ID   NECT4_XENTR             Reviewed;         532 AA.
AC   Q5FWR8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Nectin-4;
DE   AltName: Full=Nectin cell adhesion molecule 4 {ECO:0000250|UniProtKB:Q96NY8};
DE   AltName: Full=Poliovirus receptor-related protein 4;
DE   Flags: Precursor;
GN   Name=nectin4 {ECO:0000250|UniProtKB:Q96NY8}; Synonyms=pvrl4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nectin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH89234.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC089234; AAH89234.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q5FWR8; -.
DR   SMR; Q5FWR8; -.
DR   InParanoid; Q5FWR8; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR033320; Nectin-4.
DR   PANTHER; PTHR23277:SF11; PTHR23277:SF11; 1.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..532
FT                   /note="Nectin-4"
FT                   /id="PRO_0000297675"
FT   TOPO_DOM        31..344
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        366..532
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..142
FT                   /note="Ig-like V-type"
FT   DOMAIN          146..235
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          244..328
FT                   /note="Ig-like C2-type 2"
FT   REGION          152..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        51..125
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        169..221
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        266..312
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   532 AA;  57567 MW;  92DEF02E685814B9 CRC64;
     MGPLHGALLP PISVTVSLLI LLLCAPGGRC GVVHTEKSMT AVLGTDVTMP CYYQAEAGEK
     VAQVVWLKKG ANGQNMEIAL LNTEYGANIF GAYEGRIKEK APLDPADGGI VLRNAVQPDE
     GTYLCRVNTF PAGNFDAELE LKVLVPPLPT LGPGPPLTEG EGKSLAASCT AEGNPAPTLT
     WETDVEGTNT TQKYEHPRSS SVTSEFYVVP TRRMNGKPLT CVVSHPGFQQ EKRITHVLQV
     RYLAEVSVQG HEDGWFVGKE GATLQCQAGG NPAPKYEWSR LNGSLPAEVR MEGNTLQFLR
     ALGAEDAGEY ACRASNGIGT KSSTAIVSIA EHQATKIDLV SVSLGSVGIL TAVLLVVLVI
     TLLLVNRHHK RQTKQLSEKI EELSTLSREA SRRRLNSTTA STDTRLQLEE AMHLRSGMHC
     DSLRDPSISS MMGEEADRRS YSTLTTLKET ETQTELLSTV PDEEVKEDGE EPEQVEQSLE
     KEPNPTEPDG MVGVANQPFI KQGMAHFYQE NGTLRAKPSA NGIYINGRGH LV