NELL2_DANRE
ID NELL2_DANRE Reviewed; 811 AA.
AC A1A5Y0;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Protein kinase C-binding protein NELL2;
DE AltName: Full=NEL-like protein 2;
DE Flags: Precursor;
GN Name=nell2; ORFNames=zgc:158375;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; BC128854; AAI28855.1; -; mRNA.
DR RefSeq; NP_001073544.1; NM_001080075.1.
DR AlphaFoldDB; A1A5Y0; -.
DR SMR; A1A5Y0; -.
DR STRING; 7955.ENSDARP00000107571; -.
DR PaxDb; A1A5Y0; -.
DR PRIDE; A1A5Y0; -.
DR GeneID; 790930; -.
DR KEGG; dre:790930; -.
DR CTD; 790930; -.
DR ZFIN; ZDB-GENE-030131-7972; nell2a.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A1A5Y0; -.
DR OrthoDB; 767046at2759; -.
DR PhylomeDB; A1A5Y0; -.
DR PRO; PR:A1A5Y0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR CDD; cd00110; LamG; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001007; VWF_dom.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..811
FT /note="Protein kinase C-binding protein NELL2"
FT /id="PRO_0000354683"
FT DOMAIN 54..225
FT /note="Laminin G-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 269..328
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 395..437
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 438..479
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 480..520
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 521..551
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 553..592
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 600..635
FT /note="EGF-like 6; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 636..691
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 696..754
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 613
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 633
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 399..411
FT /evidence="ECO:0000250"
FT DISULFID 405..420
FT /evidence="ECO:0000250"
FT DISULFID 422..436
FT /evidence="ECO:0000250"
FT DISULFID 442..455
FT /evidence="ECO:0000250"
FT DISULFID 449..464
FT /evidence="ECO:0000250"
FT DISULFID 466..478
FT /evidence="ECO:0000250"
FT DISULFID 484..497
FT /evidence="ECO:0000250"
FT DISULFID 491..506
FT /evidence="ECO:0000250"
FT DISULFID 508..519
FT /evidence="ECO:0000250"
FT DISULFID 523..533
FT /evidence="ECO:0000250"
FT DISULFID 527..539
FT /evidence="ECO:0000250"
FT DISULFID 541..550
FT /evidence="ECO:0000250"
FT DISULFID 557..570
FT /evidence="ECO:0000250"
FT DISULFID 564..579
FT /evidence="ECO:0000250"
FT DISULFID 604..617
FT /evidence="ECO:0000250"
FT DISULFID 611..626
FT /evidence="ECO:0000250"
FT DISULFID 628..634
FT /evidence="ECO:0000250"
SQ SEQUENCE 811 AA; 89142 MW; 9D588B3B1574CEC7 CRC64;
MAFLQLFVGL LCGAAVSAFG VDPAVRIGVF QEFSPGQGFS GVTQVKGFRD DTRAFMFQGS
SRSVRVPDAA AGHMLQKLRG KTEFSIALTL KQDKLNSGVI LSIHHGEHRL LELESSGQKS
EVRLHFRTGL QQTHTEIFPF TLADEQWHRV SVSISAAHLT LYVDCNRIYE RVVPVPLMEI
PEDSSFWVGQ RNSAHGLFKG IMQDLQILVM PQGFITQCPD LNRTCPTCND FHGLVQKIME
LQDILAKTSS KLSLAEEKMS GLDSCYCERT CRVKDQIYRE EQSWTDGCKN CTCSNGTVRC
EKILCPPLDC PDGTTPAYVT GTCCKECQPM CLFSEQTLVE GQSCAVHHPS GLCQLFQCRD
RTMHRVPGAE DCPALSCAES DQITLTDRCC RVCRGHDFCA EENICSENSD CVNLDAGASC
GCKNGFRPLR LDSAYCEDID ECAEGRHYCR ENTECVNTAG SFMCVCHTGF IRIDDYSCTE
HDECASGQHD CDENALCFNT VGGHSCSCKP GYSGNGTVCR ALCDGRCLNG GSCASPNVCV
CVQGFSGQNC ETDIDECSEG LVQCAAHATC VNLPGWYHCE CRDGYHDNEV FSANGESCRD
IDECRTGRST CANDTVCFNL DGGFDCRCPH GHNCSGDCIH NSRVRHNAQI WVLDTDHCSV
CSCQEGQVKC RRMVCDCENP TVDVLCCPEC DPRLTSQCLH QNGLLTYSSG DTWIDSCQRC
QCLQGEVDCW PLSCPPVDCD FTLVPEGECC PRCVSDPCQA HAVRSDISKT CIDEHGITRF
SGSAWVKHGT HCTLCQCKNG HVCCSVDPMC L
