NECT4_XENTR
ID NECT4_XENTR Reviewed; 532 AA.
AC Q5FWR8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Nectin-4;
DE AltName: Full=Nectin cell adhesion molecule 4 {ECO:0000250|UniProtKB:Q96NY8};
DE AltName: Full=Poliovirus receptor-related protein 4;
DE Flags: Precursor;
GN Name=nectin4 {ECO:0000250|UniProtKB:Q96NY8}; Synonyms=pvrl4;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in cell adhesion. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nectin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89234.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC089234; AAH89234.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q5FWR8; -.
DR SMR; Q5FWR8; -.
DR InParanoid; Q5FWR8; -.
DR Proteomes; UP000008143; Genome assembly.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0046718; P:viral entry into host cell; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR033320; Nectin-4.
DR PANTHER; PTHR23277:SF11; PTHR23277:SF11; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..532
FT /note="Nectin-4"
FT /id="PRO_0000297675"
FT TOPO_DOM 31..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..142
FT /note="Ig-like V-type"
FT DOMAIN 146..235
FT /note="Ig-like C2-type 1"
FT DOMAIN 244..328
FT /note="Ig-like C2-type 2"
FT REGION 152..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 51..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 169..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 266..312
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 532 AA; 57567 MW; 92DEF02E685814B9 CRC64;
MGPLHGALLP PISVTVSLLI LLLCAPGGRC GVVHTEKSMT AVLGTDVTMP CYYQAEAGEK
VAQVVWLKKG ANGQNMEIAL LNTEYGANIF GAYEGRIKEK APLDPADGGI VLRNAVQPDE
GTYLCRVNTF PAGNFDAELE LKVLVPPLPT LGPGPPLTEG EGKSLAASCT AEGNPAPTLT
WETDVEGTNT TQKYEHPRSS SVTSEFYVVP TRRMNGKPLT CVVSHPGFQQ EKRITHVLQV
RYLAEVSVQG HEDGWFVGKE GATLQCQAGG NPAPKYEWSR LNGSLPAEVR MEGNTLQFLR
ALGAEDAGEY ACRASNGIGT KSSTAIVSIA EHQATKIDLV SVSLGSVGIL TAVLLVVLVI
TLLLVNRHHK RQTKQLSEKI EELSTLSREA SRRRLNSTTA STDTRLQLEE AMHLRSGMHC
DSLRDPSISS MMGEEADRRS YSTLTTLKET ETQTELLSTV PDEEVKEDGE EPEQVEQSLE
KEPNPTEPDG MVGVANQPFI KQGMAHFYQE NGTLRAKPSA NGIYINGRGH LV