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NEPR1_DROME
ID   NEPR1_DROME             Reviewed;         131 AA.
AC   Q8T0B1; Q9VTA4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1 homolog;
DE   AltName: Full=Transmembrane protein 188;
GN   ORFNames=CG8009;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA   Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA   Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA   Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA   Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May form with the serine/threonine protein phosphatase
CC       l(1)G0269 an active complex dephosphorylating and activating lipin-like
CC       phosphatases. Lipins are phosphatidate phosphatases that catalyze the
CC       conversion of phosphatidic acid to diacylglycerol and control the
CC       metabolism of fatty acids at different levels (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8T0B1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8T0B1-2; Sequence=VSP_025132;
CC   -!- SIMILARITY: Belongs to the CNEP1R1 family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF50148.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAN11906.1; -; Genomic_DNA.
DR   EMBL; AY069435; AAL39580.1; -; mRNA.
DR   RefSeq; NP_648400.1; NM_140143.3. [Q8T0B1-1]
DR   RefSeq; NP_729617.1; NM_168415.2. [Q8T0B1-2]
DR   AlphaFoldDB; Q8T0B1; -.
DR   SMR; Q8T0B1; -.
DR   IntAct; Q8T0B1; 2.
DR   STRING; 7227.FBpp0075984; -.
DR   GlyGen; Q8T0B1; 2 sites.
DR   PaxDb; Q8T0B1; -.
DR   PRIDE; Q8T0B1; -.
DR   DNASU; 39204; -.
DR   EnsemblMetazoa; FBtr0076254; FBpp0075983; FBgn0036090. [Q8T0B1-2]
DR   EnsemblMetazoa; FBtr0076255; FBpp0075984; FBgn0036090. [Q8T0B1-1]
DR   GeneID; 39204; -.
DR   KEGG; dme:Dmel_CG8009; -.
DR   UCSC; CG8009-RA; d. melanogaster. [Q8T0B1-1]
DR   FlyBase; FBgn0036090; CG8009.
DR   VEuPathDB; VectorBase:FBgn0036090; -.
DR   eggNOG; KOG4606; Eukaryota.
DR   GeneTree; ENSGT00390000008576; -.
DR   InParanoid; Q8T0B1; -.
DR   OMA; DQTVCED; -.
DR   PhylomeDB; Q8T0B1; -.
DR   Reactome; R-DME-4419969; Depolymerisation of the Nuclear Lamina.
DR   BioGRID-ORCS; 39204; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39204; -.
DR   PRO; PR:Q8T0B1; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0036090; Expressed in seminal fluid secreting gland and 34 other tissues.
DR   ExpressionAtlas; Q8T0B1; baseline and differential.
DR   Genevisible; Q8T0B1; DM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:FlyBase.
DR   GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; ISS:UniProtKB.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:UniProtKB.
DR   GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019168; NEP1-R1.
DR   PANTHER; PTHR20996; PTHR20996; 1.
DR   Pfam; PF09771; Tmemb_18A; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Glycoprotein; Lipid metabolism; Membrane;
KW   Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Nuclear envelope phosphatase-regulatory subunit 1
FT                   homolog"
FT                   /id="PRO_0000286622"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         32..36
FT                   /note="KLLAV -> I (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025132"
SQ   SEQUENCE   131 AA;  14877 MW;  C423B313925276D1 CRC64;
     MEPSACEDLK AFERRLTEVV SSYRPSTFRW RKLLAVVLSA MSMCTAISAW YWLRDPRTTV
     VPLTESLWIH PVFTVATLTL VVLFILGIQK LVIAPQIITS RTRMVLGDFN MSCDDTGKLI
     LKPRQSNNNS T
 
 
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