ID   NEMR_ECOL6              Reviewed;         199 AA.
AC   P67431; P76189;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=HTH-type transcriptional repressor NemR {ECO:0000250|UniProtKB:P67430};
GN   Name=nemR; OrderedLocusNames=c2042;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in response to both electrophiles and reactive
CC       chlorine species (RCS). Represses the transcription of the nemRA-gloA
CC       operon by binding to the NemR box. {ECO:0000250|UniProtKB:P67430}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000250|UniProtKB:P67430}.
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DR   EMBL; AE014075; AAN80502.1; -; Genomic_DNA.
DR   RefSeq; WP_001032936.1; NC_004431.1.
DR   AlphaFoldDB; P67431; -.
DR   SMR; P67431; -.
DR   STRING; 199310.c2042; -.
DR   EnsemblBacteria; AAN80502; AAN80502; c2042.
DR   GeneID; 66674459; -.
DR   KEGG; ecc:c2042; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_28_1_6; -.
DR   OMA; CAQTIYT; -.
DR   BioCyc; ECOL199310:C2042-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR011075; TetR_C.
DR   Pfam; PF16925; TetR_C_13; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..199
FT                   /note="HTH-type transcriptional repressor NemR"
FT                   /id="PRO_0000070640"
FT   DOMAIN          7..67
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        30..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   199 AA;  22275 MW;  E01FDD7D575A1E09 CRC64;
     MNKHTEHDTR EHLLATGEQL CLQRGFTGMG LSELLKTAEV PKGSFYHYFR SKEAFGVAML
     ERHYAAYHQR LTELLQSGEG NYRDRILAYY QQTLNQFCQH GTISGCLTVK LSAEVCDLSE
     DMRSAMDKGA RGVIALLSQA LENGRENHCL TFCGEPLQQA QVLYALWLGA NLQAKISRSF
     EPLENALAHV KNIIATPAV