NET5_HUMAN
ID NET5_HUMAN Reviewed; 489 AA.
AC Q8WTR8; Q8N4X9; Q8WU63;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Netrin-5;
DE AltName: Full=Netrin-1-like protein;
DE Flags: Precursor;
GN Name=NTN5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in neurogenesis. Prevents motor neuron cell body
CC migration out of the neural tube. {ECO:0000250|UniProtKB:Q3UQ22}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WTR8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WTR8-2; Sequence=VSP_031667, VSP_031668;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH471177; EAW52386.1; -; Genomic_DNA.
DR EMBL; CH471177; EAW52387.1; -; Genomic_DNA.
DR EMBL; BC018654; AAH18654.2; -; mRNA.
DR EMBL; BC018697; AAH18697.2; -; mRNA.
DR EMBL; BC021210; AAH21210.2; -; mRNA.
DR EMBL; BC033207; AAH33207.1; -; mRNA.
DR CCDS; CCDS33068.1; -. [Q8WTR8-1]
DR RefSeq; NP_665806.1; NM_145807.2. [Q8WTR8-1]
DR AlphaFoldDB; Q8WTR8; -.
DR SMR; Q8WTR8; -.
DR BioGRID; 125960; 23.
DR STRING; 9606.ENSP00000270235; -.
DR GlyGen; Q8WTR8; 1 site.
DR PhosphoSitePlus; Q8WTR8; -.
DR BioMuta; NTN5; -.
DR DMDM; 74730628; -.
DR MassIVE; Q8WTR8; -.
DR PaxDb; Q8WTR8; -.
DR PRIDE; Q8WTR8; -.
DR ProteomicsDB; 74592; -. [Q8WTR8-1]
DR ProteomicsDB; 74593; -. [Q8WTR8-2]
DR Antibodypedia; 31764; 52 antibodies from 14 providers.
DR DNASU; 126147; -.
DR Ensembl; ENST00000270235.11; ENSP00000270235.4; ENSG00000142233.14. [Q8WTR8-1]
DR GeneID; 126147; -.
DR KEGG; hsa:126147; -.
DR MANE-Select; ENST00000270235.11; ENSP00000270235.4; NM_145807.4; NP_665806.1.
DR UCSC; uc002pkb.3; human. [Q8WTR8-1]
DR CTD; 126147; -.
DR DisGeNET; 126147; -.
DR GeneCards; NTN5; -.
DR HGNC; HGNC:25208; NTN5.
DR HPA; ENSG00000142233; Tissue enhanced (pituitary).
DR neXtProt; NX_Q8WTR8; -.
DR OpenTargets; ENSG00000142233; -.
DR PharmGKB; PA164724232; -.
DR VEuPathDB; HostDB:ENSG00000142233; -.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00940000161874; -.
DR HOGENOM; CLU_018213_0_0_1; -.
DR InParanoid; Q8WTR8; -.
DR OMA; SCPQACA; -.
DR OrthoDB; 858946at2759; -.
DR PhylomeDB; Q8WTR8; -.
DR TreeFam; TF352481; -.
DR PathwayCommons; Q8WTR8; -.
DR SignaLink; Q8WTR8; -.
DR BioGRID-ORCS; 126147; 16 hits in 1067 CRISPR screens.
DR GenomeRNAi; 126147; -.
DR Pharos; Q8WTR8; Tdark.
DR PRO; PR:Q8WTR8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WTR8; protein.
DR Bgee; ENSG00000142233; Expressed in right uterine tube and 92 other tissues.
DR ExpressionAtlas; Q8WTR8; baseline and differential.
DR Genevisible; Q8WTR8; HS.
DR GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR GO; GO:0008045; P:motor neuron axon guidance; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SUPFAM; SSF50242; SSF50242; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 3.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Disulfide bond; Glycoprotein;
KW Laminin EGF-like domain; Neurogenesis; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..489
FT /note="Netrin-5"
FT /id="PRO_0000320575"
FT DOMAIN 157..211
FT /note="Laminin EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DOMAIN 212..274
FT /note="Laminin EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DOMAIN 275..324
FT /note="Laminin EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DOMAIN 345..475
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT REGION 470..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 157..166
FT /evidence="ECO:0000250"
FT DISULFID 159..175
FT /evidence="ECO:0000250"
FT DISULFID 177..186
FT /evidence="ECO:0000250"
FT DISULFID 189..209
FT /evidence="ECO:0000250"
FT DISULFID 212..221
FT /evidence="ECO:0000250"
FT DISULFID 214..239
FT /evidence="ECO:0000250"
FT DISULFID 242..251
FT /evidence="ECO:0000250"
FT DISULFID 254..272
FT /evidence="ECO:0000250"
FT DISULFID 275..287
FT /evidence="ECO:0000250"
FT DISULFID 277..294
FT /evidence="ECO:0000250"
FT DISULFID 296..305
FT /evidence="ECO:0000250"
FT DISULFID 308..322
FT /evidence="ECO:0000250"
FT DISULFID 345..418
FT /evidence="ECO:0000250"
FT DISULFID 349..420
FT /evidence="ECO:0000250"
FT DISULFID 364..475
FT /evidence="ECO:0000250"
FT VAR_SEQ 342..350
FT /note="DPQCQNYCN -> GKTVWHGGP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031667"
FT VAR_SEQ 351..489
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031668"
SQ SEQUENCE 489 AA; 53174 MW; 3438D41FA45F8B3E CRC64;
MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET
CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER
VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH
TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE
RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL
RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC
LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA
PTPSPRPEH
