NET2D_ARATH
ID NET2D_ARATH Reviewed; 947 AA.
AC F4IJK1; Q9SJX9;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Protein NETWORKED 2D {ECO:0000303|PubMed:22840520};
GN Name=NET2D {ECO:0000303|PubMed:22840520};
GN OrderedLocusNames=At2g22560 {ECO:0000312|Araport:AT2G22560};
GN ORFNames=F14M13.4 {ECO:0000312|EMBL:AAD22346.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22840520; DOI=10.1016/j.cub.2012.06.041;
RA Deeks M.J., Calcutt J.R., Ingle E.K., Hawkins T.J., Chapman S.,
RA Richardson A.C., Mentlak D.A., Dixon M.R., Cartwright F., Smertenko A.P.,
RA Oparka K., Hussey P.J.;
RT "A superfamily of actin-binding proteins at the actin-membrane nexus of
RT higher plants.";
RL Curr. Biol. 22:1595-1600(2012).
RN [4]
RP GENE FAMILY.
RX PubMed=24926301; DOI=10.3389/fpls.2014.00254;
RA Hawkins T.J., Deeks M.J., Wang P., Hussey P.J.;
RT "The evolution of the actin binding NET superfamily.";
RL Front. Plant Sci. 5:254-254(2014).
CC -!- FUNCTION: Plant-specific actin binding protein. May be part of a
CC membrane-cytoskeletal adapter complex. {ECO:0000305|PubMed:22840520}.
CC -!- SIMILARITY: Belongs to the NET family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD22346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006592; AAD22346.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07322.1; -; Genomic_DNA.
DR PIR; B84614; B84614.
DR RefSeq; NP_179842.2; NM_127822.3.
DR AlphaFoldDB; F4IJK1; -.
DR SMR; F4IJK1; -.
DR STRING; 3702.AT2G22560.1; -.
DR iPTMnet; F4IJK1; -.
DR PaxDb; F4IJK1; -.
DR PRIDE; F4IJK1; -.
DR ProteomicsDB; 251294; -.
DR EnsemblPlants; AT2G22560.1; AT2G22560.1; AT2G22560.
DR GeneID; 816788; -.
DR Gramene; AT2G22560.1; AT2G22560.1; AT2G22560.
DR KEGG; ath:AT2G22560; -.
DR Araport; AT2G22560; -.
DR TAIR; locus:2041203; AT2G22560.
DR eggNOG; ENOG502QQVH; Eukaryota.
DR HOGENOM; CLU_004324_0_0_1; -.
DR InParanoid; F4IJK1; -.
DR OMA; THFTEAR; -.
DR OrthoDB; 186795at2759; -.
DR PRO; PR:F4IJK1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IJK1; baseline and differential.
DR Genevisible; F4IJK1; AT.
DR GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR InterPro; IPR011684; NAB.
DR Pfam; PF07765; KIP1; 1.
DR PROSITE; PS51774; NAB; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..947
FT /note="Protein NETWORKED 2D"
FT /id="PRO_0000431856"
FT DOMAIN 10..90
FT /note="NAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01110"
FT REGION 455..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..205
FT /evidence="ECO:0000255"
FT COILED 247..342
FT /evidence="ECO:0000255"
FT COILED 375..433
FT /evidence="ECO:0000255"
FT COILED 645..684
FT /evidence="ECO:0000255"
FT COILED 744..773
FT /evidence="ECO:0000255"
FT COMPBIAS 475..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 108171 MW; 96107DD3931FEFAC CRC64;
MLQRAASNAY SWWWASHIRT KQSKWLEQNL QDIEEKVQYV LKLLQEDGDS FAKRAEMYYK
KRPELISFVE ESYRAYRALA ERYDHISTEL QNANTTIASV FPDQVPNFAM DDDIDMSKFA
KRSNISGANV PNVPKLPVKD LKSAVRVATK KLQPRKSMKY TGGSTNVVVK SSGLSKPEAM
GEIDKLQKEI LALQTEKEFV KSSYEIGLSK YWEFEKGIKE KQERICGLQD EFGESVAIED
EEARRLMTET AIKSCQEKLV ELQEKQEKSY EEAREEHVKI KESKEKLRSM ASQFLGDESV
FAKDDGDEVR RTAELDHEIK EMSRKKKELE SVKEKIREHF ESGANSSLNG TDMAEKVDEL
VNKVISLESA VSSQTALIQR LRNETNGLQT QISTLETDKA LLADDKSDLR NKLKEMEEKL
KALQDLDRNV LDKSSNLQTH FDDACHNLDN LSGGNLHEVK PESESDNLAI SIEPQKDLEG
EKRTLDISEE IKEHQKETGE EKKEAPVKSV KFEQTRNATI AEDSTIPSTN PDTVLESTEK
VDSDLEKQDA SDKTDSVLDN VLENQAASDQ TDSVLDSVLE KQGESDKIDS VPSNVSEKES
DISFNGEQQE DQKEKEGEPD WKEMFMKGME NREKHLLTEY TTILRNFKDM KKTLDETKTK
MKTENATKDD EIKLLREKMS LLQKGLGDSN DLMENQLSND DYSIGFMAAE NQNMSLVEEQ
FRLNIDELLE ENLDFWLRFS TAFGQIQSYD TSIEDLQAEI SKLEQRRKQD GSSTAKYALR
SDVRPLYVHL REINTDLGLW LEKGAALKEE LKSRFESLCN IQDEITKALK SSAEDDDFRF
TSYQAAKFQG EVLNMKQENN KVADELQAGL DHITTLQLEV DKTLGKLIDE FALSGSKNKS
DLDLQHSDSR SRVPLRSFIF GSKQKRAKPS IFSCMHPSLY RKMKTST
