NEP_I86A3
ID NEP_I86A3 Reviewed; 112 AA.
AC O09688;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 29-SEP-2021, entry version 75.
DE RecName: Full=Nuclear export protein;
DE Short=NEP;
DE AltName: Full=Non structural protein 2;
DE Short=NS2;
DE Flags: Fragment;
GN Name=NS;
OS Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.
OX NCBI_TaxID=380339;
OH NCBI_TaxID=8782; Aves.
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8892928; DOI=10.1128/jvi.70.11.8041-8046.1996;
RA Guan Y., Shortridge K.F., Krauss S., Li P.H., Kawaoka Y., Webster R.G.;
RT "Emergence of avian H1N1 influenza viruses in pigs in China.";
RL J. Virol. 70:8041-8046(1996).
CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs
CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs
CC complexes and the nuclear export machinery of the cell. Possesses no
CC intrinsic RNA-binding activity, but includes a C-terminal M1-binding
CC domain. This domain is believed to allow recognition of RNPs to which
CC the M1 protein is bound. Because the M1 protein is not available in
CC large quantities until the later stages of infection, such an indirect
CC recognition mechanism probably ensures that genomic RNPs are not
CC exported from the nucleus before sufficient quantities of viral mRNA
CC and progeny genomic RNA have been synthesized. Furthermore, the RNPs
CC enters the cytoplasm only when they have associated with the M1 protein
CC that is necessary to guide them to the plasma membrane. May down-
CC regulate viral RNA synthesis when overproduced (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds M1 protein. May interact with human nucleoporin RAB/HRB
CC and exportin XPO1/CRM1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NEP; Synonyms=NS2;
CC IsoId=O09688-1; Sequence=Displayed;
CC Name=NS1;
CC IsoId=Q9WA92-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. {ECO:0000305}.
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DR EMBL; U49487; AAB51002.1; -; Genomic_RNA.
DR SMR; O09688; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039675; P:exit of virus from host cell nucleus through nuclear pore; IEA:InterPro.
DR InterPro; IPR000968; Flu_NS2.
DR Pfam; PF00601; Flu_NS2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Host nucleus; Host-virus interaction; Transport;
KW Virion.
FT CHAIN 1..112
FT /note="Nuclear export protein"
FT /id="PRO_0000324230"
FT MOTIF 9..18
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT MOTIF 82..91
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 112
SQ SEQUENCE 112 AA; 13348 MW; 7400FF25359DB357 CRC64;
NTVSSFQDIL MRMSKMQLGS SSEDLNGMII RLESLKLYRD SLGEAVMRMG DLHSLQSRNE
KWREQLSQKF EEIRWLIEEV RHRLKNTENS FEQITFMQAL QLLLEVEQEI RT