NEMS_DROME
ID NEMS_DROME Reviewed; 100 AA.
AC P61849; P41494; Q9VC91;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Dromyosuppressin {ECO:0000303|PubMed:12171930};
DE AltName: Full=TDVDHVFLRFamide {ECO:0000303|PubMed:1390001};
DE Flags: Precursor;
GN Name=Ms {ECO:0000312|FlyBase:FBgn0011581};
GN ORFNames=CG6440 {ECO:0000312|FlyBase:FBgn0011581};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PROTEIN SEQUENCE OF 87-96.
RX PubMed=1390001; DOI=10.1007/bf03380141;
RA Nichols R.;
RT "Isolation and structural characterization of Drosophila TDVDHVFLRFamide
RT and FMRFamide-containing neural peptides.";
RL J. Mol. Neurosci. 3:213-218(1992).
RN [5]
RP PROTEIN SEQUENCE OF 87-96, AND AMIDATION AT PHE-96.
RC TISSUE=Larva;
RX PubMed=12171930; DOI=10.1074/jbc.m206257200;
RA Baggerman G., Cerstiaens A., De Loof A., Schoofs L.;
RT "Peptidomics of the larval Drosophila melanogaster central nervous
RT system.";
RL J. Biol. Chem. 277:40368-40374(2002).
CC -!- FUNCTION: Myoinhibiting neuropeptide.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000305}.
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DR EMBL; AE014297; AAF56283.1; -; Genomic_DNA.
DR EMBL; AY075325; AAL68192.1; -; mRNA.
DR RefSeq; NP_001262911.1; NM_001275982.1.
DR RefSeq; NP_001287503.1; NM_001300574.1.
DR RefSeq; NP_536772.1; NM_080511.3.
DR AlphaFoldDB; P61849; -.
DR STRING; 7227.FBpp0083991; -.
DR PaxDb; P61849; -.
DR PRIDE; P61849; -.
DR DNASU; 44324; -.
DR EnsemblMetazoa; FBtr0084607; FBpp0083991; FBgn0011581.
DR EnsemblMetazoa; FBtr0334600; FBpp0306667; FBgn0011581.
DR EnsemblMetazoa; FBtr0346341; FBpp0312058; FBgn0011581.
DR GeneID; 44324; -.
DR KEGG; dme:Dmel_CG6440; -.
DR UCSC; CG6440-RA; d. melanogaster.
DR CTD; 4397; -.
DR FlyBase; FBgn0011581; Ms.
DR VEuPathDB; VectorBase:FBgn0011581; -.
DR eggNOG; ENOG502SDA3; Eukaryota.
DR GeneTree; ENSGT00940000176671; -.
DR HOGENOM; CLU_177213_0_0_1; -.
DR InParanoid; P61849; -.
DR OMA; HIKKVCM; -.
DR OrthoDB; 1636503at2759; -.
DR PhylomeDB; P61849; -.
DR BioGRID-ORCS; 44324; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 44324; -.
DR PRO; PR:P61849; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011581; Expressed in head capsule and 17 other tissues.
DR ExpressionAtlas; P61849; baseline and differential.
DR Genevisible; P61849; DM.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:FlyBase.
DR GO; GO:0071855; F:neuropeptide receptor binding; IPI:FlyBase.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
DR GO; GO:0060457; P:negative regulation of digestive system process; IDA:FlyBase.
DR GO; GO:0045822; P:negative regulation of heart contraction; IDA:FlyBase.
DR GO; GO:0010459; P:negative regulation of heart rate; IDA:FlyBase.
DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:FlyBase.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..84
FT /id="PRO_0000021797"
FT PEPTIDE 87..96
FT /note="Dromyosuppressin"
FT /id="PRO_0000021798"
FT MOD_RES 96
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:12171930"
SQ SEQUENCE 100 AA; 11070 MW; 177CBFA528D8BE58 CRC64;
MSFAQFFVAC CLAIVLLAVS NTRAAVQGPP LCQSGIVEEM PPHIRKVCQA LENSDQLTSA
LKSYINNEAS ALVANSDDLL KNYNKRTDVD HVFLRFGKRR
