NET2C_ARATH
ID NET2C_ARATH Reviewed; 848 AA.
AC Q8LPQ1; Q9LXA2;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein NETWORKED 2C {ECO:0000303|PubMed:22840520};
GN Name=NET2C {ECO:0000303|PubMed:22840520};
GN OrderedLocusNames=At5g10500 {ECO:0000312|Araport:AT5G10500};
GN ORFNames=F12B17.150 {ECO:0000312|EMBL:CAB89393.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM19845.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22840520; DOI=10.1016/j.cub.2012.06.041;
RA Deeks M.J., Calcutt J.R., Ingle E.K., Hawkins T.J., Chapman S.,
RA Richardson A.C., Mentlak D.A., Dixon M.R., Cartwright F., Smertenko A.P.,
RA Oparka K., Hussey P.J.;
RT "A superfamily of actin-binding proteins at the actin-membrane nexus of
RT higher plants.";
RL Curr. Biol. 22:1595-1600(2012).
RN [5]
RP GENE FAMILY.
RX PubMed=24926301; DOI=10.3389/fpls.2014.00254;
RA Hawkins T.J., Deeks M.J., Wang P., Hussey P.J.;
RT "The evolution of the actin binding NET superfamily.";
RL Front. Plant Sci. 5:254-254(2014).
CC -!- FUNCTION: Plant-specific actin binding protein. May be part of a
CC membrane-cytoskeletal adapter complex. {ECO:0000305|PubMed:22840520}.
CC -!- SIMILARITY: Belongs to the NET family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB89393.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL353995; CAB89393.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91554.1; -; Genomic_DNA.
DR EMBL; AY094478; AAM19845.1; -; mRNA.
DR EMBL; BT002295; AAN72306.1; -; mRNA.
DR PIR; T49989; T49989.
DR RefSeq; NP_196612.2; NM_121088.4.
DR AlphaFoldDB; Q8LPQ1; -.
DR SMR; Q8LPQ1; -.
DR IntAct; Q8LPQ1; 2.
DR STRING; 3702.AT5G10500.1; -.
DR PaxDb; Q8LPQ1; -.
DR PRIDE; Q8LPQ1; -.
DR ProteomicsDB; 249044; -.
DR EnsemblPlants; AT5G10500.1; AT5G10500.1; AT5G10500.
DR GeneID; 830914; -.
DR Gramene; AT5G10500.1; AT5G10500.1; AT5G10500.
DR KEGG; ath:AT5G10500; -.
DR Araport; AT5G10500; -.
DR TAIR; locus:2142554; AT5G10500.
DR eggNOG; ENOG502QQVH; Eukaryota.
DR HOGENOM; CLU_004324_0_0_1; -.
DR InParanoid; Q8LPQ1; -.
DR OMA; QVCHFQD; -.
DR OrthoDB; 186795at2759; -.
DR PhylomeDB; Q8LPQ1; -.
DR PRO; PR:Q8LPQ1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LPQ1; baseline and differential.
DR Genevisible; Q8LPQ1; AT.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR InterPro; IPR011684; NAB.
DR Pfam; PF07765; KIP1; 1.
DR PROSITE; PS51774; NAB; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..848
FT /note="Protein NETWORKED 2C"
FT /id="PRO_0000431855"
FT DOMAIN 10..90
FT /note="NAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01110"
FT REGION 108..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 172..204
FT /evidence="ECO:0000255"
FT COILED 241..278
FT /evidence="ECO:0000255"
FT COILED 305..454
FT /evidence="ECO:0000255"
FT COILED 752..797
FT /evidence="ECO:0000255"
SQ SEQUENCE 848 AA; 96883 MW; 347C5623445F1EDE CRC64;
MLRRAASNAY SWWWASHVRT KQSKWLEENL QDIEEKVEYA LKLLEDEGDS FAKRAEMYYK
RRPELISFVE ESFKAYRALA ERYDHISKEL QNANTTIASV FPDQVPEFAM NEDDDDDAPV
SPRHHKNKTS NKNVPKVPDL PIKDPEAAKK MFMSRKAIQE QNASSVVNKS GLSKTEAVEE
IDKLQKEILV LQTEKEFVKT SYENGLAKYW EIEKCIMEKQ GKVSSLQDEF DEGAVVIEDK
EAQILMSTTA LKSCQEKLEE LRDKQEQNVK EVDVSRKQIS ESTEEFGNLS DALLGDGKGN
HEIYSEKEKL ESLGEKVNDE FDDSEAKSCL TIPDVADKID ELVNDVINLE NLFSSQAALI
HRLREEIDDL KAQIRALQKE NNSSQTDDNM DMGKKLKEME EKVNGVKDID QEVEEKSDNI
DKHLTRAHMK LSFLSKRLKS LTQEGEDEEL KATNVPIQDI GSLTDTKFPE ENIDDTVVSE
NALDIKSASE VVFAEKDLSD EVNQEEAIET KTKEASLSDL EKHISSPKSD IITTQESSDE
LFLQKLLAHG IEGREKHLLT EYTKVLRNYK EVKKLLHETE TKLKNVNTLK DEGKDQQRGQ
LFMLICREDN NATNAITGQK QRMSPNEEQL GARVDALLSE NLNLLVRFSN SFGKIQQFDT
GIKDLHGEML KIIKQKNQDG GKNTLRSNVR PIYKHLSEIR TEMTVWLEKS LLLKEEINIR
ASTLSDIHNE ITEALKTDSE DSEIKFTIYQ GAKFEGEVSN MKKENNRIAE ELQTGLDQVT
KLMKDADTTL EKLSEEFSLS ESNTQSSQDR SRIPLRSFIF DRKPKKQRLS LFSCIQPSLS
KMKKPAGS
