NET2B_ARATH
ID NET2B_ARATH Reviewed; 928 AA.
AC F4I131; O04494;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Protein NETWORKED 2B {ECO:0000303|PubMed:22840520};
GN Name=NET2B {ECO:0000303|PubMed:22840520};
GN OrderedLocusNames=At1g09720 {ECO:0000312|Araport:AT1G09720};
GN ORFNames=F21M12.11 {ECO:0000312|EMBL:AAB60728.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22840520; DOI=10.1016/j.cub.2012.06.041;
RA Deeks M.J., Calcutt J.R., Ingle E.K., Hawkins T.J., Chapman S.,
RA Richardson A.C., Mentlak D.A., Dixon M.R., Cartwright F., Smertenko A.P.,
RA Oparka K., Hussey P.J.;
RT "A superfamily of actin-binding proteins at the actin-membrane nexus of
RT higher plants.";
RL Curr. Biol. 22:1595-1600(2012).
RN [4]
RP GENE FAMILY.
RX PubMed=24926301; DOI=10.3389/fpls.2014.00254;
RA Hawkins T.J., Deeks M.J., Wang P., Hussey P.J.;
RT "The evolution of the actin binding NET superfamily.";
RL Front. Plant Sci. 5:254-254(2014).
CC -!- FUNCTION: Plant-specific actin binding protein. May be part of a
CC membrane-cytoskeletal adapter complex. {ECO:0000305|PubMed:22840520}.
CC -!- SIMILARITY: Belongs to the NET family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60728.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC000132; AAB60728.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28484.1; -; Genomic_DNA.
DR PIR; B86231; B86231.
DR RefSeq; NP_172443.2; NM_100844.2.
DR AlphaFoldDB; F4I131; -.
DR SMR; F4I131; -.
DR STRING; 3702.AT1G09720.1; -.
DR iPTMnet; F4I131; -.
DR PaxDb; F4I131; -.
DR PRIDE; F4I131; -.
DR EnsemblPlants; AT1G09720.1; AT1G09720.1; AT1G09720.
DR GeneID; 837500; -.
DR Gramene; AT1G09720.1; AT1G09720.1; AT1G09720.
DR KEGG; ath:AT1G09720; -.
DR Araport; AT1G09720; -.
DR TAIR; locus:2024271; AT1G09720.
DR eggNOG; ENOG502QQVH; Eukaryota.
DR HOGENOM; CLU_004324_0_0_1; -.
DR InParanoid; F4I131; -.
DR OMA; FQRVEDQ; -.
DR OrthoDB; 186795at2759; -.
DR PRO; PR:F4I131; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I131; baseline and differential.
DR Genevisible; F4I131; AT.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR InterPro; IPR011684; NAB.
DR Pfam; PF07765; KIP1; 1.
DR PROSITE; PS51774; NAB; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..928
FT /note="Protein NETWORKED 2B"
FT /id="PRO_0000431854"
FT DOMAIN 10..90
FT /note="NAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01110"
FT REGION 108..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 207..309
FT /evidence="ECO:0000255"
FT COILED 360..445
FT /evidence="ECO:0000255"
FT COILED 547..574
FT /evidence="ECO:0000255"
FT COMPBIAS 450..468
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 106069 MW; 0BDD7B037FAF4904 CRC64;
MLQRAASNAY SWWWASHIRT KQSKWLEHNL QDMEEKVKYT LKIIDGDGDS FAKRAEMYYR
KRPEIVNFVE EAFRSYRALA ERYDHLSTEL QSANHMIATA FPEHVPFPLV DDDDDDDDDN
PKKPPKHLHL IPSGTNIPQV PEVPKKEFKS QSLMVLSRKE PGVLQSSETS SALVSSGLSR
EEALEEIDKI HKGILVLQTE KEFVRSSYEQ SYDRYWNLEN EVEEMQKRVC SLQDEFGVGG
EIEDGEARTL VATAALSSCK ETIAKLEETQ KRFSEDAGIE KERIDTATER CEALKKKFEI
KVEEQAKKAF HGQESSYESV KESRQIDLNE NLSNVDFAEK IDELVEKVVS LETTALSHTA
LLKTLRSETN ELQDHIRDVE KDKACLVSDS MDMKKRITVL EDELRKVKNL FQRVEDQNKN
LHKHLTEANS TAKDLSGKLQ EVKMDEDVEG DGLNPEDIQE EDTVEDSDSI SNEREIKNAE
EIKEAMVIKQ SRDQESMQEE KSETRDSCGG LSETESTCFG TEAEDEERRN WRQLLPADGM
EDREKVLLDE YSSVLRDYRE VKRKLSEVEK KNRDGFFELA LQLRELKNAV SCEDVDFHFL
HQKPELPGQG FPHPVERNRA ESVSISHSSN SSFSMPPLPQ RGDLKRASEQ EKEDGFKVKF
AGISDSLRKK IPTVEEKVRG DIDAVLEENI EFWLRFSTSV HQIQKYHTSV QDLKAELSKI
ESKQQGNAGS SSNTALASEA KPIYRHLREI RTELQLWLEN SAILRDELEG RYATLCNIKD
EVSRVTSQSG ATEVSNTEIR GYQAAKFHGE ILNMKQENKR VFNELQAGLD RARALRAEVE
RVVCKLEENL GILDGTATRS LSKRMPSSAG KPRIPLRSFL FGVKLKKYKQ QPKQTSTIFS
CVSPSPALNK QCSYIIPPAK LPEYVKRS
