NENYA_DROME
ID NENYA_DROME Reviewed; 219 AA.
AC Q8IMM9;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=RING finger protein nenya {ECO:0000303|PubMed:30615609, ECO:0000312|FlyBase:FBgn0051053};
GN Name=nenya {ECO:0000303|PubMed:30615609, ECO:0000312|FlyBase:FBgn0051053};
GN ORFNames=CG31053 {ECO:0000312|FlyBase:FBgn0051053};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ABJ17001.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C.,
RA Celniker S.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=30615609; DOI=10.1371/journal.pgen.1007886;
RA Lake C.M., Nielsen R.J., Bonner A.M., Eche S., White-Brown S., McKim K.S.,
RA Hawley R.S.;
RT "Narya, a RING finger domain-containing protein, is required for meiotic
RT DNA double-strand break formation and crossover maturation in Drosophila
RT melanogaster.";
RL PLoS Genet. 15:E1007886-E1007886(2019).
CC -!- FUNCTION: Required for the formation of DNA double-strand breaks
CC together with narya and vilya during the meiotic recombination process
CC (PubMed:30615609). Plays a redundant role with narya in chromosome
CC segregation during female meiosis (PubMed:30615609).
CC {ECO:0000269|PubMed:30615609}.
CC -!- SUBUNIT: May interact with itself, with narya and vilya through its
CC RING-type zinc finger. {ECO:0000305|PubMed:30615609}.
CC -!- MISCELLANEOUS: Nenya, narya and vilya contain a RING-type zinc finger
CC domain and are named after the Three Rings of Power given by the elves
CC of Eregion in J.R.R. Tolkien's books. {ECO:0000305|PubMed:30615609}.
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DR EMBL; AE014297; AAN14131.1; -; Genomic_DNA.
DR EMBL; BT029068; ABJ17001.1; -; mRNA.
DR RefSeq; NP_733236.1; NM_170357.3.
DR AlphaFoldDB; Q8IMM9; -.
DR IntAct; Q8IMM9; 2.
DR STRING; 7227.FBpp0084637; -.
DR PaxDb; Q8IMM9; -.
DR DNASU; 318572; -.
DR EnsemblMetazoa; FBtr0085268; FBpp0084637; FBgn0051053.
DR GeneID; 318572; -.
DR KEGG; dme:Dmel_CG31053; -.
DR UCSC; CG31053-RA; d. melanogaster.
DR CTD; 318572; -.
DR FlyBase; FBgn0051053; nenya.
DR VEuPathDB; VectorBase:FBgn0051053; -.
DR eggNOG; KOG4739; Eukaryota.
DR GeneTree; ENSGT00740000115581; -.
DR HOGENOM; CLU_1268118_0_0_1; -.
DR InParanoid; Q8IMM9; -.
DR OMA; NCKHILC; -.
DR OrthoDB; 1325661at2759; -.
DR PhylomeDB; Q8IMM9; -.
DR BioGRID-ORCS; 318572; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 318572; -.
DR PRO; PR:Q8IMM9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051053; Expressed in egg cell and 12 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0019789; F:SUMO transferase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISM:FlyBase.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR GO; GO:1903343; P:positive regulation of meiotic DNA double-strand break formation; IGI:UniProtKB.
DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR042123; Zip3/RNF212-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22663; PTHR22663; 1.
DR Pfam; PF14634; zf-RING_5; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Chromosome partition; Meiosis; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..219
FT /note="RING finger protein nenya"
FT /id="PRO_0000447342"
FT ZN_FING 6..48
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 161..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 219 AA; 25980 MW; 152C0E07898E4934 CRC64;
MFRIHCNKCF RRRNVEPTLI FHMTQCQHVL CASCLSESST DKKCPLCKRD LRAIPIDKNL
PPNVAQYFED PLRFQQLYRK ISKFQADQRA SDNLGFYRQM QEHEKNESRL KGFCKMEAQF
NQQIQKEKER IAELRAYIKY HEEEGLKEWP HATGVEKPWS NQARGLRPRT PSVTTSDNTQ
SDEHMTTFCL DSDIDCLEED EPRRYVKKTF NGNIKDFHI
