NEPR1_CAEEL
ID NEPR1_CAEEL Reviewed; 140 AA.
AC Q9XXN3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1 homolog;
DE Short=NEP1-R1;
DE AltName: Full=Transmembrane protein 188;
GN Name=nepr-1 {ECO:0000312|WormBase:T19A6.3a};
GN ORFNames=T19A6.3 {ECO:0000312|WormBase:T19A6.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22134922; DOI=10.1074/jbc.m111.324350;
RA Han S., Bahmanyar S., Zhang P., Grishin N., Oegema K., Crooke R.,
RA Graham M., Reue K., Dixon J.E., Goodman J.M.;
RT "Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is
RT the metazoan SPO7 ortholog and functions in the lipin activation pathway.";
RL J. Biol. Chem. 287:3123-3137(2012).
CC -!- FUNCTION: May form with the serine/threonine protein phosphatase scpl-2
CC an active complex dephosphorylating and activating lipin-like
CC phosphatases. Lipins are phosphatidate phosphatases that catalyze the
CC conversion of phosphatidic acid to diacylglycerol and control the
CC metabolism of fatty acids at different levels. May play a role in
CC nuclear membrane dynamics being crucial for early development of the
CC embryo. {ECO:0000269|PubMed:22134922}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q8N9A8};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N9A8}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8N9A8}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in the formation
CC of two nuclei in each daughter cell following the first embryonic
CC division. {ECO:0000269|PubMed:22134922}.
CC -!- SIMILARITY: Belongs to the CNEP1R1 family. {ECO:0000305}.
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DR EMBL; BX284601; CAA16513.2; -; Genomic_DNA.
DR PIR; T24971; T24971.
DR RefSeq; NP_492277.1; NM_059876.4.
DR AlphaFoldDB; Q9XXN3; -.
DR SMR; Q9XXN3; -.
DR BioGRID; 38058; 1.
DR DIP; DIP-25580N; -.
DR STRING; 6239.T19A6.3b; -.
DR EPD; Q9XXN3; -.
DR PaxDb; Q9XXN3; -.
DR EnsemblMetazoa; T19A6.3a.1; T19A6.3a.1; WBGene00011828.
DR GeneID; 172625; -.
DR UCSC; T19A6.3b; c. elegans.
DR CTD; 172625; -.
DR WormBase; T19A6.3a; CE28962; WBGene00011828; nepr-1.
DR eggNOG; KOG4606; Eukaryota.
DR GeneTree; ENSGT00390000008576; -.
DR HOGENOM; CLU_138149_0_0_1; -.
DR InParanoid; Q9XXN3; -.
DR Reactome; R-CEL-4419969; Depolymerisation of the Nuclear Lamina.
DR PRO; PR:Q9XXN3; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00011828; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q9XXN3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:UniProtKB.
DR GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
DR GO; GO:0051783; P:regulation of nuclear division; IMP:WormBase.
DR InterPro; IPR019168; NEP1-R1.
DR PANTHER; PTHR20996; PTHR20996; 1.
DR Pfam; PF09771; Tmemb_18A; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Lipid metabolism; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..140
FT /note="Nuclear envelope phosphatase-regulatory subunit 1
FT homolog"
FT /id="PRO_0000286621"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 140 AA; 15854 MW; F8B6B984190EB2F1 CRC64;
MAIQARRMPE DPSTACEDLK FFEKRLTEVI TYMGPTCTRW RIAIVIFAVL VGVIGSKYFA
NEKIEIFQIP MIDMFLTTHL DFTLCFFVGL LLFAVFGVHR RIVAPTIVAR RCRDALSPFS
LSCDHNGKLI VKPAVRNSAP
