ID   NEPR1_DANRE             Reviewed;         125 AA.
AC   Q561X0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1;
DE   AltName: Full=Transmembrane protein 188;
GN   Name=cnep1r1; Synonyms=tmem188; ORFNames=zgc:110674;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May form with the serine/threonine protein phosphatase
CC       ctdnep1 an active complex dephosphorylating and activating lipins.
CC       Lipins are phosphatidate phosphatases that catalyze the conversion of
CC       phosphatidic acid to diacylglycerol and control the metabolism of fatty
CC       acids at different levels. May indirectly modulate the lipid
CC       composition of nuclear and/or endoplasmic reticulum membranes and be
CC       required for proper nuclear membrane morphology and/or dynamics. May
CC       also indirectly regulate the production of lipid droplets and
CC       triacylglycerol (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNEP1R1 family. {ECO:0000305}.
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DR   EMBL; BC092973; AAH92973.1; -; mRNA.
DR   RefSeq; NP_001017874.1; NM_001017874.1.
DR   AlphaFoldDB; Q561X0; -.
DR   STRING; 7955.ENSDARP00000052350; -.
DR   PaxDb; Q561X0; -.
DR   Ensembl; ENSDART00000052351; ENSDARP00000052350; ENSDARG00000036064.
DR   GeneID; 550572; -.
DR   KEGG; dre:550572; -.
DR   CTD; 255919; -.
DR   ZFIN; ZDB-GENE-050417-425; cnep1r1.
DR   eggNOG; KOG4606; Eukaryota.
DR   GeneTree; ENSGT00390000008576; -.
DR   HOGENOM; CLU_138149_1_0_1; -.
DR   InParanoid; Q561X0; -.
DR   OMA; DQTVCED; -.
DR   OrthoDB; 1586654at2759; -.
DR   PhylomeDB; Q561X0; -.
DR   TreeFam; TF313179; -.
DR   Reactome; R-DRE-4419969; Depolymerisation of the Nuclear Lamina.
DR   PRO; PR:Q561X0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036064; Expressed in mature ovarian follicle and 21 other tissues.
DR   ExpressionAtlas; Q561X0; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; ISS:UniProtKB.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:UniProtKB.
DR   GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019168; NEP1-R1.
DR   PANTHER; PTHR20996; PTHR20996; 1.
DR   Pfam; PF09771; Tmemb_18A; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipid metabolism; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Nuclear envelope phosphatase-regulatory subunit 1"
FT                   /id="PRO_0000286618"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  14175 MW;  BBC3AC7EEAD1D346 CRC64;
     MNSLEQAEDL KAFERRLTEY VSCLQPATGR WRMILIVVSV CTATGAWNWL IDPDTQKVSF
     FSSLWNHPFF TISCVTLIGL FFAGIHKRVV APSIIAARCR TVLAEYNMSC DDTGKLILKP
     RPHIQ