSNP:rs34368668)"
FT /id="VAR_056953"
FT VARIANT 6546
FT /note="I -> V (in dbSNP:rs1061305)"
FT /evidence="ECO:0000269|PubMed:7739042"
FT /id="VAR_056954"
FT CONFLICT 727
FT /note="E -> D (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 781
FT /note="K -> R (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 1290
FT /note="N -> S (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 1305
FT /note="A -> R (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 1389
FT /note="S -> T (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 1549
FT /note="A -> R (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 1939
FT /note="P -> L (in Ref. 4; AAA59917)"
FT /evidence="ECO:0000305"
FT CONFLICT 2023
FT /note="M -> I (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 2613
FT /note="K -> Y (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 3796
FT /note="G -> E (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 3838
FT /note="D -> Y (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 5038
FT /note="T -> P (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 5132
FT /note="K -> E (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 5432..5433
FT /note="AG -> RS (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT CONFLICT 6289
FT /note="A -> P (in Ref. 1; CAA58788)"
FT /evidence="ECO:0000305"
FT STRAND 6615..6619
FT /evidence="ECO:0007829|PDB:6Y17"
FT STRAND 6624..6628
FT /evidence="ECO:0007829|PDB:1ARK"
FT STRAND 6636..6652
FT /evidence="ECO:0007829|PDB:6Y17"
FT TURN 6653..6655
FT /evidence="ECO:0007829|PDB:6Y17"
FT STRAND 6658..6662
FT /evidence="ECO:0007829|PDB:6Y17"
FT HELIX 6663..6665
FT /evidence="ECO:0007829|PDB:6Y17"
FT STRAND 6666..6668
FT /evidence="ECO:0007829|PDB:6Y17"
SQ SEQUENCE 6669 AA; 772914 MW; AD93D9B6FB3D8161 CRC64;
MADDEDYEEV VEYYTEEVVY EEVPGETITK IYETTTTRTS DYEQSETSKP ALAQPALAQP
ASAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP
ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV
AYKKGLAEQQ AQFTPLADPP DIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA
RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD
YNVLPASENP QLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK
KYKDSYLKDI LGHYVGSFED PYHSHCMKVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE
AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP
PDTPAFIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD
YEKNKGKMIG VLSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ
LKNFSEARYK DLYVKDVLGH YVGSMEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ
TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDSPVLLQ AQLNTKQLSD LNYKAKHEGE
KFKCHIPADA PQFIQHRVNA YNLSDNVYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS
DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML
QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG
WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK
GEEIIHKYNL PPDLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR
QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKSKYNTP
HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM
KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL
YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW YDLIAKGNNV LGDAIPITAA
KASRNIASDY KYKEAYEKSK GKHVGFRSLQ DDPKLVHYMN VAKLQSDREY KKNYENTKTS
YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDAMS LEHTRNVNQI QSDNVYKDEY
NSFLKGIGWI PIGSLEVEKV KKAGDALNER KYRQHPDTVK FTSVPDSMGM VLAQHNTKQL
SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP
IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF LSLQDDPKLV HYMNVAKIQS DREYKKGYEA
SKTKYHTPLD MVSVTAAKKS QEVATNANYR QSYHHYTLLP DALNVEHSRN AMQIQSDNLY
KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN
KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP
DAIAIKAARA SRDIASDYKY KKAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK
GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNVIHTY NMLPDAMSFE LAKNMMQIQS
DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL
AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY
DLRPDAIPIK AAKASRDIAS DYKYKYNYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR
EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN
RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM
DMVLAKQNAH TMNKHLYTID WNKDKTKIHV MPDTPDILQA KQNQTLYSQK LYKLGWEEAL
KKGYDLPVDA ISVQLAKASR DIASDYKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM
QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA
KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP
DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE
ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKEGFRKQLG HHIGARNIED DPKMMWSMHV
AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV
IHARQAYDLQ SDNLYKSDLQ WLKGIGWMTS GSLEDEKNKR ATQILSDHVY RQHPDQFKFS
SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL
GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IRDDPKMMWS
MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ
SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VSIGSLDVEK CKRATEILSD KIYRQPPDRF
KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR QNKINYSETL
YKLANEEAKK KGYDLRSDAI PIVAAKASRD VISDYKYKDG YRKQLGHHIG ARNIEDDPKM
MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL
PDQNDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSMD VVKCKRAAEI LSDNIYRQPP
DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQV HIMPDTPEIM LARQNKINYS
ESLYRQAMEE AKKEGYDLRS DAIPIVAAKA SRDIASDYKY KEAYRKQLGH HIGARAVHDD
PKIMWSLHIA KVQSDREYKK DFEKYKTRYS SPVDMLGIVL AKKCQTLVSD VDYKHPLHEW
ICLPDQNDII HARKAYDLQS DNLYKSDLEW MKGIGWVPID SLEVVRAKRA GELLSDTIYR
QRPETLKFTS ITDTPEQVLA KNNALNMNKR LYTEAWDNDK KTIHVMPDTP EIMLAKLNRI
NYSDKLYKLA LEESKKEGYD LRLDAIPIQA AKASRDIASD YKYKEGYRKQ LGHHIGARNI
KDDPKMMWSI HVAKIQSDRE YKKEFEKWKT KFSSPVDMLG VVLAKKCQIL VSDIDYKHPL
HEWTCLPDQN DVIQARKAYD LQSDAIYKSD LEWLRGIGWV PIGSVEVEKV KRAGEILSDR
KYRQPADQLK FTCITDTPEI VLAKNNALTM SKHLYTEAWD ADKTSIHVMP DTPDILLAKS
NSANISQKLY TKGWDESKMK DYDLRADAIS IKSAKASRDI ASDYKYKEAY EKQKGHHIGA
QSIEDDPKIM CAIHAGKIQS EREYKKEFQK WKTKFSSPVD MLSILLAKKC QTLVTDIDYR
NYLHEWTCMP DQNDIIQAKK AYDLQSDALY KADLEWLRGI GWMPQGSPEV LRVKNAQNIF
CDSVYRTPVV NLKYTSIVDT PEVVLAKSNA ENISIPKYRE VWDKDKTSIH IMPDTPEINL
ARANALNVSN KLYREGWDEM KAGCDVRLDA IPIQAAKASR EIASDYKYKL DHEKQKGHYV
GTLTARDDNK IRWALIADKL QNEREYRLDW AKWKAKIQSP VDMLSILHSK NSQALVSDMD
YRNYLHQWTC MPDQNDVIQA KKAYELQSDN VYKADLEWLR GIGWMPNDSV SVNHAKHAAD
IFSEKKYRTK IETLNFTPVD DRVDYVTAKQ SGEILDDIKY RKDWNATKSK YTLTETPLLH
TAQEAARILD QYLYKEGWER QKATGYILPP DAVPFVHAHH CNDVQSELKY KAEHVKQKGH
YVGVPTMRDD PKLVWFEHAG QIQNERLYKE DYHKTKAKIN IPADMVSVLA AKQGQTLVSD
IDYRNYLHQW MCHPDQNDVI QARKAYDLQS DNVYRADLEW LRGIGWIPLD SVDHVRVTKN
QEMMSQIKYK KNALENYPNF RSVVDPPEIV LAKINSVNQS DVKYKETFNK AKGKYTFSPD
TPHISHSKDM GKLYSTILYK GAWEGTKAYG YTLDERYIPI VGAKHADLVN SELKYKETYE
KQKGHYLAGK VIGEFPGVVH CLDFQKMRSA LNYRKHYEDT KANVHIPNDM MNHVLAKRCQ
YILSDLEYRH YFHQWTSLLE EPNVIRVRNA QEILSDNVYK DDLNWLKGIG CYVWDTPQIL
HAKKSYDLQS QLQYTAAGKE NLQNYNLVTD TPLYVTAVQS GINASEVKYK ENYHQIKDKY
TTVLETVDYD RTRNLKNLYS SNLYKEAWDR VKATSYILPS STLSLTHAKN QKHLASHIKY
REEYEKFKAL YTLPRSVDDD PNTARCLRVG KLNIDRLYRS VYEKNKMKIH IVPDMVEMVT
AKDSQKKVSE IDYRLRLHEW ICHPDLQVND HVRKVTDQIS DIVYKDDLNW LKGIGCYVWD
TPEILHAKHA YDLRDDIKYK AHMLKTRNDY KLVTDTPVYV QAVKSGKQLS DAVYHYDYVH
SVRGKVAPTT KTVDLDRALH AYKLQSSNLY KTSLRTLPTG YRLPGDTPHF KHIKDTRYMS
SYFKYKEAYE HTKAYGYTLG PKDVPFVHVR RVNNVTSERL YRELYHKLKD KIHTTPDTPE
IRQVKKTQEA VSELIYKSDF FKMQGHMISL PYTPQVIHCR YVGDITSDIK YKEDLQVLKG
FGCFLYDTPD MVRSRHLRKL WSNYLYTDKA RKMRDKYKVV LDTPEYRKVQ ELKTHLSELV
YRAAGKKQKS IFTSVPDTPD LLRAKRGQKL QSQYLYVELA TKERPHHHAG NQTTALKHAK
DVKDMVSEKK YKIQYEKMKD KYTPVPDTPI LIRAKRAYWN ASDLRYKETF QKTKGKYHTV
KDALDIVYHR KVTDDISKIK YKENYMSQLG IWRSIPDRPE HFHHRAVTDT VSDVKYKEDL
TWLKGIGCYA YDTPDFTLAE KNKTLYSKYK YKEVFERTKS DFKYVADSPI NRHFKYATQL
MNEKKYRADY EQRKDKYHLV VDEPRHLLAK TAGDQISQIK YRKNYEKSKD KFTSIVDTPE
HLRTTKVNKQ ISDILYKLEY NKAKPRGYTT IHDTPMLLHV RKVKDEVSDL KYKEVYQRNK
SNCTIEPDAV HIKAAKDAYK VNTNLDYKKQ YEANKAHWKW TPDRPDFLQA AKSSLQQSDF
EYKLDREFLK GCKLSVTDDK NTVLALRNTL IESDLKYKEK HVKERGTCHA VPDTPQILLA
KTVSNLVSEN KYKDHVKKHL AQGSYTTLPE TRDTVHVKEV TKHVSDTNYK KKFVKEKGKS
NYSIMLEPPE VKHAMEVAKK QSDVAYRKDA KENLHYTTVA DRPDIKKATQ AAKQASEVEY
RAKHRKEGSH GLSMLGRPDI EMAKKAAKLS SQVKYRENFD KEKGKTPKYN PKDSQLYKVM
KDANNLASEV KYKADLKKLH KPVTDMKESL IMNHVLNTSQ LASSYQYKKK YEKSKGHYHT
IPDNLEQLHL KEATELQSIV KYKEKYEKER GKPMLDFETP TYITAKESQQ MQSGKEYRKD
YEESIKGRNL TGLEVTPALL HVKYATKIAS EKEYRKDLEE SIRGKGLTEM EDTPDMLRAK
NATQILNEKE YKRDLELEVK GRGLNAMANE TPDFMRARNA TDIASQIKYK QSAEMEKANF
TSVVDTPEII HAQQVKNLSS QKKYKEDAEK SMSYYETVLD TPEIQRVREN QKNFSLLQYQ
CDLKNSKGKI TVVQDTPEIL RVKENQKNFS SVLYKEDVSP GTAIGKTPEM MRVKQTQDHI
SSVKYKEAIG QGTPIPDLPE VKRVKETQKH ISSVMYKENL GTGIPTTVTP EIERVKRNQE
NFSSVLYKEN LGKGIPTPIT PEMERVKRNQ ENFSSVLYKE NMGKGTPLAV TPEMERVKHN
QENISSVLYK ENVGKATATP VTPEMQRVKR NQENISSVLY KENLGKATPT PFTPEMERVK
RNQENFSSVL YKENMRKATP TPVTPEMERA KRNQENISSV LYSDSFRKQI QGKAAYVLDT
PEMRRVRETQ RHISTVKYHE DFEKHKGCFT PVVTDPITER VKKNMQDFSD INYRGIQRKV
VEMEQKRNDQ DQETITGLRV WRTNPGSVFD YDPAEDNIQS RSLHMINVQA QRRSREQSRS
ASALSISGGE EKSEHSEAPD HHLSTYSDGG VFAVSTAYKH AKTTELPQQR SSSVATQQTT
VSSIPSHPST AGKIFRAMYD YMAADADEVS FKDGDAIINV QAIDEGWMYG TVQRTGRTGM
LPANYVEAI
