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NELFD_PIG
ID   NELFD_PIG               Reviewed;         590 AA.
AC   A5GFY4; A5GFY3;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Negative elongation factor D;
DE            Short=NELF-D;
DE   AltName: Full=TH1-like protein;
GN   Name=NELFCD; Synonyms=NELFD, TH1L;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the NELF complex, a complex that
CC       negatively regulates the elongation of transcription by RNA polymerase
CC       II (By similarity). The NELF complex, which acts via an association
CC       with the DSIF complex and causes transcriptional pausing, is
CC       counteracted by the P-TEFb kinase complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q8IXH7}.
CC   -!- SUBUNIT: The NELF complex is composed of NELFA, NELFB, NELFCD and
CC       NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily
CC       through NELFCD to the N-terminus of NELFB (By similarity). Binds RNA
CC       which may help to stabilize the NELF complex on nucleic acid (By
CC       similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and
CC       ssRNA in a sequence- and structure-dependent manner (By similarity).
CC       Interacts with ARAF1 (By similarity). Interacts with PCF11 (By
CC       similarity). Interacts with NELFB (By similarity). Interacts with KAT8
CC       (By similarity). {ECO:0000250|UniProtKB:Q8IXH7,
CC       ECO:0000250|UniProtKB:Q922L6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IXH7}.
CC   -!- SIMILARITY: Belongs to the NELF-D family. {ECO:0000305}.
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DR   EMBL; CR956646; CAN13211.1; -; Genomic_DNA.
DR   EMBL; CR956646; CAN13212.1; -; Genomic_DNA.
DR   RefSeq; NP_001107170.1; NM_001113698.1.
DR   RefSeq; XP_005673120.1; XM_005673063.2.
DR   AlphaFoldDB; A5GFY4; -.
DR   SMR; A5GFY4; -.
DR   STRING; 9823.ENSSSCP00000008029; -.
DR   PaxDb; A5GFY4; -.
DR   PeptideAtlas; A5GFY4; -.
DR   PRIDE; A5GFY4; -.
DR   Ensembl; ENSSSCT00060053771; ENSSSCP00060022918; ENSSSCG00060039723.
DR   Ensembl; ENSSSCT00060053840; ENSSSCP00060022956; ENSSSCG00060039723.
DR   GeneID; 100134985; -.
DR   KEGG; ssc:100134985; -.
DR   CTD; 51497; -.
DR   eggNOG; ENOG502QPUE; Eukaryota.
DR   HOGENOM; CLU_028060_0_0_1; -.
DR   InParanoid; A5GFY4; -.
DR   OrthoDB; 1288184at2759; -.
DR   TreeFam; TF324118; -.
DR   Reactome; R-SSC-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-SSC-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-SSC-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-SSC-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-SSC-75955; RNA Polymerase II Transcription Elongation.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; A5GFY4; SS.
DR   GO; GO:0032021; C:NELF complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   InterPro; IPR006942; TH1.
DR   PANTHER; PTHR12144; PTHR12144; 1.
DR   Pfam; PF04858; TH1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repressor; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..590
FT                   /note="Negative elongation factor D"
FT                   /id="PRO_0000312639"
FT   REGION          15..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..41
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        28
FT                   /note="G -> GQ (in Ref. 1; CAN13211)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   590 AA;  66218 MW;  9CDA21F259C0EC65 CRC64;
     MAGAAPGAIM DEDYFGSAAE WGDEADGGQQ EDDYGEGEDD AEVQQECLHK FSTRDYIMEP
     SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK
     SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS
     DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKHLPEFAKM VCHGEHTYLF
     AQAMMSVLAQ EEQGGSAVRR VAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML
     SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL
     AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF
     PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE
     HSQLDVMEQL ELKKTLLDRM VHLLSRGHVL PVVSYIRKCL EKLDTDISLI RHFVTEVLDV
     IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFILVN
 
 
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