NELL2_PONAB
ID NELL2_PONAB Reviewed; 816 AA.
AC Q5R3Z7; Q5R9X4; Q5RC76;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Protein kinase C-binding protein NELL2;
DE AltName: Full=NEL-like protein 2;
DE Flags: Precursor;
GN Name=NELL2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homotrimer. Binds to PKC beta-1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5R3Z7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5R3Z7-2; Sequence=VSP_035803;
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DR EMBL; CR858404; CAH90631.1; -; mRNA.
DR EMBL; CR859256; CAH91436.1; -; mRNA.
DR EMBL; CR861463; CAH93519.1; -; mRNA.
DR RefSeq; NP_001125844.1; NM_001132372.1.
DR RefSeq; NP_001128913.1; NM_001135441.1.
DR AlphaFoldDB; Q5R3Z7; -.
DR SMR; Q5R3Z7; -.
DR STRING; 9601.ENSPPYP00000005057; -.
DR PRIDE; Q5R3Z7; -.
DR Ensembl; ENSPPYT00000005255; ENSPPYP00000005057; ENSPPYG00000004430. [Q5R3Z7-1]
DR Ensembl; ENSPPYT00000057282; ENSPPYP00000044211; ENSPPYG00000004430. [Q5R3Z7-2]
DR GeneID; 100172773; -.
DR GeneID; 100189859; -.
DR KEGG; pon:100189859; -.
DR CTD; 4753; -.
DR GeneTree; ENSGT00810000125439; -.
DR InParanoid; Q5R3Z7; -.
DR OrthoDB; 767046at2759; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR CDD; cd00110; LamG; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001007; VWF_dom.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; EGF-like domain;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..816
FT /note="Protein kinase C-binding protein NELL2"
FT /id="PRO_0000354682"
FT DOMAIN 64..228
FT /note="Laminin G-like"
FT DOMAIN 272..331
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 397..439
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 440..481
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 482..522
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 523..553
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 555..601
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 602..637
FT /note="EGF-like 6; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 638..693
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 698..756
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 225
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 615
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 635
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 401..413
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 407..422
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 424..438
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 444..457
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 451..466
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 468..480
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 486..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 493..508
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 510..521
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 525..535
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 529..541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 543..552
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 559..572
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 566..581
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 583..600
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 606..619
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 613..628
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 630..636
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 3..18
FT /note="SRVLLRTFCLIFGLGA -> TGLGAPLFKAWLLIS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035803"
FT CONFLICT 137
FT /note="H -> R (in Ref. 1; CAH91436)"
FT /evidence="ECO:0000305"
FT CONFLICT 456
FT /note="M -> T (in Ref. 1; CAH91436)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="N -> S (in Ref. 1; CAH91436)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="N -> S (in Ref. 1; CAH93519)"
FT /evidence="ECO:0000305"
FT CONFLICT 545
FT /note="Q -> H (in Ref. 1; CAH90631)"
FT /evidence="ECO:0000305"
FT CONFLICT 616
FT /note="D -> G (in Ref. 1; CAH90631)"
FT /evidence="ECO:0000305"
FT CONFLICT 683
FT /note="T -> I (in Ref. 1; CAH90631)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 816 AA; 91304 MW; FD61E3C23C99750A CRC64;
MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF
QDTPRSVKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG
HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS
TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK
IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT
IQCETLICPN PDCPLNSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE
CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SVCRNLNDRA
VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC
TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV
CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC
SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ
QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV
RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL
