ID   NEMP2_CHICK             Reviewed;         447 AA.
AC   Q5ZJY9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Nuclear envelope integral membrane protein 2;
DE   Flags: Precursor;
GN   Name=NEMP2; Synonyms=TMEM194B; ORFNames=RCJMB04_14f14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein
CC       {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}.
CC   -!- SIMILARITY: Belongs to the NEMP family. {ECO:0000305}.
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DR   EMBL; AJ720295; CAG31954.1; -; mRNA.
DR   RefSeq; NP_001026413.1; NM_001031242.1.
DR   AlphaFoldDB; Q5ZJY9; -.
DR   STRING; 9031.ENSGALP00000003553; -.
DR   PaxDb; Q5ZJY9; -.
DR   GeneID; 423977; -.
DR   KEGG; gga:423977; -.
DR   CTD; 100131211; -.
DR   VEuPathDB; HostDB:geneid_423977; -.
DR   eggNOG; KOG3817; Eukaryota.
DR   InParanoid; Q5ZJY9; -.
DR   OrthoDB; 536946at2759; -.
DR   PhylomeDB; Q5ZJY9; -.
DR   PRO; PR:Q5ZJY9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019358; NEMP_fam.
DR   PANTHER; PTHR13598; PTHR13598; 1.
DR   Pfam; PF10225; NEMP; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..447
FT                   /note="Nuclear envelope integral membrane protein 2"
FT                   /id="PRO_0000332240"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          410..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  51016 MW;  C0B471CE4677A55C CRC64;
     MGPRRLPWAR PGPALGLLLL ALAGAVPAAG GSCSLLEEGN TIQKLHEDCF CYVQNRTMHL
     QYIWSTVQVK INSTRTFRFV PTPEKSNCRN SETVFEFAAC AVQILWRPET STETFLKIKQ
     YGEDFCFRIQ PFKEELYTVS MTREMLDGKL LFLFAAGIFL FHFANSLSRS TNFFYLSGII
     LGVLALLVFV LLALKRFIPR RSTFWILLSG CWMSSLYLIY CFKENMQWLW SEHRIYVLGY
     FVAVGTLSFA TCYQHGPLTS ELSITLFTWT LQLTAFVFIY CGVNIPQVAY AIIAVKPSPK
     GLGYPPAAAW HIGRKMKNHF QSKKVVVRCL TEEEYREQGE TETVRALEEL RSFCKNPDFS
     SWLAVSKLQS PHRFAGFVLG SPHVSPAETK AHDEEYGIGS SFLEEQLFET RTESEQDETT
     SYIHEGDDEN EDEIHEPISF PYATELL