ID   NEP_ISAV8               Reviewed;         146 AA.
AC   Q8V3U1;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   23-FEB-2022, entry version 38.
DE   RecName: Full=Nuclear export protein;
DE            Short=NEP;
DE   AltName: Full=Protein P5;
DE            Short=P5;
GN   Name=Segment-7 {ECO:0000303|PubMed:20979983}; ORFNames=s7ORF2;
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11807235; DOI=10.1099/0022-1317-83-2-421;
RA   Clouthier S.C., Rector T., Brown N.E., Anderson E.D.;
RT   "Genomic organization of infectious salmon anaemia virus.";
RL   J. Gen. Virol. 83:421-428(2002).
RN   [2]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
RN   [3]
RP   FUNCTION, AND ALTERNATIVE SPLICING.
RX   PubMed=23850870; DOI=10.1016/j.virusres.2013.07.001;
RA   Ramly R.B., Olsen C.M., Braaen S., Rimstad E.;
RT   "Infectious salmon anaemia virus nuclear export protein is encoded by a
RT   spliced gene product of genomic segment 7.";
RL   Virus Res. 177:1-10(2013).
RN   [4]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH HOST HSC70.
RX   PubMed=28202040; DOI=10.1186/s12985-017-0702-z;
RA   Zhang W., Cai C., Lin L., Tao Y.J., Jin M.;
RT   "Subcellular localization and interactions of Infectious Salmon Anemia
RT   Virus (ISAV) M1 and NEP as well as host Hsc70.";
RL   Virol. J. 14:30-30(2017).
CC   -!- FUNCTION: May mediate the nuclear export of encapsidated genomic RNAs
CC       (ribonucleoproteins, RNPs) (PubMed:23850870, PubMed:28202040).
CC       Interaction of viral NEP with M1-Hsc70 is thought to promote nuclear
CC       export of the viral encapsidated genomes (PubMed:28202040).
CC       {ECO:0000303|PubMed:23850870, ECO:0000303|PubMed:28202040}.
CC   -!- SUBUNIT: Interacts with host HSC70. {ECO:0000269|PubMed:28202040}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:28202040}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Nuclear export protein {ECO:0000269|PubMed:23850870};
CC         IsoId=Q8V3U1-1; Sequence=Displayed;
CC       Name=Non-structural protein 1;
CC         IsoId=Q8V3U2-1; Sequence=External;
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DR   EMBL; AF404341; AAL67957.1; -; Genomic_RNA.
DR   RefSeq; YP_145799.1; NC_006498.1.
DR   GeneID; 5075849; -.
DR   KEGG; vg:5075849; -.
DR   Proteomes; UP000008772; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Host cytoplasm; Host-virus interaction;
KW   Reference proteome.
FT   CHAIN           1..146
FT                   /note="Nuclear export protein"
FT                   /id="PRO_0000403923"
SQ   SEQUENCE   146 AA;  16268 MW;  A4616D7BBB30C89F CRC64;
     MNLLLLLQVA SFLSDSKVPG EDGTSSTSGM LDLLRDQVDS LSINDSTTEP KTRLDPGLYP
     WLKWTETAYR SSTRSLASTI VMGALVQQRG SGNGITMREL ELSLGLDFTS ECDWLKTCYV
     NKNFVFLSEK EIAVNMEVEK FICNEN