ID   NENF_BOVIN              Reviewed;         169 AA.
AC   Q1JQA5;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Neudesin;
DE   AltName: Full=Neuron-derived neurotrophic factor;
DE   AltName: Full=SCIRP10-related protein;
DE   AltName: Full=Spinal cord injury-related protein 10;
DE   Flags: Precursor;
GN   Name=NENF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons
CC       enhancing neuronal survival (By similarity). Promotes cell
CC       proliferation and neurogenesis in undifferentiated neural progenitor
CC       cells at the embryonic stage and inhibits differentiation of astrocytes
CC       (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2,
CC       MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity
CC       is enhanced by binding to heme (By similarity). Acts also as an
CC       anorexigenic neurotrophic factor that contributes to energy balance (By
CC       similarity). {ECO:0000250|UniProtKB:Q9CQ45}.
CC   -!- SUBUNIT: Interacts with PINK1 and PARK7.
CC       {ECO:0000250|UniProtKB:Q9UMX5}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000250|UniProtKB:Q9CQ45}. Mitochondrion
CC       {ECO:0000250|UniProtKB:Q9UMX5}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9UMX5}. Note=Localized to mitochondria and
CC       endoplasmic reticulum by PINK1 and PARK7.
CC       {ECO:0000250|UniProtKB:Q9UMX5}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residue at position
CC       79. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC       extranuclear signaling are classified in 2 groups: the class II
CC       progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC       PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC       protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC       {ECO:0000250|UniProtKB:Q9UMX5}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC116106; AAI16107.1; -; mRNA.
DR   RefSeq; NP_001069887.1; NM_001076419.1.
DR   AlphaFoldDB; Q1JQA5; -.
DR   SMR; Q1JQA5; -.
DR   STRING; 9913.ENSBTAP00000001007; -.
DR   PaxDb; Q1JQA5; -.
DR   PRIDE; Q1JQA5; -.
DR   Ensembl; ENSBTAT00000001007; ENSBTAP00000001007; ENSBTAG00000000759.
DR   GeneID; 616334; -.
DR   KEGG; bta:616334; -.
DR   CTD; 29937; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000759; -.
DR   VGNC; VGNC:32006; NENF.
DR   eggNOG; KOG1110; Eukaryota.
DR   GeneTree; ENSGT00940000162504; -.
DR   HOGENOM; CLU_134788_0_0_1; -.
DR   InParanoid; Q1JQA5; -.
DR   OMA; FNIRDEF; -.
DR   OrthoDB; 1532459at2759; -.
DR   TreeFam; TF332131; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000000759; Expressed in laryngeal cartilage and 106 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0032099; P:negative regulation of appetite; ISS:UniProtKB.
DR   GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Endoplasmic reticulum; Heme; Iron; Metal-binding;
KW   Mitochondrion; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..169
FT                   /note="Neudesin"
FT                   /id="PRO_0000350625"
FT   DOMAIN          41..126
FT                   /note="Cytochrome b5 heme-binding"
FT   REGION          148..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         133
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UMX5"
SQ   SEQUENCE   169 AA;  18313 MW;  1BB40E1B7DFEFF2F CRC64;
     MAGPAPGRRL VALALIVALA VGLPTAGAGQ APRPAERGPP VRLFTEEELA RYGGEEEDQP
     IYMAVKGVVF DVTSGKEFYG RGAPYNALTG KDSTRGVAKM SLDPADLTHD TTGLTAEELE
     SLDDVFTRVY KAKYPIVGYT ARRILNEDGS PNLDFKPEDQ PHFDIKDEF