ID   NEPRO_DANRE             Reviewed;         525 AA.
AC   Q567G6; Q5RI41;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Nucleolus and neural progenitor protein {ECO:0000305};
GN   Name=nepro {ECO:0000250|UniProtKB:Q8R2U2};
GN   ORFNames=si:dkey-22a1.3, zgc:112065;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-151.
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May play a role in the Notch signaling pathway.
CC       {ECO:0000250|UniProtKB:Q8R2U2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R2U2}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q8R2U2}.
CC   -!- SIMILARITY: Belongs to the nepro family. {ECO:0000305}.
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DR   EMBL; BC093180; AAH93180.1; -; mRNA.
DR   EMBL; BX322637; CAI20988.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q567G6; -.
DR   STRING; 7955.ENSDARP00000115468; -.
DR   PaxDb; Q567G6; -.
DR   ZFIN; ZDB-GENE-030131-5651; nepro.
DR   eggNOG; ENOG502QTP3; Eukaryota.
DR   InParanoid; Q567G6; -.
DR   PhylomeDB; Q567G6; -.
DR   PRO; PR:Q567G6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR027951; DUF4477.
DR   Pfam; PF14780; DUF4477; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..525
FT                   /note="Nucleolus and neural progenitor protein"
FT                   /id="PRO_0000360409"
FT   REGION          435..453
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R2U2"
FT   CONFLICT        26
FT                   /note="G -> D (in Ref. 2; CAI20988)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        151
FT                   /note="T -> A (in Ref. 2; CAI20988)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   525 AA;  60073 MW;  FF241928BBBC44DF CRC64;
     MAQECWNKIN IPFPSAVSST RIPFTGSIDL LIDCLLADCE KVLTLLCSEV LQTEIRVLYE
     LLYILNNGFR QHKPFRALKQ VEQCVNRLKE MKLQAAVEDL KEVCPNKFQR EAGAEAGECD
     VPSQPMLEWL GLKLLGASSL LARTLERCTK TFLLTRQHLR LGEFIVLNVV ITSMLSRLWV
     FFRGILRALI PMYRRNCELL QKVSQSQPMA YLTDFTLPED LKDFLCLTYP DLKIEEVTKD
     LLKGTRGKRK SKFSLLSKLF GDTEQQEEIG EGERDLMPIL SAGHYEVSSL DLGAAVSQRR
     TDYSDVSPYG LGIKAMLQQS SKTTKQKSLE QQMKLDSSSK ASLCQKRTSL KKTSSFRNMA
     ALLKELMNWC RSCKFYQEHK RLAFLSLKCG RMESLEAEGV RVEKRLKTFK IKVQKALTLQ
     QTFPPKHSCS LPALLRTRWQ NKFFMRHFRT LRRRSAVSRK SSGTVKGSLN QRRKCRPLLQ
     SSNEVESGEN VTASVEIEKM DSQTSLQEPN IPKDDIDDIF ESFGF