ID   NEMS_RHOPR              Reviewed;          10 AA.
AC   P85816;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   11-DEC-2019, entry version 14.
DE   RecName: Full=Myosuppressin {ECO:0000303|PubMed:19137558};
DE            Short=Rhopr-MS {ECO:0000303|PubMed:19137558};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1,
RP   OXIDATION AT MET-8, AND AMIDATION AT PHE-10.
RC   TISSUE=Brain {ECO:0000269|PubMed:19137558};
RX   PubMed=19137558; DOI=10.1002/pmic.200800499;
RA   Ons S., Richter F., Urlaub H., Pomar R.R.;
RT   "The neuropeptidome of Rhodnius prolixus brain.";
RL   Proteomics 9:788-792(2009).
CC   -!- FUNCTION: Myoinhibiting neuropeptide. {ECO:0000250|UniProtKB:P61849}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61849}.
CC   -!- PTM: Occurs in three forms: Rhopr-MS has unmodified Gln-1 and Met-8,
CC       Pyro-Rhopr-MS has pyroglutamate at Gln-1 and unmodified Met-8, Pyro-ox-
CC       Rhopr-MS has pyroglutamate at Gln-1 and oxidation at Met-8.
CC       {ECO:0000269|PubMed:19137558}.
CC   -!- MASS SPECTROMETRY: Mass=1306.64; Method=MALDI; Note=With unmodified
CC       Gln-1 and Met-8.; Evidence={ECO:0000269|PubMed:19137558};
CC   -!- MASS SPECTROMETRY: Mass=1289.60; Method=MALDI; Note=With pyroglutamate
CC       at Gln-1 and unmodified Met-8.; Evidence={ECO:0000269|PubMed:19137558};
CC   -!- MASS SPECTROMETRY: Mass=1305.60; Method=MALDI; Note=With pyroglutamate
CC       at Gln-1 and oxidation at Met-8.;
CC       Evidence={ECO:0000269|PubMed:19137558};
CC   -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000255}.
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DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Oxidation;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Myosuppressin"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT                   /id="PRO_0000365767"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid; partial"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT   MOD_RES         8
FT                   /note="Methionine sulfoxide"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT   UNSURE          3
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:19137558"
SQ   SEQUENCE   10 AA;  1307 MW;  51C45399D2C1EAA7 CRC64;
     QDLDHVFMRF