NEMP2_HUMAN
ID NEMP2_HUMAN Reviewed; 417 AA.
AC A6NFY4; B4DYG6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Nuclear envelope integral membrane protein 2;
DE Flags: Precursor;
GN Name=NEMP2; Synonyms=TMEM194B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein
CC {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NFY4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NFY4-2; Sequence=VSP_056847, VSP_056848, VSP_056849;
CC -!- SIMILARITY: Belongs to the NEMP family. {ECO:0000305}.
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DR EMBL; AK302425; BAG63728.1; -; mRNA.
DR EMBL; AC093388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46476.1; -. [A6NFY4-1]
DR RefSeq; NP_001136117.1; NM_001142645.1. [A6NFY4-1]
DR AlphaFoldDB; A6NFY4; -.
DR BioGRID; 756056; 4.
DR IntAct; A6NFY4; 2.
DR STRING; 9606.ENSP00000386292; -.
DR iPTMnet; A6NFY4; -.
DR PhosphoSitePlus; A6NFY4; -.
DR BioMuta; NEMP2; -.
DR EPD; A6NFY4; -.
DR MassIVE; A6NFY4; -.
DR PaxDb; A6NFY4; -.
DR PeptideAtlas; A6NFY4; -.
DR PRIDE; A6NFY4; -.
DR ProteomicsDB; 1089; -. [A6NFY4-1]
DR Antibodypedia; 77970; 4 antibodies from 4 providers.
DR DNASU; 100131211; -.
DR Ensembl; ENST00000409150.8; ENSP00000386292.3; ENSG00000189362.12. [A6NFY4-1]
DR Ensembl; ENST00000414176.5; ENSP00000404283.1; ENSG00000189362.12. [A6NFY4-2]
DR GeneID; 100131211; -.
DR KEGG; hsa:100131211; -.
DR MANE-Select; ENST00000409150.8; ENSP00000386292.3; NM_001142645.2; NP_001136117.1.
DR UCSC; uc010zgf.3; human. [A6NFY4-1]
DR CTD; 100131211; -.
DR DisGeNET; 100131211; -.
DR GeneCards; NEMP2; -.
DR HGNC; HGNC:33700; NEMP2.
DR HPA; ENSG00000189362; Low tissue specificity.
DR MIM; 616497; gene.
DR neXtProt; NX_A6NFY4; -.
DR OpenTargets; ENSG00000189362; -.
DR PharmGKB; PA162406311; -.
DR VEuPathDB; HostDB:ENSG00000189362; -.
DR eggNOG; KOG3817; Eukaryota.
DR GeneTree; ENSGT00390000002174; -.
DR HOGENOM; CLU_025225_0_0_1; -.
DR InParanoid; A6NFY4; -.
DR OMA; RYIPKYS; -.
DR OrthoDB; 536946at2759; -.
DR PhylomeDB; A6NFY4; -.
DR TreeFam; TF314831; -.
DR PathwayCommons; A6NFY4; -.
DR SignaLink; A6NFY4; -.
DR BioGRID-ORCS; 100131211; 13 hits in 1076 CRISPR screens.
DR ChiTaRS; NEMP2; human.
DR GenomeRNAi; 100131211; -.
DR Pharos; A6NFY4; Tdark.
DR PRO; PR:A6NFY4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NFY4; protein.
DR Bgee; ENSG00000189362; Expressed in tendon of biceps brachii and 117 other tissues.
DR ExpressionAtlas; A6NFY4; baseline and differential.
DR Genevisible; A6NFY4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598; PTHR13598; 1.
DR Pfam; PF10225; NEMP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Nucleus; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..417
FT /note="Nuclear envelope integral membrane protein 2"
FT /id="PRO_0000332238"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056847"
FT VAR_SEQ 205..207
FT /note="YST -> AMS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056848"
FT VAR_SEQ 208..417
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056849"
SQ SEQUENCE 417 AA; 48664 MW; 51B1CAC1FEB992FF CRC64;
MGPRQGRWWL LLWLPPLATL PVRGEAAAAA LSVRRCKALK EKDLIRTSES DCYCYNQNSQ
VEWKYIWSTM QVKITSPGLF RIVYIAERHN CQYPENILSF IKCVIHNFWI PKESNEITII
INPYRETVCF SVEPVKKIFN YMIHVNRNIM DFKLFLVFVA GVFLFFYART LSQSPTFYYS
SGTVLGVLMT LVFVLLLVKR FIPKYSTFWA LMVGCWFASV YIVCQLMEDL KWLWYENRIY
VLGYVLIVGF FSFVVCYKHG PLADDRSRSL LMWMLRLLSL VLVYAGVAVP QFAYAAIILL
MSSWSLHYPL RACSYMRWKM EQWFTSKELV VKYLTEDEYR EQADAETNSA LEELRRACRK
PDFPSWLVVS RLHTPSKFAD FVLGGSHLSP EEISLHEEQY GLGGAFLEEQ LFNPSTA
