NEMS_DELRA
ID NEMS_DELRA Reviewed; 10 AA.
AC B3EWL9; B3EWM0;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 02-JUN-2021, entry version 9.
DE RecName: Full=Myosuppressin {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
DE Short=MS {ECO:0000303|PubMed:22848525};
DE Contains:
DE RecName: Full=Myosuppressin(2-10) {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
DE Short=MS(2-10) {ECO:0000303|PubMed:22848525};
OS Delia radicum (Cabbage root fly) (Anthomyia brassicae).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Anthomyiidae; Anthomyiinae; Delia.
OX NCBI_TaxID=30064;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT
RP PHE-10.
RC TISSUE=Abdominal ganglion {ECO:0000269|PubMed:20869420},
RC Brain {ECO:0000269|PubMed:20869420},
RC Corpora allata {ECO:0000269|PubMed:20869420}, and
RC Corpora cardiaca {ECO:0000269|PubMed:20869420};
RX PubMed=20869420; DOI=10.1016/j.peptides.2010.08.028;
RA Audsley N., Matthews H.J., Down R.E., Weaver R.J.;
RT "Neuropeptides associated with the central nervous system of the cabbage
RT root fly, Delia radicum (L).";
RL Peptides 32:434-440(2011).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP SPECTROMETRY, AND AMIDATION AT PHE-10.
RC TISSUE=CNS {ECO:0000269|PubMed:22848525}, and
RC Ring ganglion {ECO:0000269|PubMed:22848525};
RX PubMed=22848525; DOI=10.1371/journal.pone.0041543;
RA Zoephel J., Reiher W., Rexer K.-H., Kahnt J., Wegener C.;
RT "Peptidomics of the agriculturally damaging larval stage of the cabbage
RT root fly Delia radicum (Diptera: Anthomyiidae).";
RL PLoS ONE 7:E41543-E41543(2012).
CC -!- FUNCTION: Myoinhibiting neuropeptide. {ECO:0000250|UniProtKB:P61849}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61849}.
CC -!- TISSUE SPECIFICITY: In larvae, both myosuppressin and myosuppressin(2-
CC 10) are expressed in the CNS but not the midgut, thoracic
CC perisympathetic organs (tPSO) and abdominal perisympathetic organs
CC (aPSO). Myosuppressin is expressed in the ring gland (at protein
CC level). In adults, myosuppressin is expressed in brain, cardiaca,
CC corpora allata and thoracic-abdominal ganglion (at protein level).
CC {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC -!- DEVELOPMENTAL STAGE: Detected in larvae and adults.
CC {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC -!- MASS SPECTROMETRY: [Myosuppressin]: Mass=1247.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC -!- MASS SPECTROMETRY: [Myosuppressin]: Mass=1247.7; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC -!- MASS SPECTROMETRY: [Myosuppressin(2-10)]: Mass=1146.59; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:22848525};
CC -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..10
FT /note="Myosuppressin"
FT /evidence="ECO:0000269|PubMed:20869420,
FT ECO:0000269|PubMed:22848525"
FT /id="PRO_0000419728"
FT PEPTIDE 2..10
FT /note="Myosuppressin(2-10)"
FT /evidence="ECO:0000269|PubMed:20869420,
FT ECO:0000269|PubMed:22848525"
FT /id="PRO_0000419729"
FT MOD_RES 10
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:20869420,
FT ECO:0000269|PubMed:22848525"
SQ SEQUENCE 10 AA; 1248 MW; D3C00329D2C1EAB2 CRC64;
TDVDHVFLRF
