ID   NEPR1_XENTR             Reviewed;         125 AA.
AC   Q5M8F7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1;
DE   AltName: Full=Transmembrane protein 188;
GN   Name=cnep1r1; Synonyms=tmem188; ORFNames=TEgg132c10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May form with the serine/threonine protein phosphatase
CC       ctdnep1 an active complex dephosphorylating and activating lipins.
CC       Lipins are phosphatidate phosphatases that catalyze the conversion of
CC       phosphatidic acid to diacylglycerol and control the metabolism of fatty
CC       acids at different levels. May indirectly modulate the lipid
CC       composition of nuclear and/or endoplasmic reticulum membranes and be
CC       required for proper nuclear membrane morphology and/or dynamics. May
CC       also indirectly regulate the production of lipid droplets and
CC       triacylglycerol (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNEP1R1 family. {ECO:0000305}.
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DR   EMBL; CR760569; CAJ81789.1; -; mRNA.
DR   EMBL; BC088044; AAH88044.1; -; mRNA.
DR   RefSeq; NP_001011315.1; NM_001011315.2.
DR   AlphaFoldDB; Q5M8F7; -.
DR   STRING; 8364.ENSXETP00000051831; -.
DR   PaxDb; Q5M8F7; -.
DR   GeneID; 496772; -.
DR   KEGG; xtr:496772; -.
DR   CTD; 255919; -.
DR   Xenbase; XB-GENE-5917931; cnep1r1.
DR   eggNOG; KOG4606; Eukaryota.
DR   HOGENOM; CLU_138149_1_0_1; -.
DR   InParanoid; Q5M8F7; -.
DR   OMA; KYFANEL; -.
DR   OrthoDB; 1586654at2759; -.
DR   PhylomeDB; Q5M8F7; -.
DR   TreeFam; TF313179; -.
DR   Reactome; R-XTR-4419969; Depolymerisation of the Nuclear Lamina.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071595; C:Nem1-Spo7 phosphatase complex; ISS:UniProtKB.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:UniProtKB.
DR   GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019168; NEP1-R1.
DR   PANTHER; PTHR20996; PTHR20996; 1.
DR   Pfam; PF09771; Tmemb_18A; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipid metabolism; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Nuclear envelope phosphatase-regulatory subunit 1"
FT                   /id="PRO_0000286620"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  14203 MW;  4B842E25D2700340 CRC64;
     MNSLEQAEDL KAFERRLTEY VSCLQPATGR WRMILIVVSV CTATGAWNWL IDPETQKVSF
     FTSLWNHPFF TISCITLIGL FFAGIHKRVV APSIIAARCR TVLAEYNMSC DDTGKLILKP
     RPHVQ