NET3A_ARATH
ID NET3A_ARATH Reviewed; 269 AA.
AC Q66GR8; Q67ZU6; Q9LR76;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein NETWORKED 3A {ECO:0000303|PubMed:22840520};
GN Name=NET3A {ECO:0000303|PubMed:22840520};
GN OrderedLocusNames=At1g03470 {ECO:0000312|Araport:AT1G03470};
GN ORFNames=F21B7.9 {ECO:0000312|EMBL:AAF86537.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAU05457.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-269.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION, DOMAIN, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22840520; DOI=10.1016/j.cub.2012.06.041;
RA Deeks M.J., Calcutt J.R., Ingle E.K., Hawkins T.J., Chapman S.,
RA Richardson A.C., Mentlak D.A., Dixon M.R., Cartwright F., Smertenko A.P.,
RA Oparka K., Hussey P.J.;
RT "A superfamily of actin-binding proteins at the actin-membrane nexus of
RT higher plants.";
RL Curr. Biol. 22:1595-1600(2012).
RN [6]
RP GENE FAMILY.
RX PubMed=24926301; DOI=10.3389/fpls.2014.00254;
RA Hawkins T.J., Deeks M.J., Wang P., Hussey P.J.;
RT "The evolution of the actin binding NET superfamily.";
RL Front. Plant Sci. 5:254-254(2014).
CC -!- FUNCTION: Plant-specific actin binding protein. May be part of a
CC membrane-cytoskeletal adapter complex. {ECO:0000305|PubMed:22840520}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:22840520}. Nucleus membrane
CC {ECO:0000269|PubMed:22840520}.
CC -!- DOMAIN: The NAB domain, also called NAB (NET actin-binding) domain, is
CC sufficient for F-actin binding. {ECO:0000269|PubMed:22840520}.
CC -!- SIMILARITY: Belongs to the NET family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF86537.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002560; AAF86537.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE27575.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27576.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60841.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60842.1; -; Genomic_DNA.
DR EMBL; BT015334; AAU05457.1; -; mRNA.
DR EMBL; BT015710; AAU45208.1; -; mRNA.
DR EMBL; AK176021; BAD43784.1; -; mRNA.
DR PIR; T00911; T00911.
DR RefSeq; NP_001030943.1; NM_001035866.2.
DR RefSeq; NP_001318913.1; NM_001331414.1.
DR RefSeq; NP_001323097.1; NM_001331415.1.
DR RefSeq; NP_171846.2; NM_100229.4.
DR AlphaFoldDB; Q66GR8; -.
DR SMR; Q66GR8; -.
DR STRING; 3702.AT1G03470.1; -.
DR PaxDb; Q66GR8; -.
DR PRIDE; Q66GR8; -.
DR ProteomicsDB; 251189; -.
DR EnsemblPlants; AT1G03470.1; AT1G03470.1; AT1G03470.
DR EnsemblPlants; AT1G03470.2; AT1G03470.2; AT1G03470.
DR EnsemblPlants; AT1G03470.3; AT1G03470.3; AT1G03470.
DR EnsemblPlants; AT1G03470.4; AT1G03470.4; AT1G03470.
DR GeneID; 839494; -.
DR Gramene; AT1G03470.1; AT1G03470.1; AT1G03470.
DR Gramene; AT1G03470.2; AT1G03470.2; AT1G03470.
DR Gramene; AT1G03470.3; AT1G03470.3; AT1G03470.
DR Gramene; AT1G03470.4; AT1G03470.4; AT1G03470.
DR KEGG; ath:AT1G03470; -.
DR Araport; AT1G03470; -.
DR TAIR; locus:2020843; AT1G03470.
DR eggNOG; ENOG502R3Z2; Eukaryota.
DR HOGENOM; CLU_072690_1_0_1; -.
DR InParanoid; Q66GR8; -.
DR OMA; EACETHE; -.
DR OrthoDB; 1214013at2759; -.
DR PhylomeDB; Q66GR8; -.
DR PRO; PR:Q66GR8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q66GR8; baseline and differential.
DR Genevisible; Q66GR8; AT.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IDA:TAIR.
DR GO; GO:0005774; C:vacuolar membrane; IDA:TAIR.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR InterPro; IPR011684; NAB.
DR Pfam; PF07765; KIP1; 1.
DR PROSITE; PS51774; NAB; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW Reference proteome.
FT CHAIN 1..269
FT /note="Protein NETWORKED 3A"
FT /id="PRO_0000431857"
FT DOMAIN 6..87
FT /note="NAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01110"
FT REGION 87..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 155..214
FT /evidence="ECO:0000255"
SQ SEQUENCE 269 AA; 31481 MW; A9ED3C39B19F7EAF CRC64;
MVMDSSKWWW IGNHNTTNFS PWLHSTLSEL DEKTKEMLRV IDEDADSFAA RAEMYYKKRP
ELIAMVEEFY RSHRSLAERY DLLRPSSVHK HGSDSESHEK SSTCDESSWS EACETHEEYA
ESEIDNGESK WVDESEIDGI VEEIEPSEVV YSEGNGNSEM MKIEIERLRE ENKVYSEMVR
EKDEEKREAI RQMSVAIQML KEENSELKKR VTNTVVARRN KEGGDSQRKQ QMWKPFEFKK
IKLEGLWGKG FGNWALPNTD STSKELMTL
