ID   NER_HAEIN               Reviewed;          89 AA.
AC   P46496;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Mu-like prophage FluMu DNA-binding protein Ner;
GN   Name=nlp; OrderedLocusNames=HI_1477;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Negative regulator of transcription starting from the Pe and
CC       Pc promoters of Mu. Also negatively regulates its own gene
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ner transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC23124.1; -; Genomic_DNA.
DR   RefSeq; NP_439628.1; NC_000907.1.
DR   RefSeq; WP_005693493.1; NC_000907.1.
DR   AlphaFoldDB; P46496; -.
DR   SMR; P46496; -.
DR   STRING; 71421.HI_1477; -.
DR   PRIDE; P46496; -.
DR   EnsemblBacteria; AAC23124; AAC23124; HI_1477.
DR   KEGG; hin:HI_1477; -.
DR   PATRIC; fig|71421.8.peg.1545; -.
DR   eggNOG; COG3423; Bacteria.
DR   HOGENOM; CLU_162005_3_0_6; -.
DR   OMA; VSPAEIW; -.
DR   PhylomeDB; P46496; -.
DR   BioCyc; HINF71421:G1GJ1-1502-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR038722; Ner_HTH_dom.
DR   Pfam; PF13693; HTH_35; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..89
FT                   /note="Mu-like prophage FluMu DNA-binding protein Ner"
FT                   /id="PRO_0000062785"
FT   DNA_BIND        57..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   89 AA;  10262 MW;  D6A755071E861FB1 CRC64;
     MSVLEKPKKT AEQDWHRADI LAELKKNGWS LRSLAKEGQV SYNTLKTVLD KSYPKMERLV
     ANAIGVPPEV IWAGRFAERN KRPTLQHKY